C4B63_57g103

conserved hypothetical protein

Trypanosoma cruzi Dm28c 2018 OG6: OG6_146462 OG7: OG7_0042924 85 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 85 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_60g175 conserved hypothetical protein	—	OG6 Tb927.10.7380 ↔ Tb927.5.3980 OG6 TCSYLVIO_001227 ↔ TCSYLVIO_005046 OG7 Tb927.10.7380 ↔ Tb927.5.3980 OG7 TCSYLVIO_001227 ↔ TCSYLVIO_005046	Both
C4B63_275g18 ⚠ nucleolar RNA helicase II(fragment)	—	OG6 Tb927.10.7380 ↔ Tb927.11.12930 OG6 TCSYLVIO_005046 ↔ TCSYLVIO_006554 OG7 Tb927.10.7380 ↔ Tb927.11.12930 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_006554	Both
C4B63_442g1 ⚠ ATP-dependent DEAD/H RNA helicase	—	OG6 Tb927.10.7380 ↔ Tb927.11.12930 OG6 TCSYLVIO_005046 ↔ TCSYLVIO_006554 OG7 Tb927.10.7380 ↔ Tb927.11.12930 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_006554	Both
C4B63_10g521 mitochondrial ribosomal protein L3	—	OG6 Tb927.10.7380 ↔ Tb927.3.5610 OG6 TCSYLVIO_005046 ↔ TCSYLVIO_010727 OG7 Tb927.10.7380 ↔ Tb927.3.5610 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_010727	Both
C4B63_122g5 ⚠ ATP-dependent DEAD/H RNA helicase	—	OG6 Tb927.10.7380 ↔ Tb927.11.12930 OG6 TCSYLVIO_005046 ↔ TCSYLVIO_006554 OG7 Tb927.10.7380 ↔ Tb927.11.12930 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_006554	Both
C4B63_43g147 mitochondrial RNA binding complex 1 subunit	—	OG6 TCSYLVIO_005046 ↔ TCSYLVIO_009360 OG6 Tb927.10.380 ↔ Tb927.10.7380 OG7 Tb927.10.380 ↔ Tb927.10.7380 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_009360	Both
C4B63_140g33 ⚠ conserved hypothetical protein	—	OG6 Tb927.10.7380 ↔ Tb927.4.4610 OG6 TCSYLVIO_002910 ↔ TCSYLVIO_005046 OG7 Tb927.10.7380 ↔ Tb927.4.4610 OG7 TCSYLVIO_002910 ↔ TCSYLVIO_005046	Both
C4B63_129g45 ⚠ conserved hypothetical protein	—	OG6 Tb927.10.7380 ↔ Tb927.4.4610 OG6 TCSYLVIO_002910 ↔ TCSYLVIO_005046 OG7 Tb927.10.7380 ↔ Tb927.4.4610 OG7 TCSYLVIO_002910 ↔ TCSYLVIO_005046	Both
C4B63_44g107 ⚠ conserved hypothetical protein	—	OG6 Tb927.10.7380 ↔ Tb927.4.4610 OG6 TCSYLVIO_002910 ↔ TCSYLVIO_005046 OG7 Tb927.10.7380 ↔ Tb927.4.4610 OG7 TCSYLVIO_002910 ↔ TCSYLVIO_005046	Both
C4B63_72g100 MRPL47	—	OG6 Tb927.10.7380 ↔ Tb927.9.7170 OG6 TCSYLVIO_005046 ↔ TCSYLVIO_007130 OG7 Tb927.10.7380 ↔ Tb927.9.7170 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_007130	Both
C4B63_4g456 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005046 ↔ TCSYLVIO_006046 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_006046	Both
C4B63_93g76 ⚠ 40S ribosomal protein S11	—	OG6 TCSYLVIO_005046 ↔ TCSYLVIO_005773 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_005773	Both
C4B63_2g345 ⚠ GTP-binding protein	—	OG6 TCSYLVIO_005046 ↔ TCSYLVIO_005645 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_005645	Both
C4B63_35g186 50S ribosomal protein L17	—	OG6 TCSYLVIO_005046 ↔ TCSYLVIO_007654 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_007654	Both
C4B63_2g691 ⚠ 30S Ribosomal protein S17	—	OG6 TCSYLVIO_005046 ↔ TCSYLVIO_005773 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_005773	Both
C4B63_72g88 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005046 ↔ TCSYLVIO_007121 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_007121	Both
C4B63_72g90 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005046 ↔ TCSYLVIO_007121 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_007121	Both
C4B63_340g8 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005046 ↔ TCSYLVIO_007498 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_007498	Both
C4B63_31g78 conserved hypothetical protein	—	OG6 TCSYLVIO_005046 ↔ TCSYLVIO_010544 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_010544	Both
