LAMA_000448800

TCP-1/cpn60 chaperonin family, putative

Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_100235 OG7: OG7_0001068 90 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 90 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LAMA_000377000 ⚠ TCP-1/cpn60 chaperonin family, putative	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_004584 OG6 TCSYLVIO_004200 ↔ TCSYLVIO_004584 OG6 LdBPK_321060.1 ↔ LdBPK_367240.1 OG6 Tb927.10.8190 ↔ Tb927.8.3150 +86 more	Both
LAMA_000805000 ⚠ TCP-1/cpn60 chaperonin family, putative	—	OG6 Tb927.11.14250 ↔ Tb927.9.11270 OG6 Tb927.8.3150 ↔ Tb927.9.11270 OG6 TCSYLVIO_000177 ↔ TCSYLVIO_005772 OG6 TCSYLVIO_004200 ↔ TCSYLVIO_005772 +86 more	Both
LAMA_000209500 ⚠ TCP-1/cpn60 chaperonin family, putative	—	OG6 Tb927.11.14250 ↔ Tb927.11.3240 OG6 TCSYLVIO_000177 ↔ TCSYLVIO_003488 OG6 TCSYLVIO_003488 ↔ TCSYLVIO_004200 OG6 LdBPK_131400.1 ↔ LdBPK_231460.1 +86 more	Both
LAMA_000664300 ⚠ TCP-1/cpn60 chaperonin family, putative	—	OG6 Tb927.11.14250 ↔ Tb927.8.3150 OG6 TCSYLVIO_000177 ↔ TCSYLVIO_004200 OG6 LdBPK_231460.1 ↔ LdBPK_321060.1 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_005312 +83 more	Both
LAMA_000688200 ⚠ TCP-1/cpn60 chaperonin family, putative	—	OG6 Tb927.11.14250 ↔ Tb927.11.16760 OG6 TCSYLVIO_000177 ↔ TCSYLVIO_005312 OG6 TCSYLVIO_004200 ↔ TCSYLVIO_005312 OG6 Tb927.11.16760 ↔ Tb927.8.3150 +86 more	Both
LAMA_000541800 ⚠ TCP-1/cpn60 chaperonin family, putative	—	OG6 Tb927.11.14250 ↔ Tb927.11.1900 OG6 Tb927.11.1900 ↔ Tb927.8.3150 OG6 LdBPK_271150.1 ↔ LdBPK_321060.1 OG6 TCSYLVIO_000177 ↔ TCSYLVIO_005500 +86 more	Both
LAMA_000408000 ⚠ TCP-1/cpn60 chaperonin family, putative	—	OG6 Tb927.10.1060 ↔ Tb927.8.3150 OG6 Tb927.10.1060 ↔ Tb927.11.14250 OG6 LdBPK_211330.1 ↔ LdBPK_231460.1 OG6 LdBPK_211330.1 ↔ LdBPK_321060.1 +86 more	Both
LAMA_000416900 ⚠ Proteasome subunit A N-terminal signature/Pro	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_009373 OG6 TCSYLVIO_004200 ↔ TCSYLVIO_009373 OG7 Tb927.10.6030 ↔ Tb927.11.1900 OG7 Tb927.10.230 ↔ Tb927.11.3240 +42 more	Both
LAMA_000530500 ⚠ Proteasome subunit A N-terminal signature/Pro	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_003527 OG6 TCSYLVIO_003527 ↔ TCSYLVIO_004200 OG7 Tb927.10.6030 ↔ Tb927.11.1900 OG7 Tb927.10.230 ↔ Tb927.11.3240 +42 more	Both
LAMA_000322400 ⚠ Proteasome subunit A N-terminal signature/Pro	—	OG7 Tb927.10.6030 ↔ Tb927.11.1900 OG7 Tb927.10.230 ↔ Tb927.11.3240 OG7 Tb927.10.6030 ↔ Tb927.11.16760 OG7 Tb927.7.4420 ↔ Tb927.8.3150 +40 more	OG7
LAMA_000416000 ⚠ Proteasome subunit A N-terminal signature/Pro	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_009369 OG6 TCSYLVIO_004200 ↔ TCSYLVIO_009369 OG7 Tb927.10.6030 ↔ Tb927.11.1900 OG7 Tb927.10.230 ↔ Tb927.11.3240 +42 more	Both
LAMA_000684900 ⚠ Phosducin/Thioredoxin, putative	—	OG6 TCSYLVIO_000453 ↔ TCSYLVIO_004200 OG6 TCSYLVIO_000177 ↔ TCSYLVIO_000453 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_000453 OG7 Tb927.11.1900 ↔ Tb927.2.4850 +7 more	Both
LAMA_000551000 ⚠ Phosducin/Thioredoxin, putative	—	OG6 TCSYLVIO_000453 ↔ TCSYLVIO_004200 OG6 TCSYLVIO_000177 ↔ TCSYLVIO_000453 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_000453 OG7 Tb927.11.1900 ↔ Tb927.2.4850 +7 more	Both
LAMA_000814900 ⚠ Proteasome subunit A N-terminal signature/Pro	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_005678 OG6 TCSYLVIO_004200 ↔ TCSYLVIO_005678 OG7 Tb927.10.6030 ↔ Tb927.11.1900 OG7 Tb927.10.230 ↔ Tb927.11.3240 +42 more	Both
LAMA_000172800 ⚠ Proteasome subunit A N-terminal signature/Pro	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_001707 OG6 TCSYLVIO_001707 ↔ TCSYLVIO_004200 OG7 Tb927.10.6030 ↔ Tb927.11.1900 OG7 Tb927.10.230 ↔ Tb927.11.3240 +42 more	Both
