LbrM.17.0230

cystathionine beta-synthase (fragment)
Leishmania braziliensis MHOM/BR/75/M2904 OG6: OG6_100154 OG7: OG7_0002172 90 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 90 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LbrM.23.0580 ⚠
acetyl-CoA synthetase, putative
— +1 more Both
LbrM.04.0010 ⚠
phosphoacetylglucosamine mutase-like gene
— +2 more Both
LbrM.26.0840 ⚠
aspartate--ammonia ligase, putative, asparagi
— Both
LbrM.23.0800 ⚠
acetyl-CoA synthetase, putative
— +1 more Both
LbrM.27.2010 ⚠
trypanothione synthetase
— Both
LbrM.24.2190 ⚠
3-hydroxy-3-methylglutaryl-CoA synthase, puta
— Both
LbrM.28.3030 ⚠
heat shock protein 70, putative
— OG6
LbrM.30.1370 ⚠
pyridoxal kinase, putative
— Both
LbrM.27.2230 ⚠
ribonucleoside-diphosphate reductase small ch
— Both
LbrM.14.0350 ⚠
threonine synthase, putative
— Both
LbrM.35.7010 ⚠
2,3-bisphosphoglycerate-independent phosphogl
— Both
LbrM.27.2210 ⚠
branched-chain amino acid aminotransferase, p
— Both
LbrM.04.0630 ⚠
spermidine synthase, putative
— Both
LbrM.29.2850 ⚠
inosine-adenosine-guanosine-nucleosidehydrola
— Both
LbrM.27.0930
WD domain, G-beta repeat, putative
— OG7
LbrM.28.1300 ⚠
luminal binding protein 1 (BiP), putative
— OG6
LbrM.20.4800 ⚠
cytidine triphosphate synthase, putative, CTP
— Both
LbrM.28.3070 ⚠
cytosolic malate dehydrogenase
— Both
LbrM.22.1170 ⚠
ribonucleoside-diphosphate reductase small ch
— Both
LbrM.23.0840 ⚠
3-ketoacyl-CoA thiolase, putative
— Both
LbrM.29.2220 ⚠
Aminopeptidase M1, putative
— Both
LbrM.28.2980 ⚠
heat-shock protein hsp70, putative (fragment)
— OG6
LbrM.28.2970 ⚠
heat-shock protein hsp70, putative
— OG6
LbrM.33.2890 ⚠
Mitochondrial-processing peptidase subunit al
— Both
LbrM.28.2990 ⚠
heat-shock protein hsp70, putative
— OG6
LbrM.20.2440 ⚠
regulatory subunit of protein kinase a-like p
— OG7
LbrM.31.0010 ⚠
5-methyltetrahydropteroyltriglutamate-homocys
— Both
LbrM.35.4690 ⚠
mitochondrial intermediate peptidase, putativ
— OG7
LbrM.33.3110 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
LbrM.23.0490 ⚠
trypanothione synthetase, putative
— OG7
LbrM.34.0360 ⚠
serine palmitoyltransferase, putative
— OG7
LbrM.20.3330 ⚠
serine palmitoyltransferase-like protein
— OG7
LbrM.15.0270 ⚠
sterol carrier protein, putative, nonspecific
— OG7
LbrM.12.0930 ⚠
puromycin-sensitive aminopeptidase-like prote
— OG7
LbrM.33.3140 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
LbrM.26.0330 ⚠
metallo-peptidase, Clan MA(E), Family M1
— OG7
LbrM.09.0920 ⚠
Uncharacterised protein family (UPF0160), put
— OG6
LbrM.32.4210 ⚠
cAMP response protein 1, putative
— OG7
LbrM.25.2590 ⚠
PUA domain/NOL1/NOP2/sun family, putative
— OG7
LbrM.31.0300 ⚠
nucleolar protein, putative
— OG7
LbrM.15.1140 ⚠
protein kinase, putative
— OG7
LbrM.26.1920 ⚠
methyltransferase domain containing protein,
— OG7
LbrM.29.1970 ⚠
hypothetical protein, conserved
— OG7
LbrM.28.1910 ⚠
NOL1/NOP2/sun family, putative
— OG7
LbrM.14.1210 ⚠
Protein of unknown function (DUF3808), putati
— OG7
LbrM.13.0680 ⚠
metallo-peptidase, Clan ME, Family M16, mitoc
— OG7
LbrM.21.0400 ⚠
mitochondrial processing peptidase alpha subu
— OG7
LbrM.29.1020 ⚠
5-histidylcysteine sulfoxide synthase, putati
— Both
LbrM.35.4150 ⚠
S-adenosylhomocysteine hydrolase
— Both
LbrM.05.0950 ⚠
3-mercaptopyruvate sulfurtransferase (fragmen
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.