LAMA_000274600

Galactose mutarotase-like/Glycosyl hydrolases family 31/Domain of unknown function (DUF5110), putative

Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_100592 OG7: OG7_0001836 117 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 117 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LAMA_000589800 ⚠ hypothetical protein	—	OG7 TCSYLVIO_004663 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_004663 ↔ TCSYLVIO_006141	OG7
LAMA_000018800 ⚠ PCRF domain/RF-1 domain containing protein, p	—	OG6 TCSYLVIO_006141 ↔ TCSYLVIO_006272 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_006272	Both
LAMA_000223300 ⚠ Serine hydroxymethyltransferase, putative	—	OG6 TCSYLVIO_006141 ↔ TCSYLVIO_010621 OG6 TCSYLVIO_006140 ↔ TCSYLVIO_010621 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_010621 OG7 TCSYLVIO_006140 ↔ TCSYLVIO_010621	Both
LAMA_000214300 ⚠ N-terminal conserved domain of Nudc./CS domai	—	OG6 TCSYLVIO_006141 ↔ TCSYLVIO_010327 OG6 TCSYLVIO_006140 ↔ TCSYLVIO_010327 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_010327 OG7 TCSYLVIO_006140 ↔ TCSYLVIO_010327	Both
LAMA_000224000 ⚠ tRNA synthetases class I (W and Y), putative	—	OG6 TCSYLVIO_006141 ↔ TCSYLVIO_010624 OG6 TCSYLVIO_006140 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_006140 ↔ TCSYLVIO_010624	Both
LAMA_000328500 ⚠ 16S rRNA methyltransferase RsmB/F, putative	—	OG6 TCSYLVIO_004998 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_004998 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_004998 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_004998 ↔ TCSYLVIO_006141	Both
LAMA_000103100 ⚠ 16S rRNA methyltransferase RsmB/F, putative	—	OG6 TCSYLVIO_004998 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_004998 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_004998 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_004998 ↔ TCSYLVIO_006141	Both
LAMA_000616600 ⚠ Adenosylmethionine decarboxylase, putative	—	OG6 TCSYLVIO_003342 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_003342 ↔ TCSYLVIO_006141	Both
LAMA_000571100 ⚠ Thiamine pyrophosphate enzyme, N-terminal TPP	—	OG6 TCSYLVIO_002596 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_002596 ↔ TCSYLVIO_006141	Both
LAMA_000800500 ⚠ Poly A polymerase regulatory subunit, putativ	—	OG6 TCSYLVIO_005809 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_005809 ↔ TCSYLVIO_006141	Both
LAMA_000771900 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_005084 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_005084 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_005084 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_005084 ↔ TCSYLVIO_006141	Both
LAMA_000306300 ⚠ Tetratricopeptide repeat, putative	—	OG6 TCSYLVIO_003496 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_003496 ↔ TCSYLVIO_006141	OG6
LAMA_000553400 ⚠ Tetratricopeptide repeat/Potential Monad-bind	—	OG6 TCSYLVIO_003496 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_003496 ↔ TCSYLVIO_006141	OG6
LAMA_000107300 ⚠ Thioredoxin-like domain/UDP-glucose:Glycoprot	—	OG6 TCSYLVIO_004363 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_004363 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_004363 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_004363 ↔ TCSYLVIO_006141	Both
LAMA_000479800 ⚠ Metallo-beta-lactamase superfamily domain/Cle	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_005414 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_006141	Both
LAMA_000432800 ⚠ tRNA synthetases class II (A)/Threonyl and Al	—	OG6 TCSYLVIO_001889 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_001889 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_001889 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_001889 ↔ TCSYLVIO_006141	Both
LAMA_000559100 ⚠ RNB domain containing protein, putative	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_002525 ↔ TCSYLVIO_006141 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_006141 +4 more	Both
LAMA_000064600 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_004813 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_004813 ↔ TCSYLVIO_006141	Both
LAMA_000694600 ⚠ Gar1/Naf1 RNA binding region containing prote	—	OG6 TCSYLVIO_000836 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_000836 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_006141	Both
