C4B63_72g80

cAMP-specific phosphodiesterase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_146459 OG7: OG7_0042785 111 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 111 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_233g31 ⚠
ubiquitin hydrolase
— OG7
C4B63_233g32 ⚠
ubiquitin hydrolase
— OG7
C4B63_2g4 ⚠
ubiquitin hydrolase
— OG7
C4B63_26g231 ⚠
ubiquitin hydrolase(fragment)
— Both
C4B63_26g232 ⚠
ubiquitin hydrolase(fragment)
— Both
C4B63_7g391 ⚠
ubiquitin hydrolase
— Both
C4B63_7g392 ⚠
ubiquitin hydrolase
— Both
C4B63_85g46 ⚠
Ring finger domain/Zn-finger in ubiquitin-hyd
— Both
C4B63_2g448 ⚠
Unc104-like kinesin
— OG6
C4B63_9g378 ⚠
conserved hypothetical protein
— Both
C4B63_9g382 ⚠
conserved hypothetical protein
— Both
C4B63_295g26 ⚠
glutamate dehydrogenase
— Both
C4B63_18g263 ⚠
SPA/DENN domain containing protein
— Both
C4B63_49g160 ⚠
ATP-dependent DEAD/H RNA helicase
— OG6
C4B63_47g47 ⚠
U3 small nucleolar RNA-interacting protein 2
— Both
C4B63_138g26 ⚠
translation-associated element 2
— Both
C4B63_83g72 ⚠
replication Factor A 28 kDa subunit
— Both
C4B63_23g76 ⚠
ubiquitin carboxyl-terminal hydrolase
— Both
C4B63_25g232 ⚠
Tetratricopeptide repeat protein 27 homolog
— Both
C4B63_18g153 ⚠
T-complex protein 11
— Both
C4B63_16g331 ⚠
ubiquitin-activating enzyme E1
— Both
C4B63_2g786 ⚠
ubiquitin-activating enzyme E1
— Both
C4B63_160g33 ⚠
ubiquitin-activating enzyme E1
— Both
C4B63_18g260 ⚠
small glutamine-rich tetratricopeptide repeat
— OG6
C4B63_56g67 ⚠
Sperm-tail PG-rich repeat-containing protein
— Both
C4B63_243g7 ⚠
conserved hypothetical protein
— Both
C4B63_12g179 ⚠
anion-transporting ATPase-like
— Both
C4B63_212g12 ⚠
anion-transporting ATPase-like
— Both
C4B63_323g12 ⚠
protein kinase
— OG6
C4B63_23g3 ⚠
protein kinase
— OG6
C4B63_156g10 ⚠
protein kinase
— OG6
C4B63_79g39 ⚠
conserved hypothetical protein
— OG7
C4B63_10g489 ⚠
ADP-ribosylation factor GTPase activating pro
— OG7
C4B63_6g417 ⚠
ADP-ribosylation factor GTPase activating pro
— OG7
C4B63_75g70 ⚠
ADP-ribosylation factor GTPase activating pro
— OG7
C4B63_17g265 ⚠
Probable ADP-ribosylation factor GTPase-activ
— OG7
C4B63_7g290 ⚠
RING finger protein ETP1
— OG7
C4B63_6g582 ⚠
conserved hypothetical protein
— OG7
C4B63_61g132 ⚠
WD domain, G-beta repeat
— OG7
C4B63_17g55 ⚠
cyclin 9
— OG7
C4B63_61g104 ⚠
conserved hypothetical protein
— OG7
C4B63_1g63 ⚠
SKP1
— OG7
C4B63_24g227 ⚠
conserved hypothetical protein
— OG7
C4B63_28g87 ⚠
ubiquitin carboxyl-terminal hydrolase
— OG7
C4B63_6g205 ⚠
Mitochondrial import receptor subunit ATOM69
— Both
C4B63_58g121 ⚠
ubiquitin hydrolase(fragment)
— OG7
C4B63_14g40 ⚠
conserved hypothetical protein
— OG7
C4B63_42g42 ⚠
co-chaperone GrpE
— Both
C4B63_42g96 ⚠
ubiquitin hydrolase
— OG7
C4B63_230g12 ⚠
Mitochondrial import receptor subunit ATOM69
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.