C4B63_18g157

DNA ligase I

Trypanosoma cruzi Dm28c 2018 OG6: OG6_100906 OG7: OG7_0002598 194 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 194 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_339g3 ⚠ tRNA-dihydrouridine synthase 3	—	OG6 TCSYLVIO_003375 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_009102 OG7 LdBPK_303490.1 ↔ LdBPK_311970.1	Both
C4B63_322g8 ⚠ dihydrouridine synthase (Dus)	—	OG6 LdBPK_303490.1 ↔ LdBPK_311970.1 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_009102 OG7 LdBPK_303490.1 ↔ LdBPK_311970.1	Both
C4B63_294g17 ⚠ dihydrouridine synthase (Dus)	—	OG6 LdBPK_303490.1 ↔ LdBPK_311970.1 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_009102 OG7 LdBPK_303490.1 ↔ LdBPK_311970.1	Both
C4B63_350g11 ⚠ dihydrouridine synthase (Dus)	—	OG6 LdBPK_303490.1 ↔ LdBPK_311970.1 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_009102 OG7 LdBPK_303490.1 ↔ LdBPK_311970.1	Both
C4B63_313g3 ⚠ dihydrouridine synthase (Dus)(fragment)	—	OG6 LdBPK_303490.1 ↔ LdBPK_311970.1 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_009102 OG7 LdBPK_303490.1 ↔ LdBPK_311970.1	Both
C4B63_336g10 ⚠ dihydrouridine synthase (Dus)	—	OG6 LdBPK_303490.1 ↔ LdBPK_311970.1 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_009102 OG7 LdBPK_303490.1 ↔ LdBPK_311970.1	Both
C4B63_294g18 ⚠ dihydrouridine synthase (Dus)	—	OG6 LdBPK_303490.1 ↔ LdBPK_311970.1 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_009102 OG7 LdBPK_303490.1 ↔ LdBPK_311970.1	Both
C4B63_23g268 Tubulin-specific chaperone E	—	OG6 TCSYLVIO_003375 ↔ TCSYLVIO_004471 OG6 LdBPK_030750.1 ↔ LdBPK_303490.1 OG7 LdBPK_030750.1 ↔ LdBPK_303490.1 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_004471	Both
C4B63_13g118 ⚠ tRNA-dihydrouridine synthase 2	—	OG7 TCSYLVIO_003375 ↔ TCSYLVIO_009102 OG7 LdBPK_303490.1 ↔ LdBPK_311970.1	OG7
C4B63_20g51 ⚠ tRNA-dihydrouridine synthase 4	—	OG7 TCSYLVIO_003375 ↔ TCSYLVIO_009102 OG7 LdBPK_303490.1 ↔ LdBPK_311970.1	OG7
C4B63_61g23 ⚠ tRNA-dihydrouridine synthase 3	—	OG6 TCSYLVIO_003375 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_009102 OG7 LdBPK_303490.1 ↔ LdBPK_311970.1	Both
C4B63_49g81 ⚠ translation initiation factor IF-2	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_003375	Both
C4B63_1g121c ⚠ cytochrome b5-like protein	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_003375	OG7
C4B63_70g572c ⚠ cytochrome b5	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_003375	OG7
C4B63_34g372 ⚠ cytochrome b-domain protein	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_003375	OG7
C4B63_72g106 ⚠ DIS3-like exonuclease(fragment)	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003375	OG7
C4B63_276g11 ⚠ DIS3-like exonuclease(fragment)	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003375	OG7
C4B63_30g129 ⚠ rrp44p homologue	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003375	OG7
C4B63_16g162 conserved hypothetical protein	—	OG6 TCSYLVIO_000215 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_000215 ↔ TCSYLVIO_003375	Both
C4B63_70g77 ⚠ acidocalcisomal pyrophosphatase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003375	Both
C4B63_23g248 ⚠ inorganic pyrophosphatase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003375	Both
C4B63_56g85 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001973 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_001973 ↔ TCSYLVIO_003375	Both
C4B63_56g84 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001973 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_001973 ↔ TCSYLVIO_003375	Both
C4B63_34g118 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_000836 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_003375	Both
