TcIL3000_6_210

ribosomal RNA processing protein 45, putative, exosome complex exonuclease, putative

Trypanosoma congolense IL3000 OG6: OG6_100420 OG7: OG7_0002825 83 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 83 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcIL3000_0_13330 ⚠ ribosomal RNA processing protein 4	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_010369 OG6 Tb927.6.670 ↔ Tb927.7.4670 OG6 Tb927.11.16600 ↔ Tb927.7.4670 OG6 LdBPK_140010.1 ↔ LdBPK_221430.1 +4 more	Both
TcIL3000_10_6420 ⚠ Ribosomal RNA processing protein 41A	—	OG6 Tb927.10.7450 ↔ Tb927.6.670 OG6 Tb927.10.7450 ↔ Tb927.11.16600 OG7 Tb927.11.16600 ↔ Tb927.2.2180 OG7 Tb927.10.7450 ↔ Tb927.6.670 +2 more	Both
TcIL3000_0_54840 ⚠ ribosomal RNA processing protein 41B, putativ	—	OG6 LdBPK_020290.1 ↔ LdBPK_221430.1 OG6 Tb927.11.16600 ↔ Tb927.2.2180 OG7 Tb927.11.16600 ↔ Tb927.2.2180 OG7 Tb927.10.7450 ↔ Tb927.6.670 +2 more	Both
TcIL3000_4_1200 ⚠ ribosomal RNA processing protein 6, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_003804 OG6 LdBPK_044330.1 ↔ LdBPK_221430.1 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_003804 OG7 LdBPK_044330.1 ↔ LdBPK_221430.1	Both
TcIL3000.11.11750 ⚠ exosome-associated protein 4	—	OG7 Tb927.11.16600 ↔ Tb927.2.2180 OG7 Tb927.10.7450 ↔ Tb927.6.670 OG7 Tb927.10.7450 ↔ Tb927.11.16600 OG7 LdBPK_020290.1 ↔ LdBPK_221430.1	OG7
TcIL3000_0_09310 ⚠ ribosomal RNA processing protein 6 (fragment)	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_003804 OG6 LdBPK_044330.1 ↔ LdBPK_221430.1 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_003804 OG7 LdBPK_044330.1 ↔ LdBPK_221430.1	Both
TcIL3000_0_54460 ⚠ heat shock 70 kDa protein, putative	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710	OG6
TcIL3000.11.7640 ⚠ proteasome alpha 7 subunit, putative	—	OG6 TCSYLVIO_001707 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	Both
TcIL3000_0_40200 ⚠ heat shock 70 kDa protein, putative	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710	OG6
TcIL3000_0_40210 ⚠ heat shock 70 kDa protein, putative (fragment	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710	OG6
TcIL3000.11.11980 ⚠ heat shock protein 70, putative	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710	OG6
TcIL3000.11.11940 ⚠ heat shock 70 kDa protein, putative	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710	OG6
TcIL3000_5_1110 ⚠ exosome component CSL4, putative	—	OG6 Tb927.11.16600 ↔ Tb927.5.1200 OG6 Tb927.5.1200 ↔ Tb927.6.670 OG7 Tb927.11.16600 ↔ Tb927.5.1200 OG7 Tb927.5.1200 ↔ Tb927.6.670	Both
TcIL3000.11.11990 ⚠ luminal binding protein 1 (BiP), putative	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710	OG6
TcIL3000_9_5840 ⚠ helicase, putative	—	OG6 TCSYLVIO_001373 ↔ TCSYLVIO_001893	OG6
TcIL3000_0_55930 ⚠ heat shock 70 kDa protein, putative	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710	OG6
TcIL3000_0_21650 ⚠ Hsp70 protein, putative (fragment)	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710	OG6
TcIL3000_0_02950 ⚠ heat shock 70 kDa protein, putative	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710	OG6
TcIL3000_0_40190 ⚠ heat shock protein 70 (hsp70), putative	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710	OG6
TcIL3000.11.16520 ⚠ exosome-associated protein 2	—	OG6 Tb927.11.16600 ↔ Tb927.6.670 OG7 Tb927.11.16600 ↔ Tb927.6.670	Both
TcIL3000_0_00860 ⚠ proteasome beta 3 subunit, putative	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_001893	Both
TcIL3000_0_05230 ⚠ proteasome beta 3 subunit, putative	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_001893	Both
