C4B63_19g35

conserved hypothetical protein

Trypanosoma cruzi Dm28c 2018 OG6: OG6_146640 OG7: OG7_0043140 84 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 84 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_140g33 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_002910 ↔ TCSYLVIO_005482 OG6 Tb927.11.1630 ↔ Tb927.4.4610 OG7 TCSYLVIO_002910 ↔ TCSYLVIO_005482 OG7 Tb927.11.1630 ↔ Tb927.4.4610	Both
C4B63_442g1 ⚠ ATP-dependent DEAD/H RNA helicase	—	OG6 TCSYLVIO_005482 ↔ TCSYLVIO_006554 OG6 Tb927.11.12930 ↔ Tb927.11.1630 OG7 TCSYLVIO_005482 ↔ TCSYLVIO_006554 OG7 Tb927.11.12930 ↔ Tb927.11.1630	Both
C4B63_35g186 50S ribosomal protein L17	—	OG6 TCSYLVIO_005482 ↔ TCSYLVIO_007654 OG6 Tb927.11.1630 ↔ Tb927.8.5860 OG7 TCSYLVIO_005482 ↔ TCSYLVIO_007654 OG7 Tb927.11.1630 ↔ Tb927.8.5860	Both
C4B63_51g196 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_002175 ↔ TCSYLVIO_005482 OG6 Tb927.11.1630 ↔ Tb927.11.4650 OG7 TCSYLVIO_002175 ↔ TCSYLVIO_005482 OG7 Tb927.11.1630 ↔ Tb927.11.4650	Both
C4B63_51g197 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_002175 ↔ TCSYLVIO_005482 OG6 Tb927.11.1630 ↔ Tb927.11.4650 OG7 TCSYLVIO_002175 ↔ TCSYLVIO_005482 OG7 Tb927.11.1630 ↔ Tb927.11.4650	Both
C4B63_44g107 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_002910 ↔ TCSYLVIO_005482 OG6 Tb927.11.1630 ↔ Tb927.4.4610 OG7 TCSYLVIO_002910 ↔ TCSYLVIO_005482 OG7 Tb927.11.1630 ↔ Tb927.4.4610	Both
C4B63_129g45 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_002910 ↔ TCSYLVIO_005482 OG6 Tb927.11.1630 ↔ Tb927.4.4610 OG7 TCSYLVIO_002910 ↔ TCSYLVIO_005482 OG7 Tb927.11.1630 ↔ Tb927.4.4610	Both
C4B63_122g5 ⚠ ATP-dependent DEAD/H RNA helicase	—	OG6 TCSYLVIO_005482 ↔ TCSYLVIO_006554 OG6 Tb927.11.12930 ↔ Tb927.11.1630 OG7 TCSYLVIO_005482 ↔ TCSYLVIO_006554 OG7 Tb927.11.12930 ↔ Tb927.11.1630	Both
C4B63_120g42 ⚠ Pseudouridylate synthase 7 homolog	—	OG6 Tb927.11.1630 ↔ Tb927.11.5990 OG6 TCSYLVIO_001604 ↔ TCSYLVIO_005482 OG7 Tb927.11.1630 ↔ Tb927.11.5990 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_005482	Both
C4B63_16g110 conserved hypothetical protein	—	OG6 Tb927.11.1630 ↔ Tb927.8.3170 OG6 TCSYLVIO_000178 ↔ TCSYLVIO_005482 OG7 Tb927.11.1630 ↔ Tb927.8.3170 OG7 TCSYLVIO_000178 ↔ TCSYLVIO_005482	Both
C4B63_275g18 ⚠ nucleolar RNA helicase II(fragment)	—	OG6 TCSYLVIO_005482 ↔ TCSYLVIO_006554 OG6 Tb927.11.12930 ↔ Tb927.11.1630 OG7 TCSYLVIO_005482 ↔ TCSYLVIO_006554 OG7 Tb927.11.12930 ↔ Tb927.11.1630	Both
C4B63_84g79 conserved hypothetical protein	—	OG6 Tb927.10.11050 ↔ Tb927.11.1630 OG6 TCSYLVIO_004844 ↔ TCSYLVIO_005482 OG7 TCSYLVIO_004844 ↔ TCSYLVIO_005482 OG7 Tb927.10.11050 ↔ Tb927.11.1630	Both
C4B63_12g257 ⚠ Pseudouridylate synthase 7 homolog	—	OG6 Tb927.11.1630 ↔ Tb927.11.5990 OG6 TCSYLVIO_001604 ↔ TCSYLVIO_005482 OG7 Tb927.11.1630 ↔ Tb927.11.5990 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_005482	Both
C4B63_60g175 conserved hypothetical protein	—	OG6 TCSYLVIO_001227 ↔ TCSYLVIO_005482 OG7 TCSYLVIO_001227 ↔ TCSYLVIO_005482	Both
C4B63_6g206 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.11470 ↔ Tb927.11.1630 OG7 Tb927.11.11470 ↔ Tb927.11.1630	Both
C4B63_230g13 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.11470 ↔ Tb927.11.1630 OG7 Tb927.11.11470 ↔ Tb927.11.1630	Both
C4B63_4g198 30S ribosomal protein S8 (mitochondrial)	—	OG6 Tb927.10.13300 ↔ Tb927.11.1630 OG7 Tb927.10.13300 ↔ Tb927.11.1630	Both
C4B63_49g55 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001807 ↔ TCSYLVIO_005482 OG7 TCSYLVIO_001807 ↔ TCSYLVIO_005482	Both
