LINF_170008800

cystathionine beta-synthase
Leishmania infantum JPCM5 OG6: OG6_100154 OG7: OG7_0002172 81 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 81 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LINF_270025600 ⚠
trypanothione synthetase - putative
— Both
LINF_230010700 ⚠
acetyl-CoA synthetase - putative
— +1 more Both
LINF_070014200 ⚠
N-acetylglucosamine-phosphate mutase - putati
— +2 more Both
LINF_230014800 ⚠
acetyl-CoA synthetase - putative
— +1 more Both
LINF_260013200 ⚠
aspartate--ammonia ligase - putative
— Both
LINF_360078300 ⚠
2 -3-bisphosphoglycerate-independent phosphog
— Both
LINF_130013600 ⚠
mitochondrial processing peptidase alpha subu
— OG7
LINF_210008800 ⚠
mitochondrial processing peptidase alpha subu
— OG7
LINF_090014600 ⚠
Uncharacterised protein family (UPF0160) - p
— OG6
LINF_290030100 ⚠
metallo-peptidase - Clan MA(E) Family M1
— Both
LINF_240027300 ⚠
3-hydroxy-3-methylglutaryl-CoA synthase - put
— Both
LINF_300018100 ⚠
pyridoxal kinase - putative
— Both
LINF_230014600 ⚠
3-ketoacyl-CoA thiolase - putative
— Both
LINF_220019000 ⚠
ribonucleoside-diphosphate reductase small ch
— Both
LINF_200011000 ⚠
cytidine triphosphate synthase - putative
— Both
LINF_340035100 ⚠
regulatory subunit of protein kinase a-like p
— OG7
LINF_290035800 ⚠
inosine-adenosine-guanosine-nucleosidehydrola
— Both
LINF_270027600 ⚠
ribonucleoside-diphosphate reductase small ch
— Both
LINF_040010800 ⚠
spermidine synthase
— Both
LINF_270027400 ⚠
branched-chain amino acid aminotransferase -
— Both
LINF_280036800 ⚠
cytosolic malate dehydrogenase
— Both
LINF_140008500 ⚠
threonine synthase - putative
— Both
LINF_330035400 ⚠
metallo-peptidase - Clan ME - Family M16
— Both
LINF_340044900 ⚠
serine palmitoyltransferase-like protein
— OG7
LINF_270014800
WD domain - G-beta repeat - putative
— OG7
LINF_360053800 ⚠
mitochondrial intermediate peptidase - putati
— OG7
LINF_330037600 ⚠
cysteine peptidase - Clan CA - family C51 - p
— OG7
LINF_260008000 ⚠
aminopeptidase-like protein
— OG7
LINF_350008300 ⚠
serine palmitoyltransferase - putative
— OG7
LINF_230009800 ⚠
trypanothione synthetase - putative
— OG7
LINF_120016700 ⚠
puromycin-sensitive aminopeptidase-like prote
— OG7
LINF_250031200 ⚠
CHAP domain/Glutathionylspermidine synthase p
— OG7
LINF_330037900 ⚠
cysteine peptidase - Clan CA - family C51 - p
— OG7
LINF_290027700 ⚠
NOL1/NOP2/sun family - putative
— OG7
LINF_150007700 ⚠
sterol carrier protein - putative
— OG7
LINF_150019400 ⚠
protein kinase - putative
— OG7
LINF_320046900 ⚠
cAMP response protein 1 - putative
— OG7
LINF_260025300 ⚠
Methyltransferase domain containing protein -
— OG7
LINF_340022200 ⚠
Protein of unknown function (DUF3808) - putat
— OG7
LINF_310007000 ⚠
nucleolar protein - putative
— OG7
LINF_250021500 ⚠
PUA domain/NOL1/NOP2/sun family - putative
— OG7
LINF_340021100 ⚠
d-isomer specific 2-hydroxyacid dehydrogenase
— Both
LINF_280023700 ⚠
NOL1/NOP2/sun family - putative
— OG7
LINF_280029600 ⚠
mitochondrial DNA topoisomerase II
— Both
LINF_250031600 ⚠
aminopeptidase P1 - putative
— Both
LINF_050015100 ⚠
3-mercaptopyruvate sulfurtransferase
— Both
LINF_360048000 ⚠
S-adenosylhomocysteine hydrolase
— Both
LINF_020005300 ⚠
aminopeptidase P1 - putative
— Both
LINF_330032000 ⚠
udp-glc 4'-epimerase - putative
— Both
LINF_360030700 ⚠
tyrosine aminotransferase
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.