LINF_260008200

C-1-tetrahydrofolate synthase - cytoplasmic - putative
Leishmania infantum JPCM5 OG6: OG6_100216 OG7: OG7_0002739 224 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 224 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LINF_180014100 ⚠
cyclosporin 16 - putative
— OG6
LINF_280007900 ⚠
DIS3-like exonuclease - putative
— OG6
LINF_050013400 ⚠
hypothetical protein - conserved
— OG6
LINF_220021600 ⚠
alanyl-tRNA synthetase - putative
— OG6
LINF_270030700 ⚠
GTP binding protein - putative
— Both
LINF_160005400 ⚠
Phytanoyl-CoA dioxygenase (PhyH)/2OG-Fe(II) o
— Both
LINF_220008200 ⚠
SEP domain containing protein - putative
— Both
LINF_230025500 ⚠
alanine racemase - putative
— Both
LINF_280017100 ⚠
electron-transfer-flavoprotein - alpha polype
— Both
LINF_280016800 ⚠
WD domain - G-beta repeat - putative
— Both
LINF_350012900 ⚠
aspartate aminotransferase - putative
— Both
LINF_240008500 ⚠
aspartate aminotransferase - putative
— Both
LINF_220018500 ⚠
translation initiation factor IF-2 - putative
— OG6
LINF_180005000 ⚠
kinetoplast polyadenylation/uridylation facto
— OG6
LINF_060015200 ⚠
glucosamine-fructose-6-phosphate aminotransfe
— OG6
LINF_220008000 ⚠
hypothetical protein - conserved
— OG6
LINF_310034100 ⚠
calreticulin - putative
— OG6
LINF_160013000 ⚠
transaldolase - putative
— Both
LINF_220006100 ⚠
GMP synthase [glutamine-hydrolysing]
— Both
LINF_130016000 ⚠
leucyl-tRNA synthetase - putative
— OG6
LINF_110011000 ⚠
hypothetical protein - conserved
— OG6
LINF_190012900 ⚠
ABC transport system ATP-binding protein - pu
— OG6
LINF_350009100 ⚠
hypothetical protein - conserved
— OG6
LINF_350015200 ⚠
protein kinase - putative
— OG6
LINF_350005300 ⚠
pyruvate kinase
— Both
LINF_330005900 ⚠
hypothetical protein - conserved
— Both
LINF_360078100 ⚠
hypothetical protein - conserved
— Both
LINF_300038700 ⚠
UV excision repair RAD23-like protein
— OG6
LINF_110007000 ⚠
acidocalcisomal pyrophosphatase
— Both
LINF_270013300 ⚠
UBA/TS-N domain containing protein - putative
— Both
LINF_140019600 ⚠
serine hydroxymethyltransferase (SHMT-L)
— OG6
LINF_320024000 ⚠
iron superoxide dismutase - putative
— Both
LINF_250006800 ⚠
cleavage and polyadenylation specificity fact
— OG6
LINF_340045400 ⚠
phosphomannomutase-like protein
— Both
LINF_250028200 ⚠
Translation initiation factor eIF3 subunit -
— OG6
LINF_200021600 ⚠
tRNA (Uracil-5-)-methyltransferase/Protein-L-
— OG6
LINF_360024300 ⚠
5'-3' exoribonuclease D - putative
— Both
LINF_270018900 ⚠
WD domain - G-beta repeat - putative
— Both
LINF_120005100 ⚠
PITH domain-containing protein
— Both
LINF_070015200 ⚠
serine/threonine kinase - putative
— Both
LINF_160011100 ⚠
dihydroorotase - putative
— Both
LINF_260032900 ⚠
6-phosphogluconolactonase
— Both
LINF_340028800 ⚠
asparaginyl-tRNA synthetase - putative
— OG6
LINF_280019500 ⚠
haloacid dehalogenase-like hydrolase - putati
— Both
LINF_180007900 ⚠
Dephospho-CoA kinase - putative
— Both
LINF_170009800 ⚠
Dihydrouridine synthase (Dus) - putative
— OG6
LINF_260029200 ⚠
Zn-finger in Ran binding protein and others/S
— Both
LINF_350005200 ⚠
pyruvate kinase
— Both
LINF_270030600 ⚠
protein phosphatase-like protein
— OG6
LINF_180005900 ⚠
alpha glucosidase II subunit - putative
— OG6
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.