LTRL590_030006800

delta-1-pyrroline-5-carboxylate dehydrogenase, putative

Leishmania tropica L590 OG6: OG6_102275 OG7: OG7_0000710 41 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 41 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LTRL590_110013100 3-methylcrotonoyl-CoA carboxylase beta subuni	—	OG6 Tb927.10.3210 ↔ Tb927.11.6630 OG7 Tb927.10.3210 ↔ Tb927.11.6630	Both
LTRL590_080014700 ⚠ phosphoribosylpyrophosphate synthetase	—	OG6 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 OG7 Tb927.10.3210 ↔ Tb927.11.3030 +1 more	Both
LTRL590_350005500 2-oxoisovalerate dehydrogenase beta subunit,	—	OG6 Tb927.10.3210 ↔ Tb927.10.4330 OG7 Tb927.10.3210 ↔ Tb927.10.4330	Both
LTRL590_230005400 ⚠ peroxidoxin	—	OG6 Tb927.10.3210 ↔ Tb927.8.1990 OG7 Tb927.10.3210 ↔ Tb927.8.1990	Both
LTRL590_310043700 ⚠ Carbamoyl-phosphate synthase L chain, N-termi	—	OG6 Tb927.10.3210 ↔ Tb927.8.7100 OG7 Tb927.10.3210 ↔ Tb927.8.7100	Both
LTRL590_360065700 ⚠ phosphoribosylpyrophosphate synthetase, putat	—	OG6 Tb927.10.3210 ↔ Tb927.10.9430 OG6 Tb927.10.3210 ↔ Tb927.11.3030 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 +2 more	Both
LTRL590_230009000 (H+)-ATPase G subunit, putative	—	OG6 Tb927.10.3210 ↔ Tb927.8.2310 OG7 Tb927.10.3210 ↔ Tb927.8.2310	Both
LTRL590_150017000 ⚠ tryparedoxin peroxidase	—	OG6 Tb927.10.3210 ↔ Tb927.8.1990 OG7 Tb927.10.3210 ↔ Tb927.8.1990	Both
LTRL590_260022000 cytochrome c oxidase subunit V, putative	—	OG6 Tb927.10.3210 ↔ Tb927.9.3170 OG7 Tb927.10.3210 ↔ Tb927.9.3170	Both
LTRL590_360049400 S-adenosylhomocysteine hydrolase	—	OG6 Tb927.10.3210 ↔ Tb927.11.9590 OG7 Tb927.10.3210 ↔ Tb927.11.9590	Both
LTRL590_330026700 ⚠ phosphoribosylpyrophosphate synthetase, putat	—	OG6 Tb927.10.3210 ↔ Tb927.10.9430 OG6 Tb927.10.3210 ↔ Tb927.11.3030 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 +2 more	Both
LTRL590_350011700 vacuolar ATP synthase subunit d, putative	—	OG6 Tb927.10.3210 ↔ Tb927.10.3760 OG7 Tb927.10.3210 ↔ Tb927.10.3760	Both
LTRL590_220010900 Uncharacterised protein family UPF0066, putat	—	OG6 TCSYLVIO_001255 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_001255 ↔ TCSYLVIO_004515	Both
LTRL590_120010900 vacuolar ATP synthase subunit, putative	—	OG6 Tb927.1.3820 ↔ Tb927.10.3210 OG7 Tb927.1.3820 ↔ Tb927.10.3210	Both
LTRL590_210007900 ⚠ hexokinase, putative	—	OG6 Tb927.10.2010 ↔ Tb927.10.3210 OG6 Tb927.10.2020 ↔ Tb927.10.3210 OG7 Tb927.10.2010 ↔ Tb927.10.3210 OG7 Tb927.10.2020 ↔ Tb927.10.3210	Both
LTRL590_210008000 ⚠ Hexokinase, putative	—	OG6 Tb927.10.2010 ↔ Tb927.10.3210 OG6 Tb927.10.2020 ↔ Tb927.10.3210 OG7 Tb927.10.2010 ↔ Tb927.10.3210 OG7 Tb927.10.2020 ↔ Tb927.10.3210	Both
LTRL590_010014100 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	OG7
LTRL590_360081200 ⚠ prolyl oligopeptidase, putative	—	OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	OG7
LTRL590_010014200 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	OG7
LTRL590_010013900 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	OG7
LTRL590_010013800 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	OG7
LTRL590_130015300 leucyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003028 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_003028 ↔ TCSYLVIO_004515	Both
LTRL590_060008500 ⚠ serine peptidase, clan SC, family S9A-like pr	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_006546 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	Both
LTRL590_340008500 ⚠ deoxyhypusine synthase	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_007258	Both
LTRL590_360048700 glycyl tRNA synthetase, putative	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_009222 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_009222	Both
LTRL590_350038700 Peroxin 19	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_005818 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_005818	Both
LTRL590_090013200 ⚠ oligopeptidase b	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_006546 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	Both
LTRL590_350013900 hypothetical protein, conserved	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_005125 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_005125	Both
LTRL590_200007700 ⚠ deoxyhypusine synthase, putative	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_007258	Both
LTRL590_300039000 valyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003345 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_003345 ↔ TCSYLVIO_004515	Both
LTRL590_310045200 phosphoglycan beta 1,3 galactosyltransferase	—	OG6 TCSYLVIO_002764 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_002764 ↔ TCSYLVIO_004515	Both
LTRL590_350008600 hypothetical protein, conserved	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_005080 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_005080	Both
LTRL590_300035600 T-complex protein 11, putative	—	OG6 TCSYLVIO_003373 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_003373 ↔ TCSYLVIO_004515	Both
LTRL590_290033600 serine/threonine-protein kinase, putative	—	OG6 TCSYLVIO_004423 ↔ TCSYLVIO_004515	OG6
LTRL590_360040500 ATP synthase, putative	—	OG6 Tb927.10.3210 ↔ Tb927.11.9420 OG7 Tb927.10.3210 ↔ Tb927.11.9420	Both
LTRL590_310043600 ⚠ acetyl-CoA carboxylase, putative	—	OG6 Tb927.10.3210 ↔ Tb927.8.7100 OG7 Tb927.10.3210 ↔ Tb927.8.7100	Both
LTRL590_340042200 vacuolar ATP synthase catalytic subunit A, pu	—	OG6 Tb927.10.3210 ↔ Tb927.4.1080 OG7 Tb927.10.3210 ↔ Tb927.4.1080	Both
LTRL590_210021400 ATP synthase, putative	—	OG6 Tb927.10.3210 ↔ Tb927.10.730 OG7 Tb927.10.3210 ↔ Tb927.10.730	Both
LTRL590_080010500 ⚠ ribose-phosphate pyrophosphokinase, putative	—	OG6 Tb927.10.3210 ↔ Tb927.5.3170 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 OG7 Tb927.10.3210 ↔ Tb927.11.3030 +1 more	Both
LTRL590_110017400 pyruvate phosphate dikinase, putative	—	OG6 Tb927.10.3210 ↔ Tb927.11.6280 OG7 Tb927.10.3210 ↔ Tb927.11.6280	Both
LTRL590_280031900 vacuolar ATP synthase subunit b, putative	—	OG6 Tb927.10.3210 ↔ Tb927.11.11690 OG7 Tb927.10.3210 ↔ Tb927.11.11690	Both