LTRL590_290026600

fumarate hydratase, putative

Leishmania tropica L590 OG6: OG6_102839 OG7: OG7_0008166 32 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 32 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LTRL590_290028600 ⚠ C-8 sterol isomerase-like protein	—	OG6 Tb927.3.4500 ↔ Tb927.3.4650 OG7 Tb927.3.4500 ↔ Tb927.3.4650	Both
LTRL590_360063500 ⚠ aldehyde dehydrogenase, putative	—	OG7 Tb927.3.4500 ↔ Tb927.6.4210	OG7
LTRL590_320037400 ⚠ nucleoside diphosphate kinase b	—	OG6 Tb927.11.16130 ↔ Tb927.11.5050 OG6 Tb927.11.16130 ↔ Tb927.3.4500 OG7 Tb927.11.16130 ↔ Tb927.11.5050 OG7 Tb927.11.16130 ↔ Tb927.3.4500	Both
LTRL590_140006300 ⚠ inosine-guanine nucleoside hydrolase, putativ	—	OG6 Tb927.3.4500 ↔ Tb927.7.4570 OG7 Tb927.3.4500 ↔ Tb927.7.4570	Both
LTRL590_350054300 ⚠ glyceraldehyde-3-phosphate dehydrogenase-like	—	OG6 Tb927.3.4500 ↔ Tb927.9.9820 OG7 Tb927.10.6880 ↔ Tb927.3.4500 OG7 Tb927.3.4500 ↔ Tb927.9.9820	Both
LTRL590_040009300 ⚠ adenylosuccinate lyase, putative	—	OG6 Tb927.11.5050 ↔ Tb927.9.7550 OG7 Tb927.11.5050 ↔ Tb927.9.7550	Both
LTRL590_180021100 ⚠ nonspecific nucleoside hydrolase	—	OG6 Tb927.3.4500 ↔ Tb927.7.4570 OG7 Tb927.3.4500 ↔ Tb927.7.4570	Both
LTRL590_290014800 ⚠ guanine deaminase, putative	—	OG6 Tb927.3.4500 ↔ Tb927.5.4560 OG7 Tb927.3.4500 ↔ Tb927.5.4560	Both
LTRL590_350039500 ⚠ 6-phosphogluconate dehydrogenase, decarboxyla	—	OG6 Tb927.11.5050 ↔ Tb927.9.12110 OG7 Tb927.11.5050 ↔ Tb927.9.12110	Both
LTRL590_150016600 ⚠ glutamate dehydrogenase	—	OG6 Tb927.3.4500 ↔ Tb927.9.5900 OG7 Tb927.3.4500 ↔ Tb927.9.5900	Both
LTRL590_240028600 ⚠ 3-hydroxy-3-methylglutaryl-CoA synthase, puta	—	OG6 Tb927.3.4500 ↔ Tb927.8.6110 OG6 Tb927.11.5050 ↔ Tb927.8.6110 OG7 Tb927.3.4500 ↔ Tb927.8.6110 OG7 Tb927.11.5050 ↔ Tb927.8.6110	Both
LTRL590_050012800 ⚠ methylthioadenosine phosphorylase, putative	—	OG6 Tb927.3.4500 ↔ Tb927.7.7040 OG6 Tb927.11.5050 ↔ Tb927.7.7040 OG7 Tb927.3.4500 ↔ Tb927.7.7040 OG7 Tb927.11.5050 ↔ Tb927.7.7040	Both
LTRL590_300041400 ⚠ aldehyde dehydrogenase, putative	—	OG6 Tb927.3.4500 ↔ Tb927.6.4210 OG7 Tb927.3.4500 ↔ Tb927.6.4210	Both
LTRL590_350036800 ⚠ glycerol kinase, glycosomal, putative	—	OG6 Tb927.3.4500 ↔ Tb927.9.12570 OG6 Tb927.11.5050 ↔ Tb927.9.12570 OG7 Tb927.3.4500 ↔ Tb927.9.12570 OG7 Tb927.11.5050 ↔ Tb927.9.12570	Both
LTRL590_300036200 ⚠ S-adenosylmethionine synthetase	—	OG6 Tb927.3.4500 ↔ Tb927.6.4840 OG7 Tb927.3.4500 ↔ Tb927.6.4840	Both