TcIL3000_10_4890 ⚠ translation elongation factor 1-beta, putativ	—	OG6 Tb927.10.5840 ↔ Tb927.6.670 OG6 Tb927.10.5840 ↔ Tb927.11.16600 OG7 Tb927.10.5840 ↔ Tb927.6.670 OG7 Tb927.10.5840 ↔ Tb927.11.16600	Both
TcIL3000_0_04490 ⚠ adaptor complex protein (AP) 3 delta subunit	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_010530 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010530	Both
TcIL3000_10_5090 ⚠ proteasome subunit alpha type-1, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
TcIL3000_8_5360 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_006469	OG7
TcIL3000.11.1600 ⚠ T-complex protein 1, beta subunit, putative (	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	OG7
TcIL3000_7_3640 ⚠ proteasome alpha 3 subunit, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
TcIL3000_10_7080 ⚠ T-complex protein 1, theta subunit, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	OG7
TcIL3000_9_4650 ⚠ T-complex protein 1, eta subunit, putative, t	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	OG7
TcIL3000_0_60440 ⚠ ribose-phosphate pyrophosphokinase, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004731	OG7
TcIL3000_5_3590 ⚠ ribose-phosphate pyrophosphokinase, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004731	OG7
TcIL3000_10_13150 ⚠ DNA-directed RNA polymerases I and III subuni	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010718	OG7
TcIL3000_0_36040 ⚠ proteasome alpha 7 subunit	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
TcIL3000_0_51360 ⚠ RNA polymerase beta subunit/RNA polymerase Rp	—	OG7 Tb927.11.16600 ↔ Tb927.11.630 OG7 Tb927.11.630 ↔ Tb927.6.670	OG7
TcIL3000_10_6410 ⚠ ATP-dependent DEAD/H RNA helicase, putative,	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004479	OG7
TcIL3000_10_90 ⚠ proteasome subunit alpha type-5, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
TcIL3000_3_150 ⚠ proteasome alpha 7 subunit, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
TcIL3000_0_41470 ⚠ T-complex protein 1, zeta subunit, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	OG7
TcIL3000.11.3010 ⚠ T-complex protein 1, zeta subunit, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	OG7
TcIL3000_4_3350 ⚠ DNA-directed RNA polymerase II subunit 2, put	—	OG7 Tb927.11.16600 ↔ Tb927.11.630 OG7 Tb927.11.630 ↔ Tb927.6.670	OG7
TcIL3000_1_120 ⚠ DNA-directed RNA polymerase III, putative	—	OG7 Tb927.11.16600 ↔ Tb927.11.630 OG7 Tb927.11.630 ↔ Tb927.6.670	OG7
TcIL3000_0_29100 ⚠ DNA-directed RNA polymerase II subunit 2, put	—	OG7 Tb927.11.16600 ↔ Tb927.11.630 OG7 Tb927.11.630 ↔ Tb927.6.670	OG7
TcIL3000_0_32940 ⚠ DNA-directed RNA polymerase II subunit 2, put	—	OG7 Tb927.11.16600 ↔ Tb927.11.630 OG7 Tb927.11.630 ↔ Tb927.6.670	OG7
TcIL3000_8_3150 ⚠ T-complex protein 1, gamma subunit, putative	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	Both
TcIL3000_9_3500 ⚠ proteasome alpha 1 subunit, putative, 20S pro	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	Both
TcIL3000.11.710 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_007412 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_007412	Both
TcIL3000.11.12760 ⚠ hypothetical protein	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_006469 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_006469	Both
TcIL3000_3_1550 ⚠ hypothetical protein	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_004479 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004479	Both
TcIL3000_4_1510 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_003828 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_003828	Both

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