LPAL13_170007500

cystathionine beta-synthase
Leishmania panamensis MHOM/COL/81/L13 OG6: OG6_100154 OG7: OG7_0002172 86 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 86 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LPAL13_230011600 ⚠
AMP-binding enzyme/AMP-binding enzyme C-termi
— +1 more Both
LPAL13_230011500 ⚠
acetyl-CoA synthetase, putative
— +1 more Both
LPAL13_000018900 ⚠
AMP-binding enzyme/AMP-binding enzyme C-termi
— +1 more Both
LPAL13_260012800 ⚠
aspartate--ammonia ligase, putative
— Both
LPAL13_270026700 ⚠
trypanothione synthetase, putative
— Both
LPAL13_000016500 ⚠
AMP-binding enzyme, putative
— +1 more Both
LPAL13_260024300 ⚠
Methyltransferase domain containing protein,
— OG7
LPAL13_330035200 ⚠
mitochondrial processing peptidase alpha subu
— Both
LPAL13_210008300 ⚠
mitochondrial processing peptidase alpha subu
— OG7
LPAL13_130011900 ⚠
mitochondrial processing peptidase alpha subu
— OG7
LPAL13_090013900 ⚠
Uncharacterised protein family (UPF0160), put
— OG6
LPAL13_140008600 ⚠
threonine synthase, putative
— Both
LPAL13_350078100 ⚠
2,3-bisphosphoglycerate-independent phosphogl
— Both
LPAL13_290024900 ⚠
aminopeptidase, putative
— Both
LPAL13_230015100 ⚠
3-ketoacyl-CoA thiolase, putative
— Both
LPAL13_220015100 ⚠
ribonucleoside-diphosphate reductase small ch
— Both
LPAL13_200054700 ⚠
cytidine triphosphate synthase, putative
— Both
LPAL13_270028600 ⚠
branched-chain amino acid aminotransferase, p
— Both
LPAL13_300018000 ⚠
pyridoxal kinase, putative
— Both
LPAL13_040011700 ⚠
spermidine synthase
— Both
LPAL13_270028800 ⚠
ribonucleoside-diphosphate reductase small ch
— Both
LPAL13_280037000 ⚠
cytosolic malate dehydrogenase
— Both
LPAL13_290031300 ⚠
inosine-adenosine-guanosine-nucleoside hydrol
— Both
LPAL13_240028100 ⚠
3-hydroxy-3-methylglutaryl-CoA synthase, puta
— Both
LPAL13_270015500
WD40 repeats, putative
— OG7
LPAL13_250027100 ⚠
glutathionylspermidine synthase, putative
— OG7
LPAL13_300041500 ⚠
Protein of unknown function (DUF3808)/Tetratr
— Both
LPAL13_350053900 ⚠
mitochondrial intermediate peptidase, putativ
— OG7
LPAL13_330037600 ⚠
D-alanyl-glycyl endopeptidase-like protein
— OG7
LPAL13_120014300 ⚠
puromycin-sensitive aminopeptidase-like prote
— OG7
LPAL13_260007800 ⚠
aminopeptidase-like protein
— OG7
LPAL13_230010400 ⚠
trypanothione synthetase, putative
— OG7
LPAL13_330037500 ⚠
D-alanyl-glycyl endopeptidase-like protein
— OG7
LPAL13_200040900 ⚠
serine palmitoyltransferase-like protein
— OG7
LPAL13_250027300 ⚠
hypothetical protein
— OG7
LPAL13_150007800 ⚠
sterol carrier protein, putative
— OG7
LPAL13_310006900 ⚠
nucleolar protein, putative
— OG7
LPAL13_250027200 ⚠
hypothetical protein
— OG7
LPAL13_340008100 ⚠
serine palmitoyltransferase, putative
— OG7
LPAL13_150016400 ⚠
protein kinase, putative
— OG7
LPAL13_200031200 ⚠
regulatory subunit of protein kinase a-like p
— OG7
LPAL13_200021000 ⚠
Protein of unknown function (DUF3808), putati
— OG7
LPAL13_280025000 ⚠
NOL1/NOP2/sun family, putative
— OG7
LPAL13_250012000 ⚠
PUA domain/NOL1/NOP2/sun family, putative
— OG7
LPAL13_290022400 ⚠
NOL1/NOP2/sun family, putative
— OG7
LPAL13_320048300 ⚠
cAMP response protein, putative
— OG7
LPAL13_230020000 ⚠
hypothetical protein, conserved
— Both
LPAL13_350030700 ⚠
tyrosine aminotransferase
— Both
LPAL13_300011600 ⚠
nitrate reductase, putative
— OG6
LPAL13_190020300 ⚠
mitogen activated protein kinase 4, putative
— OG6
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.