LAMA_000213000 ⚠ Proteasome subunit A N-terminal signature/Pro	—	OG6 Tb927.7.4420 ↔ Tb927.8.3150 OG7 Tb927.10.6030 ↔ Tb927.11.1900 OG7 Tb927.10.230 ↔ Tb927.11.3240 OG7 Tb927.10.6030 ↔ Tb927.11.16760 +41 more	Both
LAMA_000595400 ⚠ HECT-domain (ubiquitin-transferase), putative	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_009791 OG7 TCSYLVIO_004584 ↔ TCSYLVIO_009791 OG7 TCSYLVIO_003488 ↔ TCSYLVIO_009791 OG7 TCSYLVIO_008271 ↔ TCSYLVIO_009791 +4 more	OG7
LAMA_000707400 ⚠ Axonemal dynein light chain, putative	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001495 OG7 TCSYLVIO_001495 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001495 ↔ TCSYLVIO_004200 OG7 TCSYLVIO_001495 ↔ TCSYLVIO_005500 +4 more	OG7
LAMA_000253000 ⚠ WW domain containing protein, putative	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_009791 OG7 TCSYLVIO_004584 ↔ TCSYLVIO_009791 OG7 TCSYLVIO_003488 ↔ TCSYLVIO_009791 OG7 TCSYLVIO_008271 ↔ TCSYLVIO_009791 +4 more	OG7
LAMA_000242200 ⚠ Galactose oxidase, central domain/Kelch motif	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001589 OG7 TCSYLVIO_001589 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001589 ↔ TCSYLVIO_004200 OG7 TCSYLVIO_001589 ↔ TCSYLVIO_005500 +4 more	OG7
LAMA_000403400 ⚠ PCI domain/26S proteasome regulatory subunit	—	OG7 Tb927.10.1550 ↔ Tb927.11.1900	OG7
LAMA_000323000 ⚠ Proteasome subunit, putative	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_005312 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_006999 OG7 TCSYLVIO_005312 ↔ TCSYLVIO_006999 +2 more	OG7
LAMA_000336300 ⚠ DEAD/DEAH box helicase/Type III restriction e	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_004479 OG7 TCSYLVIO_004479 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_004479 ↔ TCSYLVIO_008271	OG7
LAMA_000597100 ⚠ WW domain containing protein, putative	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_009791 OG7 TCSYLVIO_004584 ↔ TCSYLVIO_009791 OG7 TCSYLVIO_003488 ↔ TCSYLVIO_009791 OG7 TCSYLVIO_008271 ↔ TCSYLVIO_009791 +4 more	OG7
LAMA_000458300 ⚠ Kelch motif/Galactose oxidase, central domain	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001589 OG7 TCSYLVIO_001589 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001589 ↔ TCSYLVIO_004200 OG7 TCSYLVIO_001589 ↔ TCSYLVIO_005500 +4 more	OG7
LAMA_000562800 ⚠ Cid1 family poly A polymerase, putative	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_010483 OG7 TCSYLVIO_004584 ↔ TCSYLVIO_010483 OG7 TCSYLVIO_003488 ↔ TCSYLVIO_010483 OG7 TCSYLVIO_008271 ↔ TCSYLVIO_010483 +4 more	OG7
LAMA_000512800 ⚠ Axonemal dynein light chain, putative	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001495 OG7 TCSYLVIO_001495 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001495 ↔ TCSYLVIO_004200 OG7 TCSYLVIO_001495 ↔ TCSYLVIO_005500 +4 more	OG7
LAMA_000495500 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_006358 OG7 TCSYLVIO_004584 ↔ TCSYLVIO_006358 OG7 TCSYLVIO_003488 ↔ TCSYLVIO_006358 OG7 TCSYLVIO_005772 ↔ TCSYLVIO_006358 +4 more	OG7
LAMA_000076200 ⚠ Proteasome subunit, putative	—	OG6 Tb927.7.4790 ↔ Tb927.8.3150 OG7 Tb927.7.4790 ↔ Tb927.8.3150	Both
LAMA_000121400 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_231460.1 ↔ LdBPK_290740.1 OG6 LdBPK_290740.1 ↔ LdBPK_321060.1 OG7 LdBPK_290740.1 ↔ LdBPK_323470.1 OG7 LdBPK_290740.1 ↔ LdBPK_367240.1 +4 more	Both
LAMA_000572000 ⚠ HEAT repeats/26S proteasome regulatory subuni	—	OG6 Tb927.11.9220 ↔ Tb927.8.3150 OG7 Tb927.11.9220 ↔ Tb927.8.3150 OG7 Tb927.10.8190 ↔ Tb927.11.9220	Both
LAMA_000006500 ⚠ PMC2NT (NUC016) domain/3'-5' exonuclease/HRDC	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_008271	Both
