C4B63_18g157

DNA ligase I
Trypanosoma cruzi Dm28c 2018 OG6: OG6_100906 OG7: OG7_0002598 194 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 194 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_339g3 ⚠
tRNA-dihydrouridine synthase 3
— Both
C4B63_322g8 ⚠
dihydrouridine synthase (Dus)
— Both
C4B63_294g17 ⚠
dihydrouridine synthase (Dus)
— Both
C4B63_350g11 ⚠
dihydrouridine synthase (Dus)
— Both
C4B63_313g3 ⚠
dihydrouridine synthase (Dus)(fragment)
— Both
C4B63_336g10 ⚠
dihydrouridine synthase (Dus)
— Both
C4B63_294g18 ⚠
dihydrouridine synthase (Dus)
— Both
C4B63_23g268
Tubulin-specific chaperone E
— Both
C4B63_13g118 ⚠
tRNA-dihydrouridine synthase 2
— OG7
C4B63_20g51 ⚠
tRNA-dihydrouridine synthase 4
— OG7
C4B63_61g23 ⚠
tRNA-dihydrouridine synthase 3
— Both
C4B63_49g81 ⚠
translation initiation factor IF-2
— Both
C4B63_1g121c ⚠
cytochrome b5-like protein
— OG7
C4B63_70g572c ⚠
cytochrome b5
— OG7
C4B63_34g372 ⚠
cytochrome b-domain protein
— OG7
C4B63_72g106 ⚠
DIS3-like exonuclease(fragment)
— OG7
C4B63_276g11 ⚠
DIS3-like exonuclease(fragment)
— OG7
C4B63_30g129 ⚠
rrp44p homologue
— OG7
C4B63_16g162
conserved hypothetical protein
— Both
C4B63_70g77 ⚠
acidocalcisomal pyrophosphatase
— Both
C4B63_23g248 ⚠
inorganic pyrophosphatase
— Both
C4B63_56g85 ⚠
conserved hypothetical protein
— Both
C4B63_56g84 ⚠
conserved hypothetical protein
— Both
C4B63_34g118 ⚠
conserved hypothetical protein
— Both
C4B63_109g37 ⚠
Gar1/Naf1 RNA binding region containing prote
— Both
C4B63_49g130 ⚠
Putative hydrolase C777.06c
— Both
C4B63_49g131 ⚠
conserved hypothetical protein
— Both
C4B63_102g71 ⚠
Programmed cell death protein 2, C-terminal d
— Both
C4B63_16g122 ⚠
Beta-lactamase superfamily domain containing
— Both
C4B63_6g411
Replication factor A 51 kDa subunit
— Both
C4B63_168g23 ⚠
Programmed cell death protein 2, C-terminal d
— Both
C4B63_6g521 ⚠
DIS3-like exonuclease
— Both
C4B63_49g166 ⚠
alanyl-tRNA synthetase
— Both
C4B63_20g29
conserved hypothetical protein
— Both
C4B63_175g8 ⚠
TPR-repeat protein
— OG6
C4B63_120g70 ⚠
Peptide chain release factor 1, mitochondrial
— Both
C4B63_246g3 ⚠
Tetratricopeptide repeat protein 4
— Both
C4B63_4g375 ⚠
glucan 1,3-alpha-glucosidase
— Both
C4B63_10g517 ⚠
tryptophanyl-tRNA synthetase
— OG6
C4B63_4g214 ⚠
cyclophilin type peptidyl-prolyl cis-trans is
— OG6
C4B63_4g213 ⚠
cyclophilin type peptidyl-prolyl cis-trans is
— OG6
C4B63_54g22
conserved hypothetical protein
— Both
C4B63_25g221
UDP-sugar pyrophosphorylase
— Both
C4B63_23g109 ⚠
UDP-glucose:glycoprotein glucosyltransferase
— Both
C4B63_18g214
S-adenosylmethionine decarboxylase proenzyme
— Both
C4B63_21g114 ⚠
oxidoreductase
— OG7
C4B63_6g444
phosphonopyruvate decarboxylase
— Both
C4B63_18g286
conserved hypothetical protein
— Both
C4B63_34g313
casein kinase II, alpha chain
— OG6
C4B63_49g164 ⚠
alanyl-tRNA synthetase
— Both
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.