LAMA_000070300 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001973 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_001973 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_001973 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_001973 ↔ TCSYLVIO_006141	Both
LAMA_000362600 ⚠ tRNA synthetases class I (I, L, M and V)/Anti	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006141	Both
LAMA_000452900 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_000215 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_000215 ↔ TCSYLVIO_006141	Both
LAMA_000172400 ⚠ Inorganic pyrophosphatase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006141	Both
LAMA_000049500 ⚠ Inorganic pyrophosphatase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006141	Both
LAMA_000297600 ⚠ ABC transporter, putative	—	OG6 TCSYLVIO_006012 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_006012 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_006012 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_006012 ↔ TCSYLVIO_006141	Both
LAMA_000053300 ⚠ RNB domain containing protein, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_006141	OG7
LAMA_000557900 ⚠ Rrp44-like cold shock domain/Dis3-like cold-s	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_006141	OG7
LAMA_000757200 ⚠ Metallo-beta-lactamase superfamily/Metallo-be	—	OG7 TCSYLVIO_005414 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_006141	OG7
LAMA_000698500 ⚠ ABC transporter, putative	—	OG7 TCSYLVIO_006012 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_006012 ↔ TCSYLVIO_006141	OG7
LAMA_000042000 ⚠ ABC transporter, putative	—	OG7 TCSYLVIO_006012 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_006012 ↔ TCSYLVIO_006141	OG7
LAMA_000504100 ⚠ NLI interacting factor-like phosphatase, puta	—	OG7 TCSYLVIO_006141 ↔ TCSYLVIO_007685	OG7
LAMA_000467600 ⚠ Elongation factor Tu GTP binding domain/50S r	—	OG7 TCSYLVIO_001768 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_006141	OG7
LAMA_000284400 ⚠ 16S rRNA methyltransferase RsmB/F, putative	—	OG7 TCSYLVIO_004998 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_004998 ↔ TCSYLVIO_006141	OG7
LAMA_000270000 ⚠ 16S rRNA methyltransferase RsmB/F, putative	—	OG7 TCSYLVIO_004998 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_004998 ↔ TCSYLVIO_006141	OG7
LAMA_000796100 ⚠ PPR repeat, putative	—	OG7 TCSYLVIO_000834 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_000834 ↔ TCSYLVIO_006141	OG7
LAMA_000310500 ⚠ Dihydrouridine synthase (Dus), putative	—	OG7 TCSYLVIO_006140 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_009102	OG7
LAMA_000375500 ⚠ NLI interacting factor-like phosphatase, puta	—	OG7 TCSYLVIO_006141 ↔ TCSYLVIO_007685	OG7
LAMA_000348100 ⚠ Glycosyl hydrolases family 31, putative	—	OG7 TCSYLVIO_006140 ↔ TCSYLVIO_006141	OG7
LAMA_000395000 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_006140 ↔ TCSYLVIO_006877 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_006877	OG7
LAMA_000655200 ⚠ NLI interacting factor-like phosphatase, puta	—	OG7 TCSYLVIO_006141 ↔ TCSYLVIO_007685	OG7
LAMA_000252800 ⚠ Putative tRNA binding domain containing prote	—	OG7 TCSYLVIO_006141 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_006140 ↔ TCSYLVIO_010624	OG7
LAMA_000792600 ⚠ NLI interacting factor-like phosphatase, puta	—	OG7 TCSYLVIO_006141 ↔ TCSYLVIO_007685	OG7
LAMA_000801900 ⚠ NLI interacting factor-like phosphatase, puta	—	OG7 TCSYLVIO_006141 ↔ TCSYLVIO_007685	OG7
LAMA_000740500 ⚠ Dihydrouridine synthase (Dus), putative	—	OG7 TCSYLVIO_006140 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_009102	OG7
LAMA_000641300 ⚠ Dihydrouridine synthase (Dus), putative	—	OG7 TCSYLVIO_006140 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_009102	OG7
LAMA_000406400 ⚠ OB-fold nucleic acid binding domain/tRNA synt	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_006141	OG7
LAMA_000422000 ⚠ Putative tRNA binding domain containing prote	—	OG7 TCSYLVIO_006141 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_006140 ↔ TCSYLVIO_010624	OG7
LAMA_000108800 ⚠ hypothetical protein	—	OG7 TCSYLVIO_003375 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_006141	OG7
LAMA_000590700 ⚠ OB-fold nucleic acid binding domain/tRNA synt	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_006141	OG7
LAMA_000592800 ⚠ CS domain containing protein, putative	—	OG7 TCSYLVIO_006141 ↔ TCSYLVIO_010327 OG7 TCSYLVIO_006140 ↔ TCSYLVIO_010327	OG7

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