LTRL590_220016400

translation initiation factor IF-2, putative

Leishmania tropica L590 OG6: OG6_100987 OG7: OG7_0005015 101 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 101 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LTRL590_240017900 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001462 ↔ TCSYLVIO_001768 OG7 TCSYLVIO_001462 ↔ TCSYLVIO_001768	Both
LTRL590_220006500 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001150 ↔ TCSYLVIO_001768 OG7 TCSYLVIO_001150 ↔ TCSYLVIO_001768	Both
LTRL590_110012300 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001678 ↔ TCSYLVIO_001768 OG7 TCSYLVIO_001678 ↔ TCSYLVIO_001768	Both
LTRL590_220008100 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001161 ↔ TCSYLVIO_001768 OG7 TCSYLVIO_001161 ↔ TCSYLVIO_001768	Both
LTRL590_240008000 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001546 ↔ TCSYLVIO_001768 OG7 TCSYLVIO_001546 ↔ TCSYLVIO_001768	Both
LTRL590_180005000 ⚠ kinetoplast polyadenylation/uridylation facto	—	OG6 TCSYLVIO_000834 ↔ TCSYLVIO_001768 OG7 TCSYLVIO_000834 ↔ TCSYLVIO_001768	Both
LTRL590_350032900 ⚠ acyl-CoA dehydrogenase, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_005872 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_005872	Both
LTRL590_340027400 ⚠ asparaginyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_003867 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_003867	Both
LTRL590_170007900 ⚠ Dihydrouridine synthase (Dus), putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_009102	Both
LTRL590_270008800 ⚠ nucleoporin, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_007387 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_007387	Both
LTRL590_350008600 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_005080 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_005080	Both
LTRL590_270031400 ⚠ TPR-repeat protein, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_003496	OG6
LTRL590_300017400 ⚠ importin alpha, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_003173 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_003173	Both
LTRL590_310039000 ⚠ calreticulin, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_002866 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_002866	Both
LTRL590_260014700 ⚠ Glucosidase II beta subunit-like/Glucosidase	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_002315 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_002315	Both
LTRL590_000028400 ⚠ calreticulin, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_002866 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_002866	Both
LTRL590_360029500 ⚠ NOL1/NOP2/sun family, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_004998 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_004998	Both
LTRL590_360068100 ⚠ isoleucyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_004705	Both
LTRL590_280009400 ⚠ DIS3-like exonuclease, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_002526 OG6 TCSYLVIO_001768 ↔ TCSYLVIO_002525 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_002526 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_002525	Both
LTRL590_300037200 ⚠ UV excision repair RAD23-like protein	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_003361 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_003361	Both
LTRL590_360032500 ⚠ dipeptidyl-peptidase 8-like serine peptidase,	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_007536 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_007536	Both
LTRL590_210014200 ⚠ methionyl-tRNA synthetase	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_007991	Both
LTRL590_350009100 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_005084 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_005084	Both
LTRL590_310044000 ⚠ Component of IIS longevity pathway SMK-1, put	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_002771 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_002771	Both
LTRL590_310043800 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_002771 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_002771	Both
LTRL590_050012700 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_001973 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_001973	Both
LTRL590_000007200 ⚠ tRNA (Uracil-5-)-methyltransferase, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_008409 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_008409	Both
LTRL590_140021300 ⚠ inositol-3-phosphate synthase	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_007453	Both
LTRL590_290028300 ⚠ UDP-glucose:Glycoprotein Glucosyltransferase,	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_004363 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_004363	Both
LTRL590_360005600 ⚠ stress-inducible protein STI1 homolog	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_003496	OG6
LTRL590_140010200 ⚠ N-terminal conserved domain of Nudc./CS domai	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_010327 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_010327	Both
LTRL590_250014900 ⚠ protein kinase, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_007401 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_007401	Both
LTRL590_200017200 ⚠ Pre-mRNA-splicing factor 38, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_007337 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_007337	Both
LTRL590_300035400 ⚠ DNA ligase I, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_003375 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_003375	Both
LTRL590_290022700 ⚠ XPC-binding domain/UBA/TS-N domain containing	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_004322 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_004322	Both
LTRL590_340008500 ⚠ deoxyhypusine synthase	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_001768 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_007258	Both
LTRL590_290005600 ⚠ tryptophanyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_010724 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_010724	Both
LTRL590_290033300 ⚠ NOL1/NOP2/sun family, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_004998 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_004998	Both
LTRL590_130015300 ⚠ leucyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_003028 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_003028	Both
LTRL590_060014200 ⚠ acyl-coenzyme a dehydrogenase, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_001861 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_001861	Both
LTRL590_350057800 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_005652 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_005652	Both
LTRL590_340026200 ⚠ Endonuclease/Exonuclease/phosphatase family,	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_003876 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_003876	Both
LTRL590_350015600 protein kinase, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_005149	OG6
LTRL590_250007300 ⚠ cleavage and polyadenylation specificity fact	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_005414	Both
LTRL590_230006100 ⚠ GDP-mannose pyrophosphorylase	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_007603	Both
LTRL590_250031800 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_010323 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_010323	Both
LTRL590_190012800 ⚠ ABC transport system ATP-binding protein, put	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_006012 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_006012	Both
LTRL590_280034900 ⚠ Uncharacterized ACR, COG1678, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_007619 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_007619	Both
LTRL590_360073200 ⚠ disgorgin, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_004663 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_004663	Both
LTRL590_300029000 ⚠ SET domain containing protein, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_003268 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_003268	Both

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