LTRL590_110007200

acidocalcisomal pyrophosphatase

Leishmania tropica L590 OG6: OG6_100346 OG7: OG7_0003350 292 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 292 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LTRL590_010012700 ⚠ ubiquitin activating enzyme, putative	—	OG7 Tb927.11.7060 ↔ Tb927.5.3430 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_010542	OG7
LTRL590_210016500 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 Tb927.11.7060 ↔ Tb927.4.2310 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003867	OG7
LTRL590_300010300 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 Tb927.11.7060 ↔ Tb927.4.2310 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003867	OG7
LTRL590_350005300 ⚠ pyruvate kinase	—	OG6 Tb927.10.14140 ↔ Tb927.11.7060 OG6 TCSYLVIO_004455 ↔ TCSYLVIO_006133 OG7 Tb927.10.14140 ↔ Tb927.11.7060 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_006133	Both
LTRL590_350005200 ⚠ pyruvate kinase	—	OG6 Tb927.10.14140 ↔ Tb927.11.7060 OG6 TCSYLVIO_004455 ↔ TCSYLVIO_006133 OG7 Tb927.10.14140 ↔ Tb927.11.7060 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_006133	Both
LTRL590_340027400 ⚠ asparaginyl-tRNA synthetase, putative	—	OG6 Tb927.11.7060 ↔ Tb927.4.2310 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003867 OG7 Tb927.11.7060 ↔ Tb927.4.2310 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003867	Both
LTRL590_040009100 ⚠ cysteine peptidase, Clan CA, family C2, putat	—	OG6 Tb927.11.7060 ↔ Tb927.9.7540 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007342	OG6
LTRL590_200017700 ⚠ cysteine peptidase, Clan CA, family C2, putat	—	OG6 Tb927.11.7060 ↔ Tb927.9.7540 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007342	OG6
LTRL590_080007400 ⚠ ubiquitin-activating enzyme-like protein	—	OG6 Tb927.11.7060 ↔ Tb927.5.3430 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_010542 OG7 Tb927.11.7060 ↔ Tb927.5.3430 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_010542	Both
LTRL590_230006100 ⚠ GDP-mannose pyrophosphorylase	—	OG6 Tb927.11.7080 ↔ Tb927.8.2050 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007603 OG7 Tb927.11.7080 ↔ Tb927.8.2050 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007603	Both
LTRL590_250020500 ⚠ TAP42-like family, putative	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_006262 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_006262	Both
LTRL590_270031600 ⚠ aldo-keto reductase-like protein	—	OG7 TCSYLVIO_001508 ↔ TCSYLVIO_004455	OG7
LTRL590_350028800 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001709	OG7
LTRL590_080012800 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_000168 ↔ TCSYLVIO_004455	OG7
LTRL590_320045700 ⚠ Methyltransferase TYW3, putative	—	OG7 Tb927.11.12670 ↔ Tb927.11.7080	OG7
LTRL590_010005200 ⚠ MCAK-like kinesin, putative	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_004455	OG7
LTRL590_130021300 ⚠ MCAK-like kinesin, putative	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_004455	OG7
LTRL590_130006200 ⚠ MCAK-like kinesin, putative	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_004455	OG7
LTRL590_310007700 ⚠ mitotic centromere-associated kinesin (MCAK),	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_004455	OG7
LTRL590_330034200 ⚠ aminopeptidase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_001709	OG7
LTRL590_180008800 ⚠ ATP12 chaperone protein, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006163 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006163	Both
LTRL590_140020800 ⚠ serine hydroxymethyltransferase (SHMT-L)	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_010621 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_010621	Both
LTRL590_250019500 ⚠ NPL4 family, putative	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_005923 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_005923	Both
LTRL590_180011900 ⚠ serine/threonine kinase-like protein, putativ	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_009716 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_009716	Both
LTRL590_200007700 ⚠ deoxyhypusine synthase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004558 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004558 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007258	Both
LTRL590_350051600 ⚠ CS domain containing protein, putative	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_005716 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_005716	Both
LTRL590_330005900 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_009863 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_009863	Both
LTRL590_340023100 ⚠ pyroglutamyl-peptidase I (C15 family)	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_010957	Both
LTRL590_200008100 ⚠ developmentally regulated phosphoprotein-like	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_001709	Both
LTRL590_300039000 ⚠ valyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003345 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003345	Both
LTRL590_030010900 ⚠ quinone oxidoreductase, putative	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_004489 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_004489	Both
LTRL590_340007200 ⚠ CS domain containing protein, putative	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_005716 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_005716	Both
LTRL590_360006500 ⚠ PUB domain containing protein, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_009932 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_009932	Both
LTRL590_180015300 ⚠ UDP-glucose pyrophosphorylase	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_006226 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_006226	Both
LTRL590_220019900 ⚠ alanyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_001889 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_001889	Both
LTRL590_260007700 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-biphosp	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_002376 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_002376	Both
LTRL590_260024200 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003586 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003586	Both
LTRL590_300009200 ⚠ kinesin, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003093	OG6
LTRL590_300011300 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003118 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003118	Both
LTRL590_340043100 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003737 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003737	Both
LTRL590_300012000 ⚠ histidyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003126 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003126	Both
LTRL590_250028600 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006404 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006404	Both
LTRL590_360073200 ⚠ disgorgin, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004663 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004663	Both
LTRL590_360056000 ⚠ Protein of unknown function (DUF2870), putati	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_004765 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_004765	Both
LTRL590_350019400 ⚠ threonyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007511 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007511	Both
LTRL590_190007100 ⚠ C-terminal motor kinesin, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006065	OG6
LTRL590_360081400 ⚠ beta-adaptin, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004597 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004597	Both
LTRL590_300011800 ⚠ nitrate reductase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003124	OG6
LTRL590_180006000 ⚠ alpha glucosidase II subunit, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006141	Both
LTRL590_350052400 ⚠ Cysteine-rich motif following a subset of SET	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_005710 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_005710	Both

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