LbrM.23.0580

acetyl-CoA synthetase, putative
Leishmania braziliensis MHOM/BR/75/M2904 OG6: OG6_100430 OG7: OG7_0000501 46 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 46 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LbrM.17.0230 ⚠
cystathionine beta-synthase (fragment)
— +1 more Both
LbrM.35.3820 ⚠
cysteine synthase
— Both
LbrM.24.0780 ⚠
malic enzyme
— Both
LbrM.35.5830 ⚠
aminopeptidase P1, putative, metallo-peptidas
— OG7
LbrM.27.1990 ⚠
paraflagellar rod protein 5, putative
— Both
LbrM.28.2990 ⚠
heat-shock protein hsp70, putative
— Both
LbrM.34.2300 ⚠
metallo-peptidase, Clan MG, Family M24, amino
— Both
LbrM.18.0770 ⚠
citrate synthase, putative
— Both
LbrM.18.0760 ⚠
citrate synthase, putative
— Both
LbrM.14.1210 ⚠
Protein of unknown function (DUF3808), putati
— OG7
LbrM.28.1910 ⚠
NOL1/NOP2/sun family, putative
— OG7
LbrM.29.1970 ⚠
hypothetical protein, conserved
— OG7
LbrM.26.1920 ⚠
methyltransferase domain containing protein,
— OG7
LbrM.31.0300 ⚠
nucleolar protein, putative
— OG7
LbrM.25.2590 ⚠
PUA domain/NOL1/NOP2/sun family, putative
— OG7
LbrM.26.0910 ⚠
chaperone protein-like protein, heat shock 70
— OG7
LbrM.01.0790 ⚠
HSP70-like protein
— OG7
LbrM.33.3140 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
LbrM.31.0160 ⚠
paraflagellar rod protein 1D
— OG7
LbrM.29.1830 ⚠
paraflagellar rod protein 1D, putative
— OG7
LbrM.23.0490 ⚠
trypanothione synthetase, putative
— OG7
LbrM.34.4680 ⚠
Hsp70 protein, putative
— OG7
LbrM.18.1400 ⚠
heat shock protein 110, putative
— OG7
LbrM.33.3110 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
LbrM.14.1300 ⚠
D-isomer specific 2-hydroxyacid dehydrogenase
— Both
LbrM.05.0340 ⚠
dual specificity phosphatase-like protein
— OG6
LbrM.31.0010 ⚠
5-methyltetrahydropteroyltriglutamate-homocys
— Both
LbrM.35.7340 ⚠
elks delta-like protein, hypothetical protein
— Both
LbrM.34.4040 ⚠
kinetoplastid kinetochore protein 3, putative
— Both
LbrM.32.2670 ⚠
NOL1/NOP2/sun family, putative
— Both
LbrM.30.3360 ⚠
hypothetical protein, conserved
— Both
LbrM.23.0800 ⚠
acetyl-CoA synthetase, putative
— Both
LbrM.30.3720 ⚠
Protein of unknown function (DUF3808), putati
— Both
LbrM.33.3530 ⚠
hypothetical protein, conserved
— Both
LbrM.29.1020 ⚠
5-histidylcysteine sulfoxide synthase, putati
— Both
LbrM.28.1300 ⚠
luminal binding protein 1 (BiP), putative
— Both
LbrM.20.1430 ⚠
d-isomer specific 2-hydroxyacid dehydrogenase
— Both
LbrM.26.1260 ⚠
heat shock protein 70-related protein
— Both
LbrM.27.2010 ⚠
trypanothione synthetase
— Both
LbrM.28.3030 ⚠
heat shock protein 70, putative
— OG6
LbrM.09.0920 ⚠
Uncharacterised protein family (UPF0160), put
— Both
LbrM.24.0790 ⚠
malic enzyme, putative
— Both
LbrM.29.0910 ⚠
guanine deaminase, putative
— Both
LbrM.28.2980 ⚠
heat-shock protein hsp70, putative (fragment)
— Both
LbrM.26.0840 ⚠
aspartate--ammonia ligase, putative, asparagi
— Both
LbrM.28.2970 ⚠
heat-shock protein hsp70, putative
— Both
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.