LTRL590_240028300 ⚠ transketolase	—	OG6 Tb927.3.4500 ↔ Tb927.8.6170 OG7 Tb927.3.4500 ↔ Tb927.8.6170	Both
LTRL590_130016200 ⚠ adenylosuccinate synthetase, putative	—	OG6 Tb927.11.3650 ↔ Tb927.3.4500 OG7 Tb927.11.3650 ↔ Tb927.3.4500	Both
LTRL590_240008200 ⚠ fumarate hydratase, putative	—	OG6 Tb927.11.5050 ↔ Tb927.3.4500 OG7 Tb927.11.5050 ↔ Tb927.3.4500	Both
LTRL590_120011900 ⚠ alanine aminotransferase	—	OG6 Tb927.1.3950 ↔ Tb927.11.5050 OG6 Tb927.1.3950 ↔ Tb927.3.4500 OG7 Tb927.1.3950 ↔ Tb927.11.5050 OG7 Tb927.1.3950 ↔ Tb927.3.4500	Both
LTRL590_180010400 ⚠ aconitase, putative	—	OG6 Tb927.10.14000 ↔ Tb927.11.5050 OG6 Tb927.10.14000 ↔ Tb927.3.4500 OG7 Tb927.10.14000 ↔ Tb927.11.5050 OG7 Tb927.10.14000 ↔ Tb927.3.4500	Both
LTRL590_050008300 ⚠ trypanothione reductase	—	OG6 Tb927.10.10390 ↔ Tb927.3.4500 OG7 Tb927.10.10390 ↔ Tb927.3.4500	Both
LTRL590_140019200 ⚠ enolase	—	OG6 Tb927.10.2890 ↔ Tb927.11.5050 OG6 Tb927.10.2890 ↔ Tb927.3.4500 OG7 Tb927.10.2890 ↔ Tb927.11.5050 OG7 Tb927.10.2890 ↔ Tb927.3.4500	Both
LTRL590_360031500 ⚠ glyceraldehyde 3-phosphate dehydrogenase, cyt	—	OG6 Tb927.10.6880 ↔ Tb927.3.4500 OG7 Tb927.10.6880 ↔ Tb927.3.4500 OG7 Tb927.3.4500 ↔ Tb927.9.9820	Both
LTRL590_320038700 ⚠ protein phosphatase 2A catalytic subunit, put	—	OG6 TCSYLVIO_004350 ↔ TCSYLVIO_005289	OG6
LTRL590_280034300 ⚠ protein phosphatase 4 catalytic subunit, puta	—	OG6 TCSYLVIO_004350 ↔ TCSYLVIO_005289	OG6
LTRL590_140010300 ⚠ cystathionine beta-lyase-like protein	—	OG6 TCSYLVIO_004350 ↔ TCSYLVIO_005821 OG7 TCSYLVIO_004350 ↔ TCSYLVIO_005821	Both
LTRL590_360024400 ⚠ aldehyde dehydrogenase, putative	—	OG6 TCSYLVIO_004350 ↔ TCSYLVIO_004949 OG7 TCSYLVIO_004350 ↔ TCSYLVIO_004949	Both
LTRL590_350038400 ⚠ cystathione gamma lyase, putative	—	OG6 TCSYLVIO_004350 ↔ TCSYLVIO_005821 OG7 TCSYLVIO_004350 ↔ TCSYLVIO_005821	Both
LTRL590_180012400 ⚠ citrate synthase, putative	—	OG6 Tb927.10.13430 ↔ Tb927.11.5050 OG7 Tb927.10.13430 ↔ Tb927.11.5050	Both
LTRL590_240013500 ⚠ malic enzyme, putative	—	OG6 Tb927.11.5440 ↔ Tb927.3.4500 OG6 Tb927.11.5050 ↔ Tb927.11.5440 OG7 Tb927.11.5440 ↔ Tb927.3.4500 OG7 Tb927.11.5050 ↔ Tb927.11.5440	Both
LTRL590_180012300 ⚠ citrate synthase, putative	—	OG6 Tb927.10.13430 ↔ Tb927.11.5050 OG7 Tb927.10.13430 ↔ Tb927.11.5050	Both
LTRL590_240013400 ⚠ malic enzyme, putative	—	OG6 Tb927.11.5440 ↔ Tb927.3.4500 OG6 Tb927.11.5050 ↔ Tb927.11.5440 OG7 Tb927.11.5440 ↔ Tb927.3.4500 OG7 Tb927.11.5050 ↔ Tb927.11.5440	Both