LAMA_000592700

Phosphatidylinositol-specific phospholipase C, X domain/PDZ domain containing protein, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_146793 OG7: OG7_0037550 176 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 176 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000595400 ⚠
HECT-domain (ubiquitin-transferase), putative
— OG7
LAMA_000434400
hypothetical protein, conserved
— Both
LAMA_000249200
Transaldolase/Fructose-6-phosphate aldolase,
— Both
LAMA_000055500
Tetratricopeptide repeat, putative
— Both
LAMA_000050100 ⚠
MORN repeat, putative
— Both
LAMA_000063900
Fip1 motif/Zinc finger C-x8-C-x5-C-x3-H type
— Both
LAMA_000388600 ⚠
FAT domain/Phosphatidylinositol 3- and 4-kina
— Both
LAMA_000433700
CAF1 family ribonuclease, putative
— Both
LAMA_000057000
Axonemal dynein light chain, putative
— Both
LAMA_000296300 ⚠
hypothetical protein
— OG6
LAMA_000024000 ⚠
Kinesin motor domain/Microtubule binding, put
— OG6
LAMA_000296100 ⚠
hypothetical protein
— OG6
LAMA_000296400 ⚠
hypothetical protein, conserved
— OG6
LAMA_000566800 ⚠
haloacid dehalogenase-like hydrolase/Sucrose-
— Both
LAMA_000457300 ⚠
Aminotransferase class I and II, putative
— Both
LAMA_000775400 ⚠
Aminotransferase class I and II, putative
— Both
LAMA_000586100
MATH domain containing protein, putative
— Both
LAMA_000566200
WD domain, G-beta repeat, putative
— Both
LAMA_000453000
Alanine racemase, N-terminal domain containin
— Both
LAMA_000566500
Electron transfer flavoprotein domain/Electro
— Both
LAMA_000420700
SEP domain containing protein, putative
— Both
LAMA_000575600
Telomere recombination/Putative GTP-binding c
— Both
LAMA_000085800
hypothetical protein, conserved
— Both
LAMA_000189900 ⚠
Tetratricopeptide repeat, putative
— Both
LAMA_000624300
Ubiquitin family/Ubiquitin carboxyl-terminal
— Both
LAMA_000607500
GYF domain 2/DnaJ domain containing protein,
— Both
LAMA_000656800
hypothetical protein, conserved
— Both
LAMA_000315800
WD domain, G-beta repeat, putative
— Both
LAMA_000653500
hypothetical protein, conserved
— Both
LAMA_000667900
Mono-functional DNA-alkylating methyl methane
— Both
LAMA_000593000
Tetratricopeptide repeat, putative
— Both
LAMA_000657400
hypothetical protein, conserved
— Both
LAMA_000284100
Protein tyrosine kinase/Protein kinase domain
— OG6
LAMA_000370200 ⚠
Concanavalin A-like lectin/glucanases superfa
— Both
LAMA_000724400 ⚠
Transcription factor S-II (TFIIS), putative
— Both
LAMA_000153100
ATPase family associated with various cellula
— Both
LAMA_000194900 ⚠
Kinesin motor domain/Microtubule binding/TRAF
— OG7
LAMA_000209000 ⚠
Kinesin motor domain/Microtubule binding, put
— OG7
LAMA_000026100 ⚠
Kinesin motor domain/Microtubule binding, put
— OG7
LAMA_000626000 ⚠
Microtubule binding/Kinesin motor domain cont
— OG7
LAMA_000073300 ⚠
MORN repeat, putative
— OG7
LAMA_000747800 ⚠
Guanine nucleotide exchange factor in Golgi t
— OG7
LAMA_000749000 ⚠
Guanine nucleotide exchange factor in Golgi t
— OG7
LAMA_000597100 ⚠
WW domain containing protein, putative
— OG7
LAMA_000488700 ⚠
NAD binding domain of 6-phosphogluconate dehy
— OG7
LAMA_000396800 ⚠
Protein tyrosine kinase/Protein kinase domain
— OG7
LAMA_000087800 ⚠
Adaptin N terminal region containing protein,
— OG7
LAMA_000420600 ⚠
Choline/Carnitine o-acyltransferase, putative
— OG7
LAMA_000065800 ⚠
RecF/RecN/SMC N terminal domain/AAA domain/SM
— OG7
LAMA_000801800 ⚠
AAA ATPase domain/RecF/RecN/SMC N terminal do
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.