TcYC6_0074230

2-oxoglutarate dehydrogenase subunit, putative
Trypanosoma cruzi Y C6 OG6: OG6_100311 OG7: OG7_0003220 64 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 64 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0119350 ⚠
pyruvate dehydrogenase E1 beta subunit, putat
— Both
TcYC6_0117190 ⚠
hypothetical protein, conserved
— Both
TcYC6_0069410 ⚠
60S ribosomal subunit protein L31, putative
— Both
TcYC6_0069390 ⚠
60S ribosomal subunit protein L31, putative
— Both
TcYC6_0079810 ⚠
40S ribosomal protein S18, putative
— Both
TcYC6_0028020 ⚠
40S ribosomal protein S3, putative
— Both
TcYC6_0079800 ⚠
40S ribosomal protein S18, putative
— Both
TcYC6_0125180 ⚠
40S ribosomal protein S3, putative
— Both
TcYC6_0072190 ⚠
60S ribosomal protein L37, putative
— Both
TcYC6_0071730 ⚠
60S ribosomal protein L37, putative
— Both
TcYC6_0112490 ⚠
eukaryotic translation initiation factor 5, p
— Both
TcYC6_0005700 ⚠
40S ribosomal protein SA, putative
— Both
TcYC6_0005800 ⚠
40S ribosomal protein SA, putative
— Both
TcYC6_0126130 ⚠
60S ribosomal protein L37a, putative
— Both
TcYC6_0022100 ⚠
60S ribosomal protein L37a, putative
— Both
TcYC6_0006450 ⚠
2-oxoglutarate dehydrogenase E1 component, pu
— Both
TcYC6_0069400 ⚠
60S ribosomal subunit protein L31, putative
— Both
TcYC6_0085630 ⚠
cytochrome c oxidase subunit V, putative
— Both
TcYC6_0075710 ⚠
pre-mRNA splicing factor 19, putative
— Both
TcYC6_0107380 ⚠
Calpain-like protein 2
— OG6
TcYC6_0094060 ⚠
60S ribosomal protein L14, putative
— Both
TcYC6_0011320 ⚠
60S ribosomal protein L14, putative
— Both
TcYC6_0009330 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0127360 ⚠
dihydrolipoamide acetyltransferase precursor,
— OG7
TcYC6_0126490 ⚠
ATP-dependent RNA helicase DBP2A, putative
— OG7
TcYC6_0114670 ⚠
ATP-dependent RNA helicase HEL67
— OG7
TcYC6_0066250 ⚠
ATP-dependent DEAD/H RNA helicase
— OG7
TcYC6_0062920 ⚠
ATP-dependent DEAD/H RNA helicase, putative
— OG7
TcYC6_0014480 ⚠
DEAD-box ATP-dependent RNA helicase, mitochon
— OG7
TcYC6_0099660 ⚠
ATP-dependent DEAD/H RNA helicase, putative
— OG7
TcYC6_0114250 ⚠
RNA-binding protein, putative
— OG7
TcYC6_0115370 ⚠
60S ribosomal protein L7, putative
— OG7
TcYC6_0100420 ⚠
splicing factor TSR1, putative
— Both
TcYC6_0074560 ⚠
putative calpain-like cysteine peptidase
— Both
TcYC6_0074570 ⚠
putative calpain cysteine peptidase
— Both
TcYC6_0034540 ⚠
hypothetical protein, conserved
— OG6
TcYC6_0107970 ⚠
putative membrane associated protein
— Both
TcYC6_0057370 ⚠
60S ribosomal protein L7, putative
— Both
TcYC6_0058170 ⚠
60S ribosomal protein L7, putative
— Both
TcYC6_0075690 ⚠
hypothetical protein, conserved
— Both
TcYC6_0109730 ⚠
hypothetical protein, conserved
— Both
TcYC6_0089940 ⚠
ribosomal protein S19, putative
— Both
TcYC6_0089850 ⚠
eukaryotic translation initiation factor 3 su
— OG6
TcYC6_0093550 ⚠
hypothetical protein, conserved
— Both
TcYC6_0095380 ⚠
spliceosome-associated protein, putative
— Both
TcYC6_0100020 ⚠
60S ribosomal protein L7a, putative
— Both
TcYC6_0100010 ⚠
60S ribosomal protein L7a, putative
— Both
TcYC6_0049070 ⚠
translation initiation factor
— Both
TcYC6_0074550 ⚠
cysteine peptidase, Clan CA, family C2, putat
— Both
TcYC6_0115810 ⚠
60S ribosomal protein L10a, putative
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.