LPAL13_260008000

C-1-tetrahydrofolate synthase, cytoplasmic, putative
Leishmania panamensis MHOM/COL/81/L13 OG6: OG6_100216 OG7: OG7_0002739 220 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 220 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LPAL13_310010500 ⚠
amino acid transporter aATP11, putative
— OG6
LPAL13_220017900 ⚠
alanyl-tRNA synthetase, putative
— OG6
LPAL13_160005400 ⚠
2OG-Fe(II) oxygenase superfamily, putative
— Both
LPAL13_220008200 ⚠
SEP domain containing protein, putative
— Both
LPAL13_230025700 ⚠
alanine racemase, putative
— Both
LPAL13_280018000 ⚠
electron-transfer-flavoprotein, alpha polypep
— Both
LPAL13_270031700 ⚠
GTP binding protein, putative
— Both
LPAL13_280017700 ⚠
WD domain, G-beta repeat, putative
— Both
LPAL13_240008900 ⚠
aspartate aminotransferase, putative
— Both
LPAL13_220014600 ⚠
translation initiation factor IF-2, putative
— OG6
LPAL13_340013000 ⚠
aspartate aminotransferase, putative
— Both
LPAL13_180005200 ⚠
kinetoplast polyadenylation/uridylation facto
— OG6
LPAL13_220008000 ⚠
hypothetical protein, conserved
— OG6
LPAL13_060015400 ⚠
glucosamine-fructose-6-phosphate aminotransfe
— OG6
LPAL13_310031700 ⚠
calreticulin, putative
— OG6
LPAL13_160011300 ⚠
transaldolase, putative
— Both
LPAL13_110009500 ⚠
hypothetical protein, conserved
— OG6
LPAL13_220006200 ⚠
glutamine amidotransferase, putative
— Both
LPAL13_130014400 ⚠
leucyl-tRNA synthetase, putative
— OG6
LPAL13_260014500 ⚠
Glucosidase II beta subunit-like protein, put
— OG6
LPAL13_350026500 ⚠
phosphomannomutase, putative
— OG6
LPAL13_340008900 ⚠
hypothetical protein, conserved
— OG6
LPAL13_060007900 ⚠
5'-3' exonuclease, putative
— Both
LPAL13_250027500 ⚠
hypothetical protein, conserved
— OG6
LPAL13_320015300 ⚠
ubiquitin-conjugating enzyme protein, putativ
— Both
LPAL13_300006900 ⚠
2-hydroxy-3-oxopropionate reductase, putative
— Both
LPAL13_250023000 ⚠
2,4-dihydroxyhept-2-ene-1,7-dioic acid aldola
— Both
LPAL13_200025600 ⚠
asparaginyl-tRNA synthetase, putative
— OG6
LPAL13_290027900 ⚠
NOL1/NOP2/sun family, putative
— OG6
LPAL13_300039000 ⚠
DNA ligase I, putative
— OG6
LPAL13_350024400 ⚠
exoribonuclease 2, putative
— Both
LPAL13_200009800 ⚠
Gamma-soluble NSF attachment protein (SNAP-ga
— Both
LPAL13_350005400 ⚠
stress-inducible protein STI1 homolog
— OG6
LPAL13_200007200 ⚠
deoxyhypusine synthase
— OG6
LPAL13_330005800 ⚠
hypothetical protein, conserved
— Both
LPAL13_180006000 ⚠
alpha glucosidase II subunit, putative
— OG6
LPAL13_250019700 ⚠
TAP42-like family, putative
— Both
LPAL13_340050800 ⚠
CS domain containing protein, putative
— Both
LPAL13_200005800 ⚠
CS domain containing protein, putative
— Both
LPAL13_080007800 ⚠
iron superoxide dismutase
— Both
LPAL13_350072600 ⚠
small G-protein, putative
— OG6
LPAL13_250024300 ⚠
hypothetical protein, conserved
— OG6
LPAL13_340047800 ⚠
Protein of unknown function (DUF2009), putati
— Both
LPAL13_260023400 ⚠
deoxyhypusine hydroxylase, putative
— Both
LPAL13_300015000 ⚠
conserved hypothetical protein, putative
— Both
LPAL13_350078100 ⚠
2,3-bisphosphoglycerate-independent phosphogl
— Both
LPAL13_140018600 ⚠
serine hydroxymethyltransferase (SHMT-L)
— OG6
LPAL13_350006200 ⚠
PUB domain containing protein, putative
— OG6
LPAL13_350054400 ⚠
Protein of unknown function (DUF2870), putati
— Both
LPAL13_100008100 ⚠
isocitrate dehydrogenase [NADP], mitochondria
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.