C4B63_57g103 conserved hypothetical protein	—	OG6 TCSYLVIO_005046 ↔ TCSYLVIO_005482 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_005482	Both
C4B63_293g3 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001807 ↔ TCSYLVIO_005482 OG7 TCSYLVIO_001807 ↔ TCSYLVIO_005482	Both
C4B63_18g273 conserved hypothetical protein	—	OG6 TCSYLVIO_003296 ↔ TCSYLVIO_005482 OG7 TCSYLVIO_003296 ↔ TCSYLVIO_005482	Both
C4B63_20g41 ATP-dependent RNA helicase	—	OG6 TCSYLVIO_003932 ↔ TCSYLVIO_005482	OG6
C4B63_12g390 conserved hypothetical protein	—	OG6 Tb927.11.1630 ↔ Tb927.3.820 OG7 Tb927.11.1630 ↔ Tb927.3.820	Both
C4B63_2g805 SpoU rRNA Methylase family	—	OG6 Tb927.11.1630 ↔ Tb927.9.12850 OG7 Tb927.11.1630 ↔ Tb927.9.12850	Both
C4B63_72g81 conserved hypothetical protein	—	OG6 Tb927.11.1630 ↔ Tb927.9.6910 OG7 Tb927.11.1630 ↔ Tb927.9.6910	Both
C4B63_83g74 conserved hypothetical protein	—	OG6 Tb927.11.1630 ↔ Tb927.5.1720 OG7 Tb927.11.1630 ↔ Tb927.5.1720	Both
C4B63_2g732 conserved hypothetical protein	—	OG6 Tb927.11.1630 ↔ Tb927.9.11880 OG7 Tb927.11.1630 ↔ Tb927.9.11880	Both
C4B63_30g181 ⚠ rRNA methyltransferase 1, mitochondrial	—	OG7 TCSYLVIO_005482 ↔ TCSYLVIO_007498	OG7
C4B63_303g15 ⚠ conserved hypothetical protein	—	OG6 Tb927.10.10400 ↔ Tb927.11.1630 OG7 Tb927.10.10400 ↔ Tb927.11.1630	Both
C4B63_12g2035c ⚠ zinc-finger protein 2	—	OG7 TCSYLVIO_003384 ↔ TCSYLVIO_005482	OG7
C4B63_397g11 ⚠ zinc-finger CCCH domain containing protein 11	—	OG7 TCSYLVIO_003384 ↔ TCSYLVIO_005482	OG7
C4B63_83g24 ⚠ zinc-finger (CCCH type) protein	—	OG7 TCSYLVIO_003384 ↔ TCSYLVIO_005482	OG7
C4B63_42g242 ⚠ 2-hydroxy-3-oxopropionate reductase	—	OG7 Tb927.11.1630 ↔ Tb927.3.970	OG7
C4B63_2g431 ⚠ GTPase protein	—	OG7 TCSYLVIO_005482 ↔ TCSYLVIO_005645	OG7
C4B63_128g61 ⚠ 50S ribosome-binding GTPase	—	OG7 TCSYLVIO_005482 ↔ TCSYLVIO_005645	OG7
C4B63_128g62 ⚠ 50S ribosome-binding GTPase	—	OG7 TCSYLVIO_005482 ↔ TCSYLVIO_005645	OG7
C4B63_56g32 ⚠ GTPase	—	OG7 TCSYLVIO_005482 ↔ TCSYLVIO_005645	OG7
C4B63_128g63 ⚠ GTP-binding protein	—	OG7 TCSYLVIO_005482 ↔ TCSYLVIO_005645	OG7
C4B63_69g21 pseudouridylate synthase-like protein	—	OG6 TCSYLVIO_003456 ↔ TCSYLVIO_005482 OG7 TCSYLVIO_003456 ↔ TCSYLVIO_005482	Both
C4B63_91g35 ⚠ GTPase	—	OG7 TCSYLVIO_005482 ↔ TCSYLVIO_005645	OG7
C4B63_8g202 ⚠ GTP-binding protein	—	OG7 TCSYLVIO_005482 ↔ TCSYLVIO_005645	OG7
C4B63_9g446 ⚠ Probable methyltransferase TARBP1	—	OG7 TCSYLVIO_005482 ↔ TCSYLVIO_007498	OG7
C4B63_17g241 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.14980 ↔ Tb927.11.1630 OG7 Tb927.11.14980 ↔ Tb927.11.1630	Both
C4B63_148g32 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.14980 ↔ Tb927.11.1630 OG7 Tb927.11.14980 ↔ Tb927.11.1630	Both
C4B63_40g36 Enoyl-CoA hydratase/isomerase family	—	OG6 Tb927.11.10150 ↔ Tb927.11.1630 OG7 Tb927.11.10150 ↔ Tb927.11.1630	Both
C4B63_9g442 kinteoplast poly(A) polymerase complex 1 subu	—	OG6 Tb927.11.15850 ↔ Tb927.11.1630 OG7 Tb927.11.15850 ↔ Tb927.11.1630	Both
C4B63_8g543 small GTP-binding protein	—	OG6 TCSYLVIO_002378 ↔ TCSYLVIO_005482 OG7 TCSYLVIO_002378 ↔ TCSYLVIO_005482	Both
C4B63_15g5 ⚠ zinc-finger CCCH domain containing protein 11	—	OG7 TCSYLVIO_003384 ↔ TCSYLVIO_005482	OG7
C4B63_304g15 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005482 ↔ TCSYLVIO_006046 OG7 TCSYLVIO_005482 ↔ TCSYLVIO_006046	Both
C4B63_2g691 ⚠ 30S Ribosomal protein S17	—	OG6 TCSYLVIO_005482 ↔ TCSYLVIO_005773 OG7 TCSYLVIO_005482 ↔ TCSYLVIO_005773	Both

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