TcCLB.511741.50

C-1-tetrahydrofolate synthase, cytoplasmic, putative
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_100216 OG7: OG7_0002740 203 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 203 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.507993.150 ⚠
Activator of Hsp90 ATPase, N-terminal/Activat
— OG6
TcCLB.509123.30 ⚠
kinetoplast polyadenylation/uridylation facto
— Both
TcCLB.399033.19 ⚠
kinetoplast polyadenylation/uridylation facto
— Both
TcCLB.511693.70 ⚠
hypothetical protein, conserved
— OG6
TcCLB.509011.40 ⚠
calreticulin, putative
— Both
TcCLB.506773.80 ⚠
hypothetical protein, conserved
— Both
TcCLB.508215.9 ⚠
protein kinase C substrate protein, heavy cha
— Both
TcCLB.503477.20 ⚠
transaldolase, putative
— OG6
TcCLB.508085.10 ⚠
GMP synthase, putative
— OG6
TcCLB.511049.40 ⚠
leucyl-tRNA synthetase, putative
— Both
TcCLB.509965.110 ⚠
importin alpha, putative
— Both
TcCLB.510599.30 ⚠
Component of IIS longevity pathway SMK-1, put
— Both
TcCLB.506945.40 ⚠
hypothetical protein, conserved
— OG6
TcCLB.509669.90 ⚠
XPC-binding domain/UBA/TS-N domain containing
— Both
TcCLB.509551.70 ⚠
Co-chaperone protein P23
— OG6
TcCLB.504147.30 ⚠
Protein of unknown function (DUF2870), putati
— OG6
TcCLB.509453.4 ⚠
hypothetical protein, conserved
— OG6
TcCLB.507941.100 ⚠
hypothetical protein, conserved
— OG6
TcCLB.511179.100 ⚠
monothiol glutaredoxin, putative
— OG6
TcCLB.511625.40 ⚠
protein phosphatase 2C, putative
— OG6
TcCLB.503425.20 ⚠
monothiol glutaredoxin, putative
— OG6
TcCLB.506363.130 ⚠
tRNA (Uracil-5-)-methyltransferase, putative
— Both
TcCLB.509247.50 ⚠
methionyl-tRNA synthetase, putative
— Both
TcCLB.503685.30 ⚠
carnitine/choline acetyltransferase, putative
— OG6
TcCLB.508955.20 ⚠
hypothetical protein, conserved
— Both
TcCLB.506525.80 ⚠
N-myristoyl transferase, putative
— OG6
TcCLB.506861.39 ⚠
dephospho-CoA kinase, putative (fragment)
— OG6
TcCLB.511751.200 ⚠
epsilon-adaptin, putative, AP-1/4 adapter com
— OG6
TcCLB.510181.9 ⚠
inositol-3-phosphate synthase, putative (frag
— Both
TcCLB.511303.34 ⚠
Macro domain containing protein, putative
— OG6
TcCLB.503589.10 ⚠
GDP-mannose pyrophosphorylase
— Both
TcCLB.503613.60 ⚠
acidocalcisomal pyrophosphatase, putative
— Both
TcCLB.504159.70 ⚠
hypothetical protein, conserved
— OG6
TcCLB.506351.9 ⚠
5'-3' exoribonuclease A, putative (fragment)
— OG6
TcCLB.507809.60 ⚠
hypothetical protein, conserved
— OG6
TcCLB.508347.130 ⚠
deoxyhypusine hydroxylase, putative
— OG6
TcCLB.506699.3 ⚠
NOL1/NOP2/sun family, putative
— Both
TcCLB.505945.5 ⚠
mitogen-activated protein kinase 3, putative
— OG6
TcCLB.507641.80 ⚠
5'-3' exoribonuclease D, putative
— OG6
TcCLB.511575.60 ⚠
isocitrate dehydrogenase [NADP], mitochondria
— OG6
TcCLB.506591.20 ⚠
U-box domain protein, putative
— OG6
TcCLB.509953.9 ⚠
ubiquitin carboxyl-terminal hydrolase, putati
— OG6
TcCLB.508373.20 ⚠
dihydroorotase, putative
— OG6
TcCLB.511573.40 ⚠
Mitogen-activated protein kinase 10, putative
— OG6
TcCLB.511801.50 ⚠
tRNA threonylcarbamoyl adenosine modification
— OG6
TcCLB.511041.4 ⚠
Sucrase/ferredoxin-like, putative
— OG6
TcCLB.511577.40 ⚠
35 kDa cyclophilin, putative, rotamase, putat
— OG6
TcCLB.510963.39 ⚠
PUB domain containing protein, putative
— Both
TcCLB.509767.90 ⚠
alanine racemase, putative
— OG6
TcCLB.511741.40 ⚠
RNA-binding protein, putative
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.