LTRL590_220020400

exosome complex exonuclease RRP45 homolog, putative

Leishmania tropica L590 OG6: OG6_100420 OG7: OG7_0002825 74 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 74 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LTRL590_140005000 ⚠ exosome complex exonuclease, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_010369 OG6 Tb927.6.670 ↔ Tb927.7.4670 OG6 Tb927.11.16600 ↔ Tb927.7.4670 OG6 LdBPK_140010.1 ↔ LdBPK_221430.1 +4 more	Both
LTRL590_020008200 ⚠ ribosomal RNA processing protein, putative	—	OG6 LdBPK_020290.1 ↔ LdBPK_221430.1 OG6 Tb927.11.16600 ↔ Tb927.2.2180 OG7 Tb927.11.16600 ↔ Tb927.2.2180 OG7 Tb927.10.7450 ↔ Tb927.6.670 +2 more	Both
LTRL590_040006400 ⚠ exosome complex exonuclease RRP40, putative	—	OG6 LdBPK_040130.1 ↔ LdBPK_221430.1 OG6 Tb927.6.670 ↔ Tb927.9.7070 OG6 Tb927.11.16600 ↔ Tb927.9.7070 OG7 Tb927.6.670 ↔ Tb927.9.7070 +2 more	Both
LTRL590_360060400 ⚠ exosome-associated protein 4, putative	—	OG7 Tb927.11.16600 ↔ Tb927.2.2180 OG7 Tb927.10.7450 ↔ Tb927.6.670 OG7 Tb927.10.7450 ↔ Tb927.11.16600 OG7 LdBPK_020290.1 ↔ LdBPK_221430.1	OG7
LTRL590_360039600 ⚠ exosome complex exonuclease RRP41, putative	—	OG6 Tb927.10.7450 ↔ Tb927.6.670 OG6 Tb927.10.7450 ↔ Tb927.11.16600 OG7 Tb927.11.16600 ↔ Tb927.2.2180 OG7 Tb927.10.7450 ↔ Tb927.6.670 +2 more	Both
LTRL590_340035700 ⚠ exosome subunit rrp6p homologue, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_003804 OG6 LdBPK_044330.1 ↔ LdBPK_221430.1 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_003804 OG7 LdBPK_044330.1 ↔ LdBPK_221430.1	Both
LTRL590_280018200 ⚠ Hsp70 protein, putative	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710 OG7 Tb927.6.670 ↔ Tb927.7.710 OG7 Tb927.11.16600 ↔ Tb927.7.710 +1 more	Both
LTRL590_110007600 ⚠ proteasome alpha 7 subunit, putative	—	OG6 TCSYLVIO_001707 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	Both
LTRL590_260017200 ⚠ heat-shock protein hsp70, putative	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710 OG7 Tb927.6.670 ↔ Tb927.7.710 OG7 Tb927.11.16600 ↔ Tb927.7.710 +1 more	Both
LTRL590_230025200 ⚠ Csl4p homologue, putative	—	OG6 Tb927.11.16600 ↔ Tb927.5.1200 OG6 Tb927.5.1200 ↔ Tb927.6.670 OG7 Tb927.11.16600 ↔ Tb927.5.1200 OG7 Tb927.5.1200 ↔ Tb927.6.670	Both
LTRL590_320043200 ⚠ exosome-associated protein 2, putative	—	OG6 Tb927.11.16600 ↔ Tb927.6.670 OG7 Tb927.11.16600 ↔ Tb927.6.670	Both
LTRL590_280035700 ⚠ heat-shock protein hsp70, putative	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710	OG6
LTRL590_280018100 ⚠ heat-shock protein hsp70, putative	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710 OG7 Tb927.6.670 ↔ Tb927.7.710 OG7 Tb927.11.16600 ↔ Tb927.7.710 +1 more	Both
LTRL590_280035400 ⚠ Hsp70 protein, putative	—	OG6 Tb927.6.670 ↔ Tb927.7.710 OG6 Tb927.11.16600 ↔ Tb927.7.710 OG7 Tb927.6.670 ↔ Tb927.7.710 OG7 Tb927.11.16600 ↔ Tb927.7.710 +1 more	Both
LTRL590_010011800 ⚠ HSP70-like protein	—	OG7 Tb927.6.670 ↔ Tb927.7.710 OG7 Tb927.11.16600 ↔ Tb927.7.710 OG7 Tb927.10.12710 ↔ Tb927.6.670	OG7
LTRL590_280006100 ⚠ proteasome beta 3 subunit, putative	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_001893	Both
LTRL590_360020700 ⚠ translation elongation factor 1-beta, putativ	—	OG6 Tb927.10.5840 ↔ Tb927.6.670 OG6 Tb927.10.5840 ↔ Tb927.11.16600 OG7 Tb927.10.5840 ↔ Tb927.6.670 OG7 Tb927.10.5840 ↔ Tb927.11.16600	Both
LTRL590_340013800 ⚠ elongation factor 1-beta	—	OG6 Tb927.10.5840 ↔ Tb927.6.670 OG6 Tb927.10.5840 ↔ Tb927.11.16600 OG7 Tb927.10.5840 ↔ Tb927.6.670 OG7 Tb927.10.5840 ↔ Tb927.11.16600	Both
LTRL590_350028100 ⚠ ATP-dependent RNA helicase-like protein	—	OG6 TCSYLVIO_001373 ↔ TCSYLVIO_001893	OG6
LTRL590_230021300 ⚠ T-complex protein 1, gamma subunit, putative	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	Both
LTRL590_320016500 ⚠ chaperonin containing t-complex protein, puta	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	Both
LTRL590_270018500 ⚠ T-complex protein 1, beta subunit, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	OG7
