LAMA_000006500

PMC2NT (NUC016) domain/3'-5' exonuclease/HRDC domain containing protein, putative

Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_101473 OG7: OG7_0005093 41 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 41 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LAMA_000433200 ⚠ 3' exoribonuclease family, domain 1, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_003804 OG6 LdBPK_044330.1 ↔ LdBPK_221430.1 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_003804 OG7 LdBPK_044330.1 ↔ LdBPK_221430.1	Both
LAMA_000690100 ⚠ 3' exoribonuclease family, domain 1/3' exorib	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_003804 OG6 LdBPK_044330.1 ↔ LdBPK_221430.1 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_003804 OG7 LdBPK_044330.1 ↔ LdBPK_221430.1	Both
LAMA_000541800 ⚠ TCP-1/cpn60 chaperonin family, putative	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_008271	OG7
LAMA_000652000 Biotin carboxylase, N-terminal domain/Carbamo	—	OG6 TCSYLVIO_002772 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_002772 ↔ TCSYLVIO_003804	Both
LAMA_000789300 Helicase conserved C-terminal domain containi	—	OG6 TCSYLVIO_001373 ↔ TCSYLVIO_003804	OG6
LAMA_000555700 Proteasome subunit, putative	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_003804	Both
LAMA_000210000 KH domain containing protein, putative	—	OG6 LdBPK_044330.1 ↔ LdBPK_140010.1 OG7 LdBPK_044330.1 ↔ LdBPK_140010.1	Both
LAMA_000172800 ⚠ Proteasome subunit A N-terminal signature/Pro	—	OG6 TCSYLVIO_001707 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_009369	Both
LAMA_000805000 ⚠ TCP-1/cpn60 chaperonin family, putative	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_008271	OG7
LAMA_000377000 ⚠ TCP-1/cpn60 chaperonin family, putative	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_008271	OG7
LAMA_000209500 ⚠ TCP-1/cpn60 chaperonin family, putative	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_008271	OG7
LAMA_000664300 ⚠ TCP-1/cpn60 chaperonin family, putative	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_008271	Both
LAMA_000530500 ⚠ Proteasome subunit A N-terminal signature/Pro	—	OG7 TCSYLVIO_001707 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_009369	OG7
LAMA_000213000 ⚠ Proteasome subunit A N-terminal signature/Pro	—	OG7 TCSYLVIO_001707 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_009369	OG7
LAMA_000416900 ⚠ Proteasome subunit A N-terminal signature/Pro	—	OG7 TCSYLVIO_001707 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_009369	OG7
LAMA_000322400 ⚠ Proteasome subunit A N-terminal signature/Pro	—	OG7 TCSYLVIO_001707 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_009369	OG7
LAMA_000356300 ⚠ 3' exoribonuclease family, domain 1, putative	—	OG7 LdBPK_020290.1 ↔ LdBPK_044330.1	OG7
LAMA_000336500 ⚠ 3' exoribonuclease family, domain 1/3' exorib	—	OG7 LdBPK_020290.1 ↔ LdBPK_044330.1	OG7
LAMA_000336300 ⚠ DEAD/DEAH box helicase/Type III restriction e	—	OG7 TCSYLVIO_003804 ↔ TCSYLVIO_004479	OG7
LAMA_000323000 ⚠ Proteasome subunit, putative	—	OG7 TCSYLVIO_003804 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_006999	OG7
LAMA_000133900 ⚠ N-terminal domain of ribose phosphate pyropho	—	OG7 TCSYLVIO_003804 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_004731	OG7
LAMA_000221500 'Cold-shock' DNA-binding domain containing pr	—	OG6 TCSYLVIO_003804 ↔ TCSYLVIO_010606 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_010606	Both
LAMA_000012700 ⚠ 3' exoribonuclease family, domain 1, putative	—	OG6 LdBPK_020290.1 ↔ LdBPK_044330.1 OG7 LdBPK_020290.1 ↔ LdBPK_044330.1	Both
LAMA_000551000 ⚠ Phosducin/Thioredoxin, putative	—	OG6 TCSYLVIO_000453 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_000453 ↔ TCSYLVIO_003804	Both
LAMA_000684900 ⚠ Phosducin/Thioredoxin, putative	—	OG6 TCSYLVIO_000453 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_000453 ↔ TCSYLVIO_003804	Both
LAMA_000715600 ⚠ N-terminal domain of ribose phosphate pyropho	—	OG6 TCSYLVIO_003804 ↔ TCSYLVIO_004731 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_004731	Both
LAMA_000416000 ⚠ Proteasome subunit A N-terminal signature/Pro	—	OG6 TCSYLVIO_003804 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_009369	Both
LAMA_000183900 ⚠ Proteasome subunit, putative	—	OG6 TCSYLVIO_003804 ↔ TCSYLVIO_006999 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_006999	Both
LAMA_000113700 hypothetical protein, conserved	—	OG6 TCSYLVIO_003804 ↔ TCSYLVIO_004312 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_004312	Both
LAMA_000360300 ⚠ N-terminal domain of ribose phosphate pyropho	—	OG6 TCSYLVIO_003804 ↔ TCSYLVIO_004731 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_004731	Both
LAMA_000732800 Domain found in IF2B/IF5, putative	—	OG6 TCSYLVIO_003804 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_004556	Both
LAMA_000051500 KH domain containing protein, putative	—	OG6 LdBPK_040130.1 ↔ LdBPK_044330.1 OG7 LdBPK_040130.1 ↔ LdBPK_044330.1	Both
LAMA_000408000 ⚠ TCP-1/cpn60 chaperonin family, putative	—	OG6 TCSYLVIO_003804 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_008271	Both
LAMA_000804800 ⚠ Proteasome subunit, putative	—	OG6 TCSYLVIO_003804 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_006999	Both
LAMA_000814900 ⚠ Proteasome subunit A N-terminal signature/Pro	—	OG6 TCSYLVIO_003804 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_009369	Both
LAMA_000688200 ⚠ TCP-1/cpn60 chaperonin family, putative	—	OG6 TCSYLVIO_003804 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_008271	Both
LAMA_000047100 ⚠ DEAD/DEAH box helicase/Type III restriction e	—	OG6 TCSYLVIO_003804 ↔ TCSYLVIO_004479 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_004479	Both
LAMA_000138300 ⚠ N-terminal domain of ribose phosphate pyropho	—	OG6 TCSYLVIO_003804 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_004731	Both
LAMA_000041700 Acetyltransferase (GNAT) family/Acetyltransfe	—	OG6 TCSYLVIO_003804 ↔ TCSYLVIO_004519 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_004519	Both
LAMA_000173000 hypothetical protein, conserved	—	OG6 TCSYLVIO_001704 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_001704 ↔ TCSYLVIO_003804	Both
LAMA_000448800 ⚠ TCP-1/cpn60 chaperonin family, putative	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_003804 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_008271	Both