C4B63_442g1

ATP-dependent DEAD/H RNA helicase

Trypanosoma cruzi Dm28c 2018 OG6: OG6_158005 OG7: OG7_0052329 63 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 63 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_19g35 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005482 ↔ TCSYLVIO_006554 OG6 Tb927.11.12930 ↔ Tb927.11.1630 OG7 TCSYLVIO_005482 ↔ TCSYLVIO_006554 OG7 Tb927.11.12930 ↔ Tb927.11.1630	Both
C4B63_57g103 ⚠ conserved hypothetical protein	—	OG6 Tb927.10.7380 ↔ Tb927.11.12930 OG6 TCSYLVIO_005046 ↔ TCSYLVIO_006554 OG7 Tb927.10.7380 ↔ Tb927.11.12930 OG7 TCSYLVIO_005046 ↔ TCSYLVIO_006554	Both
C4B63_120g42 ⚠ Pseudouridylate synthase 7 homolog	—	OG6 Tb927.11.12930 ↔ Tb927.11.5990 OG6 TCSYLVIO_001604 ↔ TCSYLVIO_006554 OG7 Tb927.11.12930 ↔ Tb927.11.5990 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_006554	Both
C4B63_49g55 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.12930 ↔ Tb927.7.3460 OG6 TCSYLVIO_001807 ↔ TCSYLVIO_006554 OG7 TCSYLVIO_001807 ↔ TCSYLVIO_006554 OG7 Tb927.11.12930 ↔ Tb927.7.3460	Both
C4B63_51g196 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.12930 ↔ Tb927.11.4650 OG6 TCSYLVIO_002175 ↔ TCSYLVIO_006554 OG7 Tb927.11.12930 ↔ Tb927.11.4650 OG7 TCSYLVIO_002175 ↔ TCSYLVIO_006554	Both
C4B63_25g114 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.12930 ↔ Tb927.5.2070 OG6 TCSYLVIO_006554 ↔ TCSYLVIO_009032 OG7 Tb927.11.12930 ↔ Tb927.5.2070 OG7 TCSYLVIO_006554 ↔ TCSYLVIO_009032	Both
C4B63_8g543 ⚠ small GTP-binding protein	—	OG6 Tb927.11.12930 ↔ Tb927.7.1640 OG6 TCSYLVIO_002378 ↔ TCSYLVIO_006554 OG7 Tb927.11.12930 ↔ Tb927.7.1640 OG7 TCSYLVIO_002378 ↔ TCSYLVIO_006554	Both
C4B63_12g257 ⚠ Pseudouridylate synthase 7 homolog	—	OG6 Tb927.11.12930 ↔ Tb927.11.5990 OG6 TCSYLVIO_001604 ↔ TCSYLVIO_006554 OG7 Tb927.11.12930 ↔ Tb927.11.5990 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_006554	Both
C4B63_51g197 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.12930 ↔ Tb927.11.4650 OG6 TCSYLVIO_002175 ↔ TCSYLVIO_006554 OG7 Tb927.11.12930 ↔ Tb927.11.4650 OG7 TCSYLVIO_002175 ↔ TCSYLVIO_006554	Both
C4B63_293g3 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.12930 ↔ Tb927.7.3460 OG6 TCSYLVIO_001807 ↔ TCSYLVIO_006554 OG7 TCSYLVIO_001807 ↔ TCSYLVIO_006554 OG7 Tb927.11.12930 ↔ Tb927.7.3460	Both
C4B63_84g79 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004844 ↔ TCSYLVIO_006554 OG7 TCSYLVIO_004844 ↔ TCSYLVIO_006554	Both
C4B63_10g521 ⚠ mitochondrial ribosomal protein L3	—	OG6 TCSYLVIO_006554 ↔ TCSYLVIO_010727 OG7 TCSYLVIO_006554 ↔ TCSYLVIO_010727	Both
C4B63_32g333 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_006554 ↔ TCSYLVIO_007498 OG7 TCSYLVIO_006554 ↔ TCSYLVIO_007498	Both
C4B63_72g100 ⚠ MRPL47	—	OG6 TCSYLVIO_006554 ↔ TCSYLVIO_007130 OG7 TCSYLVIO_006554 ↔ TCSYLVIO_007130	Both
C4B63_72g90 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_006554 ↔ TCSYLVIO_007121 OG7 TCSYLVIO_006554 ↔ TCSYLVIO_007121	Both
C4B63_72g89 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_006554 ↔ TCSYLVIO_007121 OG7 TCSYLVIO_006554 ↔ TCSYLVIO_007121	Both
C4B63_35g186 ⚠ 50S ribosomal protein L17	—	OG6 TCSYLVIO_006554 ↔ TCSYLVIO_007654 OG7 TCSYLVIO_006554 ↔ TCSYLVIO_007654	Both
C4B63_43g147 ⚠ mitochondrial RNA binding complex 1 subunit	—	OG6 TCSYLVIO_006554 ↔ TCSYLVIO_009360 OG7 TCSYLVIO_006554 ↔ TCSYLVIO_009360	Both
C4B63_72g88 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_006554 ↔ TCSYLVIO_007121 OG7 TCSYLVIO_006554 ↔ TCSYLVIO_007121	Both
