C4B63_120g42

Pseudouridylate synthase 7 homolog

Trypanosoma cruzi Dm28c 2018 OG6: OG6_139787 OG7: OG7_0042674 67 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 67 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_44g107 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.5990 ↔ Tb927.4.4610 OG6 TCSYLVIO_001604 ↔ TCSYLVIO_002910 OG7 Tb927.11.5990 ↔ Tb927.4.4610 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_002910	Both
C4B63_19g35 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.1630 ↔ Tb927.11.5990 OG6 TCSYLVIO_001604 ↔ TCSYLVIO_005482 OG7 Tb927.11.1630 ↔ Tb927.11.5990 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_005482	Both
C4B63_275g18 ⚠ nucleolar RNA helicase II(fragment)	—	OG6 Tb927.11.12930 ↔ Tb927.11.5990 OG6 TCSYLVIO_001604 ↔ TCSYLVIO_006554 OG7 Tb927.11.12930 ↔ Tb927.11.5990 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_006554	Both
C4B63_122g5 ⚠ ATP-dependent DEAD/H RNA helicase	—	OG6 Tb927.11.12930 ↔ Tb927.11.5990 OG6 TCSYLVIO_001604 ↔ TCSYLVIO_006554 OG7 Tb927.11.12930 ↔ Tb927.11.5990 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_006554	Both
C4B63_442g1 ⚠ ATP-dependent DEAD/H RNA helicase	—	OG6 Tb927.11.12930 ↔ Tb927.11.5990 OG6 TCSYLVIO_001604 ↔ TCSYLVIO_006554 OG7 Tb927.11.12930 ↔ Tb927.11.5990 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_006554	Both
C4B63_140g33 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.5990 ↔ Tb927.4.4610 OG6 TCSYLVIO_001604 ↔ TCSYLVIO_002910 OG7 Tb927.11.5990 ↔ Tb927.4.4610 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_002910	Both
C4B63_49g55 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.5990 ↔ Tb927.7.3460 OG6 TCSYLVIO_001604 ↔ TCSYLVIO_001807 OG7 Tb927.11.5990 ↔ Tb927.7.3460 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_001807	Both
C4B63_18g273 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.5990 ↔ Tb927.6.3930 OG6 TCSYLVIO_001604 ↔ TCSYLVIO_003296 OG7 Tb927.11.5990 ↔ Tb927.6.3930 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_003296	Both
C4B63_25g114 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.5990 ↔ Tb927.5.2070 OG6 TCSYLVIO_001604 ↔ TCSYLVIO_009032 OG7 Tb927.11.5990 ↔ Tb927.5.2070 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_009032	Both
C4B63_293g3 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.5990 ↔ Tb927.7.3460 OG6 TCSYLVIO_001604 ↔ TCSYLVIO_001807 OG7 Tb927.11.5990 ↔ Tb927.7.3460 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_001807	Both
C4B63_35g186 ⚠ 50S ribosomal protein L17	—	OG6 Tb927.11.5990 ↔ Tb927.8.5860 OG6 TCSYLVIO_001604 ↔ TCSYLVIO_007654 OG7 Tb927.11.5990 ↔ Tb927.8.5860 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_007654	Both
C4B63_8g543 ⚠ small GTP-binding protein	—	OG6 Tb927.11.5990 ↔ Tb927.7.1640 OG6 TCSYLVIO_001604 ↔ TCSYLVIO_002378 OG7 Tb927.11.5990 ↔ Tb927.7.1640 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_002378	Both
C4B63_129g45 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.5990 ↔ Tb927.4.4610 OG6 TCSYLVIO_001604 ↔ TCSYLVIO_002910 OG7 Tb927.11.5990 ↔ Tb927.4.4610 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_002910	Both
C4B63_31g78 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.5990 ↔ Tb927.5.3410 OG6 TCSYLVIO_001604 ↔ TCSYLVIO_010544 OG7 Tb927.11.5990 ↔ Tb927.5.3410 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_010544	Both
C4B63_243g4 ⚠ Present in the outer mitochondrial membrane p	—	OG6 TCSYLVIO_001604 ↔ TCSYLVIO_003157 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_003157	Both
C4B63_18g169 ⚠ Zinc finger CCCH domain-containing protein 47	—	OG6 TCSYLVIO_001604 ↔ TCSYLVIO_003384 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_003384	Both
C4B63_20g41 ⚠ ATP-dependent RNA helicase	—	OG6 TCSYLVIO_001604 ↔ TCSYLVIO_003932	OG6
C4B63_32g333 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001604 ↔ TCSYLVIO_007498 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_007498	Both