C4B63_11g71 conserved hypothetical protein	—	OG6 TCSYLVIO_005046 ↔ TCSYLVIO_006359 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_006359	Both
C4B63_19g35 conserved hypothetical protein	—	OG6 TCSYLVIO_005046 ↔ TCSYLVIO_005482 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_005482	Both
C4B63_31g116 conserved hypothetical protein	—	OG6 TCSYLVIO_005046 ↔ TCSYLVIO_010573 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_010573	Both
C4B63_304g15 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005046 ↔ TCSYLVIO_006046 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_006046	Both
C4B63_72g91 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005046 ↔ TCSYLVIO_007121 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_007121	Both
C4B63_43g163 ⚠ 40S ribosomal protein S11	—	OG6 TCSYLVIO_005046 ↔ TCSYLVIO_005773 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_005773	Both
C4B63_69g21 pseudouridylate synthase-like protein	—	OG6 TCSYLVIO_003456 ↔ TCSYLVIO_005046 OG7 TCSYLVIO_003456 ↔ TCSYLVIO_005046	Both
C4B63_91g35 ⚠ GTPase	—	OG7 TCSYLVIO_005046 ↔ TCSYLVIO_005645	OG7
C4B63_15g5 ⚠ zinc-finger CCCH domain containing protein 11	—	OG7 TCSYLVIO_003384 ↔ TCSYLVIO_005046	OG7
C4B63_12g2035c ⚠ zinc-finger protein 2	—	OG7 TCSYLVIO_003384 ↔ TCSYLVIO_005046	OG7
C4B63_397g11 ⚠ zinc-finger CCCH domain containing protein 11	—	OG7 TCSYLVIO_003384 ↔ TCSYLVIO_005046	OG7
C4B63_83g24 ⚠ zinc-finger (CCCH type) protein	—	OG7 TCSYLVIO_003384 ↔ TCSYLVIO_005046	OG7
C4B63_2g431 ⚠ GTPase protein	—	OG7 TCSYLVIO_005046 ↔ TCSYLVIO_005645	OG7
C4B63_128g61 ⚠ 50S ribosome-binding GTPase	—	OG7 TCSYLVIO_005046 ↔ TCSYLVIO_005645	OG7
C4B63_128g62 ⚠ 50S ribosome-binding GTPase	—	OG7 TCSYLVIO_005046 ↔ TCSYLVIO_005645	OG7
C4B63_56g32 ⚠ GTPase	—	OG7 TCSYLVIO_005046 ↔ TCSYLVIO_005645	OG7
C4B63_128g63 ⚠ GTP-binding protein	—	OG7 TCSYLVIO_005046 ↔ TCSYLVIO_005645	OG7
C4B63_30g181 ⚠ rRNA methyltransferase 1, mitochondrial	—	OG7 TCSYLVIO_005046 ↔ TCSYLVIO_007498	OG7
C4B63_72g89 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005046 ↔ TCSYLVIO_007121 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_007121	Both
C4B63_8g202 ⚠ GTP-binding protein	—	OG7 TCSYLVIO_005046 ↔ TCSYLVIO_005645	OG7
C4B63_9g446 ⚠ Probable methyltransferase TARBP1	—	OG7 TCSYLVIO_005046 ↔ TCSYLVIO_007498	OG7
C4B63_84g79 conserved hypothetical protein	—	OG6 TCSYLVIO_004844 ↔ TCSYLVIO_005046 OG7 TCSYLVIO_004844 ↔ TCSYLVIO_005046	Both
C4B63_120g42 ⚠ Pseudouridylate synthase 7 homolog	—	OG6 TCSYLVIO_001604 ↔ TCSYLVIO_005046 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_005046	Both
C4B63_12g257 ⚠ Pseudouridylate synthase 7 homolog	—	OG6 TCSYLVIO_001604 ↔ TCSYLVIO_005046 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_005046	Both
C4B63_8g543 small GTP-binding protein	—	OG6 TCSYLVIO_002378 ↔ TCSYLVIO_005046 OG7 TCSYLVIO_002378 ↔ TCSYLVIO_005046	Both
C4B63_32g333 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005046 ↔ TCSYLVIO_007498 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_007498	Both
C4B63_51g197 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_002175 ↔ TCSYLVIO_005046 OG7 TCSYLVIO_002175 ↔ TCSYLVIO_005046	Both
C4B63_25g114 conserved hypothetical protein	—	OG6 TCSYLVIO_005046 ↔ TCSYLVIO_009032 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_009032	Both
C4B63_76g132 ⚠ 50S ribosomal protein L22	—	OG6 Tb927.10.7380 ↔ Tb927.7.2760 OG7 Tb927.10.7380 ↔ Tb927.7.2760	Both
C4B63_12g256 ⚠ conserved hypothetical protein	—	OG6 Tb927.10.7380 ↔ Tb927.11.6000 OG7 Tb927.10.7380 ↔ Tb927.11.6000	Both
C4B63_19g248 ⚠ Mitochondrial SSU ribosomal protein	—	OG6 Tb927.10.7380 ↔ Tb927.11.1250 OG7 Tb927.10.7380 ↔ Tb927.11.1250	Both

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