LAMA_000244400 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_001198 OG6 TCSYLVIO_001198 ↔ TCSYLVIO_004200 OG7 TCSYLVIO_001198 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001198 ↔ TCSYLVIO_004200 +6 more	Both
LAMA_000133900 ⚠ N-terminal domain of ribose phosphate pyropho	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_008271 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_005312 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_004731 +2 more	OG7
LAMA_000014200 ⚠ Tubulin/FtsZ family, GTPase domain/Tubulin C-	—	OG7 Tb927.1.2330 ↔ Tb927.11.3240	OG7
LAMA_000488100 ⚠ Tubulin/FtsZ family, GTPase domain/Tubulin C-	—	OG7 Tb927.1.2330 ↔ Tb927.11.3240	OG7
LAMA_000407400 ⚠ Tubulin/FtsZ family, GTPase domain/Tubulin C-	—	OG7 Tb927.1.2330 ↔ Tb927.11.3240	OG7
LAMA_000357300 ⚠ Tubulin/FtsZ family, GTPase domain containing	—	OG7 Tb927.1.2330 ↔ Tb927.11.3240	OG7
LAMA_000541700 ⚠ WD domain, G-beta repeat, putative	—	OG7 Tb927.10.1060 ↔ Tb927.11.9610 OG7 Tb927.11.9610 ↔ Tb927.9.11270 OG7 Tb927.11.9610 ↔ Tb927.8.3150	OG7
LAMA_000683300 ⚠ 26S proteasome subunit RPN7/PCI domain contai	—	OG7 Tb927.10.1060 ↔ Tb927.11.16030	OG7
LAMA_000321000 ⚠ Kelch motif/Galactose oxidase, central domain	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001589 OG7 TCSYLVIO_001589 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001589 ↔ TCSYLVIO_004200 OG7 TCSYLVIO_001589 ↔ TCSYLVIO_005500 +4 more	OG7
LAMA_000380400 ⚠ Galactose oxidase, central domain/Kelch motif	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001589 OG7 TCSYLVIO_001589 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001589 ↔ TCSYLVIO_004200 OG7 TCSYLVIO_001589 ↔ TCSYLVIO_005500 +4 more	OG7
LAMA_000303100 ⚠ Cid1 family poly A polymerase, putative	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_010483 OG7 TCSYLVIO_004584 ↔ TCSYLVIO_010483 OG7 TCSYLVIO_003488 ↔ TCSYLVIO_010483 OG7 TCSYLVIO_008271 ↔ TCSYLVIO_010483 +4 more	OG7
LAMA_000820400 ⚠ SPRY domain/HECT-domain (ubiquitin-transferas	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_009791 OG7 TCSYLVIO_004584 ↔ TCSYLVIO_009791 OG7 TCSYLVIO_003488 ↔ TCSYLVIO_009791 OG7 TCSYLVIO_008271 ↔ TCSYLVIO_009791 +4 more	OG7
LAMA_000307500 ⚠ Elongation factor Tu GTP binding domain/Elong	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_004074 OG7 TCSYLVIO_003488 ↔ TCSYLVIO_004074 OG7 TCSYLVIO_004074 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_004074 ↔ TCSYLVIO_004200 +4 more	OG7
LAMA_000407500 ⚠ Axonemal dynein light chain, putative	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001495 OG7 TCSYLVIO_001495 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001495 ↔ TCSYLVIO_004200 OG7 TCSYLVIO_001495 ↔ TCSYLVIO_005500 +4 more	OG7
LAMA_000576500 ⚠ Galactose oxidase, central domain containing	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001589 OG7 TCSYLVIO_001589 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001589 ↔ TCSYLVIO_004200 OG7 TCSYLVIO_001589 ↔ TCSYLVIO_005500 +4 more	OG7
LAMA_000138300 ⚠ N-terminal domain of ribose phosphate pyropho	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_008271 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_005312 ↔ TCSYLVIO_010787 +3 more	Both
LAMA_000506300 ⚠ Nucleotidyltransferase domain/RNA editing 3'	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_010483 OG7 TCSYLVIO_004584 ↔ TCSYLVIO_010483 OG7 TCSYLVIO_003488 ↔ TCSYLVIO_010483 OG7 TCSYLVIO_008271 ↔ TCSYLVIO_010483 +4 more	OG7
LAMA_000571200 ⚠ Kelch motif/Galactose oxidase, central domain	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001589 OG7 TCSYLVIO_001589 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001589 ↔ TCSYLVIO_004200 OG7 TCSYLVIO_001589 ↔ TCSYLVIO_005500 +4 more	OG7

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