LTRL590_210014200

methionyl-tRNA synthetase

Leishmania tropica L590 OG6: OG6_101119 OG7: OG7_0003306 130 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 130 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LTRL590_300012000 histidyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003126 ↔ TCSYLVIO_007991 OG6 Tb927.10.1500 ↔ Tb927.6.2060 OG7 TCSYLVIO_003126 ↔ TCSYLVIO_007991 OG7 Tb927.10.1500 ↔ Tb927.6.2060	Both
LTRL590_130015300 leucyl-tRNA synthetase, putative	—	OG6 Tb927.10.1500 ↔ Tb927.11.3730 OG6 TCSYLVIO_003028 ↔ TCSYLVIO_007991 OG7 Tb927.10.1500 ↔ Tb927.11.3730 OG7 TCSYLVIO_003028 ↔ TCSYLVIO_007991	Both
LTRL590_220009800 ⚠ Putative tRNA binding domain containing prote	—	OG6 Tb927.10.1500 ↔ Tb927.7.2400 OG6 TCSYLVIO_001244 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_007991 OG7 Tb927.10.1500 ↔ Tb927.7.3620 +2 more	Both
LTRL590_160018300 ⚠ tyrosyl or methionyl-tRNA synthetase-like pro	—	OG6 Tb927.10.1500 ↔ Tb927.7.2400 OG6 TCSYLVIO_001244 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_007991 OG7 Tb927.10.1500 ↔ Tb927.7.3620 +2 more	Both
LTRL590_140021400 ⚠ tyrosyl-tRNA synthetase, putative	—	OG6 Tb927.10.1500 ↔ Tb927.7.3620 OG6 TCSYLVIO_007991 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_007991 OG7 Tb927.10.1500 ↔ Tb927.7.3620 +2 more	Both
LTRL590_300039000 valyl-tRNA synthetase, putative	—	OG6 Tb927.10.1500 ↔ Tb927.6.4480 OG6 TCSYLVIO_003345 ↔ TCSYLVIO_007991 OG7 Tb927.10.1500 ↔ Tb927.6.4480 OG7 TCSYLVIO_003345 ↔ TCSYLVIO_007991	Both
LTRL590_280008300 ⚠ rrp44p homologue, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007991	OG7
LTRL590_000028800 ⚠ Peptidase dimerisation domain/Peptidase famil	—	OG6 TCSYLVIO_007991 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_007991 ↔ TCSYLVIO_008414	Both
LTRL590_330034200 ⚠ aminopeptidase, putative	—	OG6 TCSYLVIO_005560 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_007991	Both
LTRL590_350008900 Thioredoxin, putative	—	OG6 TCSYLVIO_005083 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_005083 ↔ TCSYLVIO_007991	Both
LTRL590_300035400 ⚠ DNA ligase I, putative	—	OG6 TCSYLVIO_003375 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_003375 ↔ TCSYLVIO_007991	Both
LTRL590_200017200 Pre-mRNA-splicing factor 38, putative	—	OG6 TCSYLVIO_007337 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_007337 ↔ TCSYLVIO_007991	Both
LTRL590_300037200 UV excision repair RAD23-like protein	—	OG6 TCSYLVIO_003361 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_003361 ↔ TCSYLVIO_007991	Both
LTRL590_250028600 hypothetical protein, conserved	—	OG6 TCSYLVIO_006404 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_006404 ↔ TCSYLVIO_007991	Both
LTRL590_180006000 ⚠ alpha glucosidase II subunit, putative	—	OG6 TCSYLVIO_006140 ↔ TCSYLVIO_007991 OG6 TCSYLVIO_006141 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_006140 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_007991	Both
LTRL590_180005000 ⚠ kinetoplast polyadenylation/uridylation facto	—	OG6 TCSYLVIO_000834 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_000834 ↔ TCSYLVIO_007991	Both
LTRL590_350009100 hypothetical protein, conserved	—	OG6 TCSYLVIO_005084 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_005084 ↔ TCSYLVIO_007991	Both
LTRL590_290028300 UDP-glucose:Glycoprotein Glucosyltransferase,	—	OG6 TCSYLVIO_004363 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_004363 ↔ TCSYLVIO_007991	Both
LTRL590_220016400 ⚠ translation initiation factor IF-2, putative	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_007991	Both
LTRL590_360029500 ⚠ NOL1/NOP2/sun family, putative	—	OG6 TCSYLVIO_004998 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_004998 ↔ TCSYLVIO_007991	Both