C4B63_340g8 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_006554 ↔ TCSYLVIO_007498 OG7 TCSYLVIO_006554 ↔ TCSYLVIO_007498	Both
C4B63_31g78 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_006554 ↔ TCSYLVIO_010544 OG7 TCSYLVIO_006554 ↔ TCSYLVIO_010544	Both
C4B63_31g116 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_006554 ↔ TCSYLVIO_010573 OG7 TCSYLVIO_006554 ↔ TCSYLVIO_010573	Both
C4B63_72g91 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_006554 ↔ TCSYLVIO_007121 OG7 TCSYLVIO_006554 ↔ TCSYLVIO_007121	Both
C4B63_16g110 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_000178 ↔ TCSYLVIO_006554 OG7 TCSYLVIO_000178 ↔ TCSYLVIO_006554	Both
C4B63_9g446 ⚠ Probable methyltransferase TARBP1	—	OG7 TCSYLVIO_006554 ↔ TCSYLVIO_007498	OG7
C4B63_30g181 ⚠ rRNA methyltransferase 1, mitochondrial	—	OG7 TCSYLVIO_006554 ↔ TCSYLVIO_007498	OG7
C4B63_83g24 ⚠ zinc-finger (CCCH type) protein	—	OG7 TCSYLVIO_003384 ↔ TCSYLVIO_006554	OG7
C4B63_397g11 ⚠ zinc-finger CCCH domain containing protein 11	—	OG7 TCSYLVIO_003384 ↔ TCSYLVIO_006554	OG7
C4B63_12g2035c ⚠ zinc-finger protein 2	—	OG7 TCSYLVIO_003384 ↔ TCSYLVIO_006554	OG7
C4B63_15g5 ⚠ zinc-finger CCCH domain containing protein 11	—	OG7 TCSYLVIO_003384 ↔ TCSYLVIO_006554	OG7
C4B63_128g63 ⚠ GTP-binding protein	—	OG7 TCSYLVIO_005645 ↔ TCSYLVIO_006554	OG7
C4B63_56g32 ⚠ GTPase	—	OG7 TCSYLVIO_005645 ↔ TCSYLVIO_006554	OG7
C4B63_8g202 ⚠ GTP-binding protein	—	OG7 TCSYLVIO_005645 ↔ TCSYLVIO_006554	OG7
C4B63_91g35 ⚠ GTPase	—	OG7 TCSYLVIO_005645 ↔ TCSYLVIO_006554	OG7
C4B63_128g62 ⚠ 50S ribosome-binding GTPase	—	OG7 TCSYLVIO_005645 ↔ TCSYLVIO_006554	OG7
C4B63_128g61 ⚠ 50S ribosome-binding GTPase	—	OG7 TCSYLVIO_005645 ↔ TCSYLVIO_006554	OG7
C4B63_2g431 ⚠ GTPase protein	—	OG7 TCSYLVIO_005645 ↔ TCSYLVIO_006554	OG7
C4B63_4g456 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_006046 ↔ TCSYLVIO_006554 OG7 TCSYLVIO_006046 ↔ TCSYLVIO_006554	Both
C4B63_18g169 ⚠ Zinc finger CCCH domain-containing protein 47	—	OG6 TCSYLVIO_003384 ↔ TCSYLVIO_006554 OG7 TCSYLVIO_003384 ↔ TCSYLVIO_006554	Both
C4B63_42g77 ⚠ heat shock protein	—	OG6 TCSYLVIO_003164 ↔ TCSYLVIO_006554 OG7 TCSYLVIO_003164 ↔ TCSYLVIO_006554	Both
C4B63_56g64 ⚠ Present in the outer mitochondrial membrane p	—	OG6 TCSYLVIO_003157 ↔ TCSYLVIO_006554 OG7 TCSYLVIO_003157 ↔ TCSYLVIO_006554	Both
C4B63_42g67 ⚠ Protein F37C4.5	—	OG6 TCSYLVIO_003157 ↔ TCSYLVIO_006554 OG7 TCSYLVIO_003157 ↔ TCSYLVIO_006554	Both
C4B63_243g4 ⚠ Present in the outer mitochondrial membrane p	—	OG6 TCSYLVIO_003157 ↔ TCSYLVIO_006554 OG7 TCSYLVIO_003157 ↔ TCSYLVIO_006554	Both
C4B63_148g32 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.12930 ↔ Tb927.11.14980 OG7 Tb927.11.12930 ↔ Tb927.11.14980	Both
C4B63_7g348 ⚠ ribosomal protein L13	—	OG6 Tb927.11.12930 ↔ Tb927.4.1070 OG7 Tb927.11.12930 ↔ Tb927.4.1070	Both
C4B63_18g251 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.12930 ↔ Tb927.6.4080 OG7 Tb927.11.12930 ↔ Tb927.6.4080	Both
C4B63_17g241 ⚠ conserved hypothetical protein	—	OG6 Tb927.11.12930 ↔ Tb927.11.14980 OG7 Tb927.11.12930 ↔ Tb927.11.14980	Both
C4B63_2g805 ⚠ SpoU rRNA Methylase family	—	OG6 Tb927.11.12930 ↔ Tb927.9.12850 OG7 Tb927.11.12930 ↔ Tb927.9.12850	Both
C4B63_2g345 ⚠ GTP-binding protein	—	OG6 TCSYLVIO_005645 ↔ TCSYLVIO_006554 OG7 TCSYLVIO_005645 ↔ TCSYLVIO_006554	Both
C4B63_304g15 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_006046 ↔ TCSYLVIO_006554 OG7 TCSYLVIO_006046 ↔ TCSYLVIO_006554	Both

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