C4B63_109g37 ⚠ Gar1/Naf1 RNA binding region containing prote	—	OG6 TCSYLVIO_000836 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_003375	Both
C4B63_49g130 ⚠ Putative hydrolase C777.06c	—	OG6 LdBPK_220940.1 ↔ LdBPK_303490.1 OG7 LdBPK_220940.1 ↔ LdBPK_303490.1	Both
C4B63_49g131 ⚠ conserved hypothetical protein	—	OG6 LdBPK_220940.1 ↔ LdBPK_303490.1 OG7 LdBPK_220940.1 ↔ LdBPK_303490.1	Both
C4B63_102g71 ⚠ Programmed cell death protein 2, C-terminal d	—	OG6 LdBPK_211190.1 ↔ LdBPK_303490.1 OG7 LdBPK_211190.1 ↔ LdBPK_303490.1	Both
C4B63_16g122 ⚠ Beta-lactamase superfamily domain containing	—	OG6 LdBPK_220940.1 ↔ LdBPK_303490.1 OG7 LdBPK_220940.1 ↔ LdBPK_303490.1	Both
C4B63_6g411 Replication factor A 51 kDa subunit	—	OG6 LdBPK_281940.1 ↔ LdBPK_303490.1 OG7 LdBPK_281940.1 ↔ LdBPK_303490.1	Both
C4B63_168g23 ⚠ Programmed cell death protein 2, C-terminal d	—	OG6 LdBPK_211190.1 ↔ LdBPK_303490.1 OG7 LdBPK_211190.1 ↔ LdBPK_303490.1	Both
C4B63_6g521 ⚠ DIS3-like exonuclease	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_003375 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003375	Both
C4B63_49g166 ⚠ alanyl-tRNA synthetase	—	OG6 TCSYLVIO_001889 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_001889 ↔ TCSYLVIO_003375	Both
C4B63_20g29 conserved hypothetical protein	—	OG6 TCSYLVIO_003375 ↔ TCSYLVIO_003923 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_003923	Both
C4B63_175g8 ⚠ TPR-repeat protein	—	OG6 TCSYLVIO_003375 ↔ TCSYLVIO_003496	OG6
C4B63_120g70 ⚠ Peptide chain release factor 1, mitochondrial	—	OG6 TCSYLVIO_003375 ↔ TCSYLVIO_006272 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_006272	Both
C4B63_246g3 ⚠ Tetratricopeptide repeat protein 4	—	OG6 TCSYLVIO_003375 ↔ TCSYLVIO_004874 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_004874	Both
C4B63_4g375 ⚠ glucan 1,3-alpha-glucosidase	—	OG6 TCSYLVIO_003375 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_003375 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_006141	Both
C4B63_10g517 ⚠ tryptophanyl-tRNA synthetase	—	OG6 TCSYLVIO_003375 ↔ TCSYLVIO_010724	OG6
C4B63_4g214 ⚠ cyclophilin type peptidyl-prolyl cis-trans is	—	OG6 TCSYLVIO_003375 ↔ TCSYLVIO_006217	OG6
C4B63_4g213 ⚠ cyclophilin type peptidyl-prolyl cis-trans is	—	OG6 TCSYLVIO_003375 ↔ TCSYLVIO_006217	OG6
C4B63_54g22 conserved hypothetical protein	—	OG6 TCSYLVIO_003375 ↔ TCSYLVIO_005080 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_005080	Both
C4B63_25g221 UDP-sugar pyrophosphorylase	—	OG6 TCSYLVIO_003375 ↔ TCSYLVIO_008914 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_008914	Both
C4B63_23g109 ⚠ UDP-glucose:glycoprotein glucosyltransferase	—	OG6 TCSYLVIO_003375 ↔ TCSYLVIO_004363 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_004363	Both
C4B63_18g214 S-adenosylmethionine decarboxylase proenzyme	—	OG6 TCSYLVIO_003342 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_003342 ↔ TCSYLVIO_003375	Both
C4B63_21g114 ⚠ oxidoreductase	—	OG7 LdBPK_100610.1 ↔ LdBPK_303490.1	OG7
C4B63_6g444 phosphonopyruvate decarboxylase	—	OG6 TCSYLVIO_002596 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_002596 ↔ TCSYLVIO_003375	Both
C4B63_18g286 conserved hypothetical protein	—	OG6 TCSYLVIO_003285 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_003285 ↔ TCSYLVIO_003375	Both
C4B63_34g313 casein kinase II, alpha chain	—	OG6 LdBPK_020330.1 ↔ LdBPK_303490.1	OG6
C4B63_49g164 ⚠ alanyl-tRNA synthetase	—	OG6 TCSYLVIO_001889 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_001889 ↔ TCSYLVIO_003375	Both

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