LAMA_000694100

SPRY domain/HECT-domain (ubiquitin-transferase), putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_147203 OG7: OG7_0031172 92 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 92 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000300200
PCI domain containing protein, putative
— Both
LAMA_000742500 ⚠
N-terminal region of Chorein or VPS13/Vacuola
— OG7
LAMA_000257100
WD domain, G-beta repeat, putative
— OG7
LAMA_000605100
hypothetical protein, conserved
— Both
LAMA_000153100
ATPase family associated with various cellula
— Both
LAMA_000675800
RNA recognition motif. (a.k.a. RRM, RBD, or R
— Both
LAMA_000350900
Proteasomal ATPase OB C-terminal domain/Holli
— OG6
LAMA_000463100
hypothetical protein, conserved
— Both
LAMA_000189900 ⚠
Tetratricopeptide repeat, putative
— Both
LAMA_000099300
von Willebrand factor type A domain/Ubiquitin
— Both
LAMA_000236700 ⚠
hypothetical protein, conserved
— Both
LAMA_000266500
Microtubule binding/Kinesin motor domain cont
— OG6
LAMA_000509400 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LAMA_000127500
RPN1/RPN2 N-terminal domain/Proteasome/cyclos
— Both
LAMA_000197500 ⚠
DEAD/DEAH box helicase/Type III restriction e
— Both
LAMA_000185900
Proteasomal ATPase OB C-terminal domain/AAA d
— OG6
LAMA_000267800 ⚠
N-terminal helicase PWI domain/DEAD/DEAH box
— Both
LAMA_000806000
PRO8NT (NUC069), PrP8 N-terminal domain/PROCN
— Both
LAMA_000403400
PCI domain/26S proteasome regulatory subunit
— Both
LAMA_000697700
WD domain, G-beta repeat, putative
— Both
LAMA_000020200
PCI domain/Proteasome regulatory subunit C-te
— Both
LAMA_000683300
26S proteasome subunit RPN7/PCI domain contai
— Both
LAMA_000658200
JAB1/Mov34/MPN/PAD-1 ubiquitin protease/Maint
— Both
LAMA_000696200 ⚠
Ankyrin repeats (3 copies)/Ankyrin repeats (m
— OG7
LAMA_000668200 ⚠
DEAD/DEAH box helicase/Type III restriction e
— OG7
LAMA_000768000 ⚠
Cyclic nucleotide-binding domain containing p
— OG7
LAMA_000450700 ⚠
DEAD/DEAH box helicase/Helicase conserved C-t
— OG7
LAMA_000195200 ⚠
Cyclic nucleotide-binding domain containing p
— OG7
LAMA_000694500 ⚠
Cyclic nucleotide-binding domain containing p
— OG7
LAMA_000752000 ⚠
Cyclic nucleotide-binding domain containing p
— OG7
LAMA_000390000 ⚠
Raptor N-terminal CASPase like domain contain
— OG7
LAMA_000757200 ⚠
Metallo-beta-lactamase superfamily/Metallo-be
— OG7
LAMA_000043100 ⚠
FYVE zinc finger containing protein, putative
— OG7
LAMA_000116800 ⚠
Ankyrin repeats (3 copies)/Ankyrin repeats (m
— OG7
LAMA_000055200 ⚠
Ankyrin repeats (3 copies)/Ankyrin repeats (m
— OG7
LAMA_000607500
GYF domain 2/DnaJ domain containing protein,
— Both
LAMA_000793100 ⚠
Ankyrin repeats (3 copies)/Ankyrin repeats (m
— OG7
LAMA_000044900 ⚠
Ankyrin repeats (3 copies)/Ankyrin repeats (m
— OG7
LAMA_000766400 ⚠
Ankyrin repeats (many copies)/Ankyrin repeats
— OG7
LAMA_000055100 ⚠
Ankyrin repeat/DHHC palmitoyltransferase, put
— OG7
LAMA_000618200 ⚠
Ankyrin repeats (3 copies)/Ankyrin repeat/Ank
— OG7
LAMA_000649300 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LAMA_000332000 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LAMA_000347700 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LAMA_000744000 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LAMA_000174600 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LAMA_000474100
hypothetical protein, conserved
— Both
LAMA_000218100
Kinesin motor domain/Microtubule binding, put
— OG6
LAMA_000179800
hypothetical protein, conserved
— Both
LAMA_000735800
JAB1/Mov34/MPN/PAD-1 ubiquitin protease/Proka
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.