LAMA_000571100

Thiamine pyrophosphate enzyme, N-terminal TPP binding domain/Thiamine pyrophosphate enzyme, C-terminal TPP binding domain containing protein, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_111322 OG7: OG7_0014458 47 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 47 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000498700 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
LAMA_000088300
Insulinase (Peptidase family M16)/Peptidase M
— Both
LAMA_000274600 ⚠
Galactose mutarotase-like/Glycosyl hydrolases
— Both
LAMA_000018800
PCRF domain/RF-1 domain containing protein, p
— Both
LAMA_000320300
The ARF-like 2 binding protein BART, putative
— Both
LAMA_000031900 ⚠
Insulinase (Peptidase family M16)/Peptidase M
— Both
LAMA_000416500
hypothetical protein, conserved
— Both
LAMA_000307700
SET domain containing protein, putative
— Both
LAMA_000199100
U-box domain containing protein, putative
— Both
LAMA_000452900
hypothetical protein, conserved
— Both
LAMA_000455000 ⚠
Poly A polymerase regulatory subunit, putativ
— OG7
LAMA_000703200 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
LAMA_000670800
NAD synthase, putative
— Both
LAMA_000104400 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
LAMA_000504100 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
LAMA_000790000 ⚠
CAF1 family ribonuclease, putative
— OG7
LAMA_000801900 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
LAMA_000792600 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
LAMA_000543600 ⚠
Phosphotransferase enzyme family/Choline/etha
— OG7
LAMA_000108800 ⚠
hypothetical protein
— OG7
LAMA_000780900 ⚠
Insulinase (Peptidase family M16)/Peptidase M
— OG7
LAMA_000655200 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
LAMA_000348100 ⚠
Glycosyl hydrolases family 31, putative
— OG7
LAMA_000375500 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
LAMA_000142500
hypothetical protein, conserved
— Both
LAMA_000430100
WD domain, G-beta repeat, putative
— Both
LAMA_000800500 ⚠
Poly A polymerase regulatory subunit, putativ
— Both
LAMA_000769800 ⚠
NLI interacting factor-like phosphatase, puta
— Both
LAMA_000440900 ⚠
CAF1 family ribonuclease, putative
— Both
LAMA_000272900
Peptidase C65 Otubain, putative
— Both
LAMA_000008700
hypothetical protein, conserved
— Both
LAMA_000577300
Gamma-glutamyl cyclotransferase, AIG2-like/Me
— Both
LAMA_000616600
Adenosylmethionine decarboxylase, putative
— Both
LAMA_000270400
UTP--glucose-1-phosphate uridylyltransferase,
— Both
LAMA_000048000
Ubiquitin-like domain containing protein, put
— Both
LAMA_000384400
HEAT repeats, putative
— Both
LAMA_000511900
hypothetical protein, conserved
— Both
LAMA_000064600
hypothetical protein, conserved
— Both
LAMA_000370600 ⚠
CAF1 family ribonuclease, putative
— Both
LAMA_000702300
hypothetical protein, conserved
— Both
LAMA_000441000 ⚠
CAF1 family ribonuclease, putative
— Both
LAMA_000781600 ⚠
Phosphotransferase enzyme family/Choline/etha
— Both
LAMA_000330400
Aminotransferase class I and II, putative
— Both
LAMA_000746500
Cofilin/tropomyosin-type actin-binding protei
— Both
LAMA_000620000 ⚠
DNA ligase N terminus/ATP dependent DNA ligas
— Both
LAMA_000523600
Aminotransferase class-V/Cys/Met metabolism P
— Both
LAMA_000697000
hypothetical protein, conserved
— Both
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.