LbrM.24.0780

malic enzyme
Leishmania braziliensis MHOM/BR/75/M2904 OG6: OG6_100205 OG7: OG7_0002857 57 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 57 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LbrM.33.3110 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
LbrM.28.2970 ⚠
heat-shock protein hsp70, putative
— Both
LbrM.28.1300 ⚠
luminal binding protein 1 (BiP), putative
— Both
LbrM.28.2990 ⚠
heat-shock protein hsp70, putative
— Both
LbrM.12.0630 ⚠
alanine aminotransferase
— Both
LbrM.23.0580 ⚠
acetyl-CoA synthetase, putative
— Both
LbrM.23.0800 ⚠
acetyl-CoA synthetase, putative
— Both
LbrM.33.0320 ⚠
ATP-binding cassette sub-family F member 1, p
— Both
LbrM.30.1730 ⚠
hypothetical protein, conserved
— Both
LbrM.31.3470 ⚠
metallopeptidase, putative
— Both
LbrM.31.3520 ⚠
metallo-peptidase, Clan ME, Family M16
— Both
LbrM.27.2010 ⚠
trypanothione synthetase
— Both
LbrM.35.7010 ⚠
2,3-bisphosphoglycerate-independent phosphogl
— Both
LbrM.33.3140 ⚠
cysteine peptidase, Clan CA, family C51, puta
— OG7
LbrM.23.0490 ⚠
trypanothione synthetase, putative
— OG7
LbrM.17.0230 ⚠
cystathionine beta-synthase (fragment)
— OG6
LbrM.26.0910 ⚠
chaperone protein-like protein, heat shock 70
— OG7
LbrM.01.0790 ⚠
HSP70-like protein
— OG7
LbrM.11.0400 ⚠
aminopeptidase, putative, metallo-peptidase,
— OG7
LbrM.11.0410 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
LbrM.34.4680 ⚠
Hsp70 protein, putative
— OG7
LbrM.18.1400 ⚠
heat shock protein 110, putative
— OG7
LbrM.31.0160 ⚠
paraflagellar rod protein 1D
— OG7
LbrM.29.1830 ⚠
paraflagellar rod protein 1D, putative
— OG7
LbrM.35.5830 ⚠
aminopeptidase P1, putative, metallo-peptidas
— OG7
LbrM.32.2420 ⚠
U5 small nuclear ribonucleoprotein component,
— OG7
LbrM.25.1640 ⚠
elongation factor 2-like protein
— OG7
LbrM.19.1110 ⚠
ABC transport system ATP-binding protein, put
— OG7
LbrM.03.0170 ⚠
ABC transporter protein, putative
— OG7
LbrM.35.0250 ⚠
elongation factor 2
— Both
LbrM.18.0770 ⚠
citrate synthase, putative
— Both
LbrM.29.1930 ⚠
Fumarate hydratase class I, cytosolic
— Both
LbrM.25.1710 ⚠
succinyl-CoA synthetase alpha subunit, putati
— Both
LbrM.25.1700 ⚠
succinyl-CoA synthetase alpha subunit, putati
— Both
LbrM.34.3250 ⚠
6-phosphogluconate dehydrogenase, decarboxyla
— Both
LbrM.10.0310 ⚠
isocitrate dehydrogenase [NADP], mitochondria
— +2 more Both
LbrM.24.0320 ⚠
fumarate hydratase, putative
— Both
LbrM.18.0760 ⚠
citrate synthase, putative
— Both
LbrM.04.1000 ⚠
hypothetical protein, conserved
— Both
LbrM.14.1330 ⚠
enolase
— Both
LbrM.14.1320 ⚠
enolase
— Both
LbrM.34.2300 ⚠
metallo-peptidase, Clan MG, Family M24, amino
— Both
LbrM.35.0260 ⚠
elongation factor 2
— Both
LbrM.24.0790 ⚠
malic enzyme, putative
— Both
LbrM.35.0270 ⚠
elongation factor 2
— Both
LbrM.27.1990 ⚠
paraflagellar rod protein 5, putative
— Both
LbrM.18.0570 ⚠
aconitase, putative
— Both
LbrM.35.3170 ⚠
succinyl-CoA ligase [GDP-forming] beta-chain,
— Both
LbrM.33.2840 ⚠
metallo-peptidase, Clan MF, Family M17
— Both
LbrM.26.1260 ⚠
heat shock protein 70-related protein
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.