TcIL3000.11.7660

acidocalcisomal pyrophosphatase

Trypanosoma congolense IL3000 OG6: OG6_100346 OG7: OG7_0003350 320 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 320 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcIL3000_6_1480 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 Tb927.11.7060 ↔ Tb927.4.2310 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003867	OG7
TcIL3000_9_1520 ⚠ ubiquitin-activating enzyme E1, putative	—	OG7 Tb927.11.7060 ↔ Tb927.5.3430 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_010542	OG7
TcIL3000_10_1050 ⚠ OB-fold nucleic acid binding domain/tRNA synt	—	OG7 Tb927.11.7060 ↔ Tb927.4.2310 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003867	OG7
TcIL3000_10_12020 ⚠ pyruvate kinase 1, putative	—	OG6 Tb927.10.14140 ↔ Tb927.11.7060 OG6 TCSYLVIO_004455 ↔ TCSYLVIO_006133 OG7 Tb927.10.14140 ↔ Tb927.11.7060 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_006133	Both
TcIL3000_5_3890 ⚠ ubiquitin-activating enzyme E1, putative	—	OG6 Tb927.11.7060 ↔ Tb927.5.3430 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_010542 OG7 Tb927.11.7060 ↔ Tb927.5.3430 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_010542	Both
TcIL3000_0_18970 ⚠ cysteine peptidase, Clan CA, family C2, putat	—	OG6 Tb927.11.7060 ↔ Tb927.9.7540 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007342	OG6
TcIL3000_9_2550 ⚠ hypothetical protein	—	OG6 Tb927.11.7060 ↔ Tb927.9.7540 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007342	OG6
TcIL3000_0_54930 ⚠ cysteine peptidase, Clan CA, family C2, putat	—	OG6 Tb927.11.7060 ↔ Tb927.9.7540 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007342	OG6
TcIL3000_4_2130 ⚠ asparaginyl-tRNA synthetase, putative	—	OG6 Tb927.11.7060 ↔ Tb927.4.2310 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003867 OG7 Tb927.11.7060 ↔ Tb927.4.2310 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003867	Both
TcIL3000_9_2560 ⚠ cysteine peptidase, Clan CA, family C2, putat	—	OG6 Tb927.11.7060 ↔ Tb927.9.7540 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007342	OG6
TcIL3000_0_33830 ⚠ mitotic centromere-associated kinesin, putati	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_004455	OG7
TcIL3000_4_3480 ⚠ Kinesin-13 4, putative	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_004455	OG7
TcIL3000_0_49160 ⚠ mitotic centromere-associated kinesin, putati	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_004455	OG7
TcIL3000.11.14420 ⚠ phenylalanyl-tRNA synthetase alpha chain, put	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004213 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004213	Both
TcIL3000_7_5720 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_001973 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_001973	Both
TcIL3000_0_51320 ⚠ Possible lysine decarboxylase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_002403 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_002403	Both
TcIL3000_6_2120 ⚠ importin alpha subunit, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003173 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003173	Both
TcIL3000_9_4940 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_005810 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_005810	Both
TcIL3000_5_4970 ⚠ dihydrolipoamide branched chain transacylase,	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_009880 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_009880	Both
TcIL3000_9_350 ⚠ Zn-finger in Ran binding protein and others/S	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_005185 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_005185	Both
TcIL3000_10_4190 ⚠ Elongation factor G1, mitochondrial, putative	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_007487 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_007487	Both
TcIL3000_5_640 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_008502	Both
TcIL3000_0_26130 ⚠ Histidine kinase-, DNA gyrase B-, and HSP90-l	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_008621 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_009400 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_009151 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_008621 +2 more	Both
TcIL3000_0_26140 ⚠ Heat shock protein 83, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_008621 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_009400 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_009151 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_008621 +2 more	Both
TcIL3000_6_1350 ⚠ kinesin, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003093	OG6
TcIL3000_9_1440 ⚠ DNA-damage inducible protein DDI1-like protei	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003428 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003428	Both
TcIL3000_4_620 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003737 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003737	Both
TcIL3000_0_43380 ⚠ UDP-glucose:glycoprotein glucosyltransferase,	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004363 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004363	Both
TcIL3000_10_6100 ⚠ myo-inositol-1-phosphate synthase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007453	Both
TcIL3000.11.110 ⚠ cleavage and polyadenylation specificity fact	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_005414	Both
TcIL3000_10_12750 ⚠ C-terminal motor kinesin, putative (fragment)	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006065	OG6
TcIL3000_10_12240 ⚠ Histone chaperone Rttp106-like, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006113 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006113	Both
TcIL3000_3_2120 ⚠ NOL1/NOP2/sun family, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004998 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004998	Both
TcIL3000.11.890 ⚠ Nuclear pore complex protein 158 (fragment),	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007387 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007387	Both
TcIL3000_3_1620 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_004472 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_004472	Both
TcIL3000_3_3560 ⚠ Metallopeptidase family M24/FACT complex subu	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_010728 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_010728	Both
TcIL3000_0_07850 ⚠ Eukaryotic translation initiation factor 4E-1	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_005535 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_005535	Both
TcIL3000_0_28240 ⚠ cysteinyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006977 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006977	Both
TcIL3000_9_4310 ⚠ Protein of unknown function (DUF2009), putati	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_005744 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_005744	Both
TcIL3000_1_790 ⚠ Mitochondrial Editosome-like Complex TUTase	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_007293 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_007293	Both
TcIL3000.11.10550 ⚠ Biotin--acetyl-CoA-carboxylase ligase, putati	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_008176 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_008176	Both
TcIL3000_9_3760 ⚠ hypothetical protein	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_005710 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_005710	Both
TcIL3000_0_22360 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_008502	Both
TcIL3000_6_1570 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003118 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003118	Both
TcIL3000_0_16790 ⚠ calreticulin, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_002866 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_002866	Both
TcIL3000_0_35850 ⚠ ubiquitin ligase, putative (fragment)	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006542 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006542	Both
TcIL3000.11.8840 ⚠ DIS3-like exonuclease, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_002526 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_002525 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_002526 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_002525	Both
TcIL3000_10_2980 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_008502	Both
TcIL3000.11.10360 ⚠ Protein of unknown function (DUF2009), putati	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_005744 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_005744	Both
TcIL3000_0_27080 ⚠ 6-phosphogluconolactonase	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_007658 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_007658	Both

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