LTRL590_350045100 ⚠ T-complex protein 1, eta subunit, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	OG7
LTRL590_360083200 ⚠ T-complex protein 1, theta subunit, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	OG7
LTRL590_140008800 ⚠ proteasome alpha 3 subunit, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
LTRL590_360039400 ⚠ ATP-dependent RNA helicase, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004479	OG7
LTRL590_270007000 ⚠ proteasome alpha 7 subunit, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
LTRL590_360022700 ⚠ proteasome alpha 1 subunit, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
LTRL590_130021800 ⚠ chaperonin TCP20, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	OG7
LTRL590_080010500 ⚠ ribose-phosphate pyrophosphokinase, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004731	OG7
LTRL590_350054000 ⚠ Hsp70 protein, putative	—	OG7 Tb927.6.670 ↔ Tb927.7.710 OG7 Tb927.11.16600 ↔ Tb927.7.710 OG7 Tb927.10.12710 ↔ Tb927.6.670	OG7
LTRL590_190011400 ⚠ DNA-directed RNA polymerases I and III subuni	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010718	OG7
LTRL590_210027500 ⚠ proteasome subunit alpha type-5, putative	—	OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_001893	OG7
LTRL590_260009400 ⚠ Conserved hypothetical ATP binding protein, p	—	OG7 Tb927.11.16600 ↔ Tb927.3.1150 OG7 Tb927.3.1150 ↔ Tb927.6.670	OG7
LTRL590_200005000 ⚠ DNA-directed RNA polymerase polypeptide, puta	—	OG7 Tb927.11.16600 ↔ Tb927.11.630 OG7 Tb927.11.630 ↔ Tb927.6.670	OG7
LTRL590_260009500 ⚠ Conserved hypothetical ATP binding protein, p	—	OG7 Tb927.11.16600 ↔ Tb927.3.1150 OG7 Tb927.3.1150 ↔ Tb927.6.670	OG7
LTRL590_310006300 ⚠ DNA-directed RNA polymerase polypeptide, puta	—	OG7 Tb927.11.16600 ↔ Tb927.11.630 OG7 Tb927.11.630 ↔ Tb927.6.670	OG7
LTRL590_290006600 ⚠ DNA-directed RNA polymerase I-like protein	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_010718 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010718	Both
LTRL590_260013700 ⚠ heat shock 70 protein-like protein	—	OG7 Tb927.6.670 ↔ Tb927.7.710 OG7 Tb927.11.16600 ↔ Tb927.7.710 OG7 Tb927.10.12710 ↔ Tb927.6.670	OG7
LTRL590_350044900 ⚠ proteasome beta 2 subunit, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004939 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_006999	Both
LTRL590_090020100 ⚠ paraflagellar rod component, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_006797 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_006797	Both
LTRL590_210018300 ⚠ T-complex protein 1, delta subunit, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_008271 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_001893	Both
LTRL590_140018900 ⚠ 'Cold-shock' DNA-binding domain containing pr	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_010606 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010606	Both
LTRL590_010010900 ⚠ pre-mRNA processing factor 3 (PRP3)/Protein o	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_003433 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_003433	Both
LTRL590_030006100 ⚠ acetyltransferase, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_004519 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004519	Both
LTRL590_120005300 ⚠ proteasome beta-1 subunit, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_006999 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004939 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_006999	Both
LTRL590_340008700 ⚠ eukaryotic translation initiation factor 5, p	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004556	Both
LTRL590_310043600 ⚠ acetyl-CoA carboxylase, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_002772 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_002772	Both
LTRL590_080014700 ⚠ phosphoribosylpyrophosphate synthetase	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004731	Both
LTRL590_110007900 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001704 ↔ TCSYLVIO_001893 OG7 TCSYLVIO_001704 ↔ TCSYLVIO_001893	Both

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