LTRL590_340044700

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative

Leishmania tropica L590 OG6: OG6_146732 OG7: OG7_0002830 159 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 159 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LTRL590_190014500 ⚠ phenylalanyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_005548 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_240010.1	OG7
LTRL590_240027900 ⚠ tubulin folding cofactor D, putative	—	OG7 LdBPK_240010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_007262	OG7
LTRL590_230012300 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
LTRL590_360076300 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
LTRL590_350028800 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
LTRL590_120007800 ⚠ cysteinyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_240010.1	OG7
LTRL590_240005100 ⚠ pyruvate dehydrogenase (lipoamide) kinase, pu	—	OG7 Tb927.1.1000 ↔ Tb927.11.4780 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007262	OG7
LTRL590_200008100 ⚠ developmentally regulated phosphoprotein-like	—	OG7 Tb927.1.1000 ↔ Tb927.11.4780 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007262	OG7
LTRL590_290031300 ⚠ aspartyl aminopeptidase, putative	—	OG7 LdBPK_240010.1 ↔ LdBPK_292470.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004406	OG7
LTRL590_340027400 ⚠ asparaginyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
LTRL590_300010300 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
LTRL590_210016500 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
LTRL590_230020700 ⚠ coronin, putative	—	OG7 TCSYLVIO_000174 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000174 ↔ TCSYLVIO_007262	OG7
LTRL590_030014700 ⚠ inorganic pyrophosphatase, putative	—	OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_001709	OG7
LTRL590_350013200 ⚠ NADH-dependent fumarate reductase, putative	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
LTRL590_070014900 ⚠ flavoprotein subunit-like protein	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
LTRL590_350017100 ⚠ NADH-dependent fumarate reductase, putative	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
LTRL590_350017000 ⚠ NADH-dependent fumarate reductase, putative	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
LTRL590_350054000 ⚠ Hsp70 protein, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005689	OG7
LTRL590_360064400 ⚠ adaptin, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004597 OG7 TCSYLVIO_004597 ↔ TCSYLVIO_007262	OG7
LTRL590_290013400 ⚠ heat shock protein 90, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009400 +2 more	OG7
LTRL590_280018200 ⚠ Hsp70 protein, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005689	OG7
LTRL590_110017300 ⚠ adaptin-related protein-like protein	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004597 OG7 TCSYLVIO_004597 ↔ TCSYLVIO_007262	OG7
LTRL590_320006800 ⚠ U2 small nuclear ribonucleoprotein 40K, putat	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006116	OG7
LTRL590_190019600 ⚠ FK506-binding protein (FKBP)-type peptidyl-pr	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005957	OG7
LTRL590_280035400 ⚠ Hsp70 protein, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005689	OG7
LTRL590_360067800 ⚠ beta-adaptin protein, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004597 OG7 TCSYLVIO_004597 ↔ TCSYLVIO_007262	OG7
LTRL590_270019500 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005512 OG7 TCSYLVIO_005512 ↔ TCSYLVIO_007262	OG7
LTRL590_280015100 ⚠ oxidoreductase-like protein	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_002566	OG7
LTRL590_360032500 ⚠ dipeptidyl-peptidase 8-like serine peptidase,	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007536 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007536	OG7
LTRL590_330032300 ⚠ heat shock protein, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009400 +2 more	OG7
LTRL590_290005200 ⚠ transcription factor-like protein	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010728 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010728	OG7
LTRL590_280018100 ⚠ heat-shock protein hsp70, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005689	OG7
LTRL590_260013700 ⚠ heat shock 70 protein-like protein	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005689	OG7
LTRL590_080007400 ⚠ ubiquitin-activating enzyme-like protein	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010542 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010542	OG7
LTRL590_360040400 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009198 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009198	OG7
LTRL590_120014900 ⚠ arginine N-methyltransferase-like protein	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006901	OG7
LTRL590_360012800 ⚠ Protein C21orf2 homolog, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006116	OG7
LTRL590_150008100 ⚠ ribonucleoprotein p18, mitochondrial precurso	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_002426 OG7 TCSYLVIO_002426 ↔ TCSYLVIO_007262	OG7
LTRL590_360007500 ⚠ peptidyl-prolyl cis-trans isomerase, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005957	OG7
LTRL590_220018600 ⚠ fk506-binding protein 1-like protein	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005957	OG7
LTRL590_190013700 ⚠ peptidyl-prolyl cis-trans isomerase, macropha	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005957	OG7
LTRL590_180018800 ⚠ heat shock protein 110, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005689	OG7
LTRL590_010012700 ⚠ ubiquitin activating enzyme, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010542 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010542	OG7
LTRL590_360017600 ⚠ endonuclease/exonuclease/phosphatase, putativ	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007569	OG7
LTRL590_160005300 ⚠ arginine N-methyltransferase, type I	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006901	OG7
LTRL590_340015800 ⚠ uracil phosphoribosyltransferase, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003952	OG7
LTRL590_060014100 ⚠ arginine N-methyltransferase, type III, putat	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006901	OG7
LTRL590_290019400 ⚠ Hsp70 protein/TPR repeat, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005957	OG7
LTRL590_350039200 ⚠ occurring C-terminal to leucine-rich repeats,	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006116	OG7

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