LAEL147_000743400

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative

Leishmania aethiopica L147 OG6: OG6_146732 OG7: OG7_0002830 155 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 155 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LAEL147_000285000 ⚠ phenylalanyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_005548 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_240010.1	OG7
LAEL147_000164700 ⚠ cysteinyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_240010.1	OG7
LAEL147_000540600 ⚠ aspartyl aminopeptidase, putative	—	OG7 LdBPK_240010.1 ↔ LdBPK_292470.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004406	OG7
LAEL147_000373600 ⚠ pyruvate dehydrogenase (lipoamide) kinase, pu	—	OG7 Tb927.1.1000 ↔ Tb927.11.4780 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007262	OG7
LAEL147_000295600 ⚠ developmentally regulated phosphoprotein-like	—	OG7 Tb927.1.1000 ↔ Tb927.11.4780 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007262	OG7
LAEL147_000358000 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
LAEL147_000878700 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
LAEL147_000773700 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
LAEL147_000396000 ⚠ tubulin folding cofactor D, putative	—	OG7 LdBPK_240010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_007262	OG7
LAEL147_000322800 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
LAEL147_000551200 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
LAEL147_000725600 ⚠ asparaginyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
LAEL147_000026000 ⚠ ubiquitin activating enzyme, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010542 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010542	OG7
LAEL147_000761500 ⚠ NADH-dependent fumarate reductase, putative	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
LAEL147_000757700 ⚠ NADH-dependent fumarate reductase, putative	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
LAEL147_000761400 ⚠ NADH-dependent fumarate reductase, putative	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
LAEL147_000096500 ⚠ flavoprotein subunit-like protein	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
LAEL147_000468700 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_005512 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005512	OG7
LAEL147_000284300 ⚠ peptidyl-prolyl cis-trans isomerase, macropha	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005957	OG7
LAEL147_000417900 ⚠ Leucine-rich repeat, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006116	OG7
LAEL147_000210500 ⚠ ribonucleoprotein p18, mitochondrial precurso	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_002426 OG7 TCSYLVIO_002426 ↔ TCSYLVIO_007262	OG7
LAEL147_000613000 ⚠ uridine kinase-like protein	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003952	OG7
LAEL147_000140400 ⚠ FKBP-type peptidyl-prolyl cis-trans isomerase	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005957	OG7
LAEL147_000172200 ⚠ arginine N-methyltransferase-like protein	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006901	OG7
LAEL147_000522500 ⚠ heat shock protein 90, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009400 +2 more	OG7
LAEL147_000434600 ⚠ heat shock 70 protein-like protein	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005689	OG7
LAEL147_000333100 ⚠ ATP synthase F1 subunit gamma protein, putati	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009375 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009375	OG7
LAEL147_000144300 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003586 OG7 TCSYLVIO_003586 ↔ TCSYLVIO_007262	OG7
LAEL147_000081700 ⚠ arginine N-methyltransferase, type III, putat	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006901	OG7
LAEL147_000351600 ⚠ GDP-mannose pyrophosphorylase	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007603	OG7
LAEL147_000622600 ⚠ U2 small nuclear ribonucleoprotein 40K, putat	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006116	OG7
LAEL147_000717000 ⚠ inositol 5-phosphatase-like protein	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007569	OG7
LAEL147_000133600 ⚠ Exonuclease, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010944	OG7
LAEL147_000511600 ⚠ heat-shock protein hsp70, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005689	OG7
LAEL147_000354000 ⚠ pteridine reductase 1	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008848 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008848	OG7
LAEL147_000692300 ⚠ heat shock protein, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009400 +2 more	OG7
LAEL147_000668200 ⚠ heat shock protein 83-17	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009400 +2 more	OG7
LAEL147_000528100 ⚠ Hsp70 protein/TPR repeat, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005957	OG7
LAEL147_000514600 ⚠ transcription factor-like protein	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010728 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010728	OG7
LAEL147_000382000 ⚠ inositol polyphosphate phosphatase, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007569	OG7
LAEL147_000090300 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006116	OG7
LAEL147_000494700 ⚠ heat-shock protein hsp70, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005689	OG7
LAEL147_000870000 ⚠ beta-adaptin protein, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004597 OG7 TCSYLVIO_004597 ↔ TCSYLVIO_007262	OG7
LAEL147_000745600 ⚠ GRIP domain containing protein, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003707 OG7 TCSYLVIO_003707 ↔ TCSYLVIO_007262	OG7
LAEL147_000491500 ⚠ oxidoreductase-like protein	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_002566	OG7
LAEL147_000078200 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_001826	OG7
LAEL147_000347400 ⚠ fk506-binding protein 1-like protein	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005957	OG7
LAEL147_000158800 ⚠ protein transport protein SEC31, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_001623	OG7
LAEL147_000037000 ⚠ Leucine Rich repeats (2 copies), putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006116	OG7
LAEL147_000041700 ⚠ arginine N-methyltransferase, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006901	OG7

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