C4B63_72g100 ⚠ MRPL47	—	OG6 TCSYLVIO_001604 ↔ TCSYLVIO_007130 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_007130	Both
C4B63_72g90 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001604 ↔ TCSYLVIO_007121 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_007121	Both
C4B63_72g89 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001604 ↔ TCSYLVIO_007121 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_007121	Both
C4B63_93g76 ⚠ 40S ribosomal protein S11	—	OG6 TCSYLVIO_001604 ↔ TCSYLVIO_005773 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_005773	Both
C4B63_51g196 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001604 ↔ TCSYLVIO_002175 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_002175	Both
C4B63_51g197 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001604 ↔ TCSYLVIO_002175 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_002175	Both
C4B63_2g345 ⚠ GTP-binding protein	—	OG6 TCSYLVIO_001604 ↔ TCSYLVIO_005645 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_005645	Both
C4B63_15g5 ⚠ zinc-finger CCCH domain containing protein 11	—	OG7 TCSYLVIO_001604 ↔ TCSYLVIO_003384	OG7
C4B63_84g79 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001604 ↔ TCSYLVIO_004844 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_004844	Both
C4B63_2g691 ⚠ 30S Ribosomal protein S17	—	OG6 TCSYLVIO_001604 ↔ TCSYLVIO_005773 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_005773	Both
C4B63_9g446 ⚠ Probable methyltransferase TARBP1	—	OG7 TCSYLVIO_001604 ↔ TCSYLVIO_007498	OG7
C4B63_8g202 ⚠ GTP-binding protein	—	OG7 TCSYLVIO_001604 ↔ TCSYLVIO_005645	OG7
C4B63_91g35 ⚠ GTPase	—	OG7 TCSYLVIO_001604 ↔ TCSYLVIO_005645	OG7
C4B63_30g181 ⚠ rRNA methyltransferase 1, mitochondrial	—	OG7 TCSYLVIO_001604 ↔ TCSYLVIO_007498	OG7
C4B63_128g63 ⚠ GTP-binding protein	—	OG7 TCSYLVIO_001604 ↔ TCSYLVIO_005645	OG7
C4B63_83g24 ⚠ zinc-finger (CCCH type) protein	—	OG7 TCSYLVIO_001604 ↔ TCSYLVIO_003384	OG7
C4B63_56g32 ⚠ GTPase	—	OG7 TCSYLVIO_001604 ↔ TCSYLVIO_005645	OG7
C4B63_128g62 ⚠ 50S ribosome-binding GTPase	—	OG7 TCSYLVIO_001604 ↔ TCSYLVIO_005645	OG7
C4B63_128g61 ⚠ 50S ribosome-binding GTPase	—	OG7 TCSYLVIO_001604 ↔ TCSYLVIO_005645	OG7
C4B63_2g431 ⚠ GTPase protein	—	OG7 TCSYLVIO_001604 ↔ TCSYLVIO_005645	OG7
C4B63_397g11 ⚠ zinc-finger CCCH domain containing protein 11	—	OG7 TCSYLVIO_001604 ↔ TCSYLVIO_003384	OG7
C4B63_12g2035c ⚠ zinc-finger protein 2	—	OG7 TCSYLVIO_001604 ↔ TCSYLVIO_003384	OG7
C4B63_6g488 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.5990 ↔ Tb927.11.8040 OG7 Tb927.11.5990 ↔ Tb927.11.8040	Both
C4B63_72g91 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001604 ↔ TCSYLVIO_007121 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_007121	Both
C4B63_2g328 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.5990 ↔ Tb927.9.9310 OG7 Tb927.11.5990 ↔ Tb927.9.9310	Both
C4B63_7g348 ⚠ ribosomal protein L13	—	OG6 Tb927.11.5990 ↔ Tb927.4.1070 OG7 Tb927.11.5990 ↔ Tb927.4.1070	Both
C4B63_18g251 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.5990 ↔ Tb927.6.4080 OG7 Tb927.11.5990 ↔ Tb927.6.4080	Both
C4B63_40g98 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.10570 ↔ Tb927.11.5990 OG7 Tb927.11.10570 ↔ Tb927.11.5990	Both
C4B63_4g2225c ⚠ conserved hypothetical protein	—	OG6 Tb927.10.13770 ↔ Tb927.11.5990 OG7 Tb927.10.13770 ↔ Tb927.11.5990	Both
C4B63_16g110 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_000178 ↔ TCSYLVIO_001604 OG7 TCSYLVIO_000178 ↔ TCSYLVIO_001604	Both
C4B63_60g175 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001227 ↔ TCSYLVIO_001604 OG7 TCSYLVIO_001227 ↔ TCSYLVIO_001604	Both
C4B63_230g13 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.11470 ↔ Tb927.11.5990 OG7 Tb927.11.11470 ↔ Tb927.11.5990	Both

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