LTRL590_290033300 ⚠ NOL1/NOP2/sun family, putative	—	OG6 TCSYLVIO_004998 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_004998 ↔ TCSYLVIO_007991	Both
LTRL590_050012700 hypothetical protein, conserved	—	OG6 TCSYLVIO_001973 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_001973 ↔ TCSYLVIO_007991	Both
LTRL590_360068100 isoleucyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007991	Both
LTRL590_270031400 ⚠ TPR-repeat protein, putative	—	OG6 TCSYLVIO_003496 ↔ TCSYLVIO_007991	OG6
LTRL590_360005600 ⚠ stress-inducible protein STI1 homolog	—	OG6 TCSYLVIO_003496 ↔ TCSYLVIO_007991	OG6
LTRL590_300010300 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007991	Both
LTRL590_210016500 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007991	Both
LTRL590_230006100 GDP-mannose pyrophosphorylase	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_007991	Both
LTRL590_300012900 ⚠ co-chaperone GrpE, putative	—	OG6 TCSYLVIO_003139 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_003139 ↔ TCSYLVIO_007991	Both
LTRL590_250007300 ⚠ cleavage and polyadenylation specificity fact	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_007991	Both
LTRL590_220019900 alanyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001889 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_001889 ↔ TCSYLVIO_007991	Both
LTRL590_280009400 ⚠ DIS3-like exonuclease, putative	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_007991 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007991	Both
LTRL590_190012800 ⚠ ABC transport system ATP-binding protein, put	—	OG6 TCSYLVIO_006012 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_006012 ↔ TCSYLVIO_007991	Both
LTRL590_330017400 hypothetical protein, conserved	—	OG6 TCSYLVIO_004910 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_004910 ↔ TCSYLVIO_007991	Both
LTRL590_320048000 Gar1/Naf1 RNA binding region containing prote	—	OG6 TCSYLVIO_000836 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_007991	Both
LTRL590_030014700 ⚠ inorganic pyrophosphatase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007991	Both
LTRL590_110007200 ⚠ acidocalcisomal pyrophosphatase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007991	Both
LTRL590_360010000 ⚠ dihydrouridine synthase domain protein-like p	—	OG7 TCSYLVIO_007991 ↔ TCSYLVIO_009102	OG7
LTRL590_170016400 ⚠ NOL1/NOP2/sun family, putative	—	OG7 TCSYLVIO_004998 ↔ TCSYLVIO_007991	OG7
LTRL590_180016600 ⚠ Multisite-specific tRNA:(cytosine-C(5))-methy	—	OG7 TCSYLVIO_004998 ↔ TCSYLVIO_007991	OG7
LTRL590_290013400 ⚠ heat shock protein 90, putative	—	OG7 TCSYLVIO_005578 ↔ TCSYLVIO_007991	OG7
LTRL590_210005600 ⚠ BAR domain containing protein, putative	—	OG7 TCSYLVIO_006877 ↔ TCSYLVIO_007991	OG7
LTRL590_210005500 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_006877 ↔ TCSYLVIO_007991	OG7
LTRL590_310018100 ⚠ N-acyl-L-amino acid amidohydrolase, putative	—	OG7 TCSYLVIO_007991 ↔ TCSYLVIO_008414	OG7
LTRL590_310029500 ⚠ dihydrouridine synthase (Dus), putative	—	OG7 TCSYLVIO_007991 ↔ TCSYLVIO_009102	OG7
LTRL590_230023700 ⚠ aminoacyclase, putative	—	OG7 TCSYLVIO_007991 ↔ TCSYLVIO_008414	OG7
LTRL590_240019500 ⚠ translation initiation factor IF-2, putative	—	OG7 TCSYLVIO_001768 ↔ TCSYLVIO_007991	OG7
LTRL590_300013000 ⚠ heat shock protein grpe	—	OG7 TCSYLVIO_003139 ↔ TCSYLVIO_007991	OG7
LTRL590_000019000 ⚠ dihydrouridine synthase (Dus), putative	—	OG7 TCSYLVIO_007991 ↔ TCSYLVIO_009102	OG7
LTRL590_230008600 ⚠ tryptophanyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_007991 ↔ TCSYLVIO_010724	OG7

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