LbrM.04.0170

exosome complex exonuclease RRP40, putative
Leishmania braziliensis MHOM/BR/75/M2904 OG6: OG6_102463 OG7: OG7_0007513 178 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 178 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LbrM.35.3240 ⚠
Ribosomal RNA processing protein 41A
— Both
LbrM.25.2130 ⚠
RNA polymerase I second largest subunit, puta
— Both
LbrM.32.3750 ⚠
exosome-associated protein 2, putative
— +2 more Both
LbrM.35.5140 ⚠
exosome-associated protein 4, putative
— OG7
LbrM.20.4090 ⚠
DNA-directed RNA polymerase III, putative
— OG7
LbrM.31.0270 ⚠
DNA-directed RNA polymerase II subunit 2, put
— OG7
LbrM.20.5570
exosome-associated protein 1, putative
— Both
LbrM.23.1670
exosome component CSL4, putative
— Both
LbrM.22.1490 ⚠
exosome complex exonuclease RRP45 homolog, pu
— +2 more Both
LbrM.14.0010
ribosomal RNA processing protein 4, putative,
— Both
LbrM.20.3990 ⚠
Phosphatidylinositol 3-kinase tor2
— OG7
LbrM.25.1090 ⚠
hypothetical protein, conserved
— Both
LbrM.03.0340
protein kinase, putative
— Both
LbrM.35.1570 ⚠
translation elongation factor 1-beta, putativ
— Both
LbrM.20.0810 ⚠
translation elongation factor 1-beta, putativ
— Both
LbrM.20.0770 ⚠
elongation factor 1-beta
— Both
LbrM.20.0750 ⚠
elongation factor 1-beta
— Both
LbrM.26.0500 ⚠
hypothetical protein, conserved
— OG7
LbrM.34.3430 ⚠
zinc finger protein, putative
— OG7
LbrM.35.5650 ⚠
phosphoribosylpyrophosphate synthetase, putat
— OG7
LbrM.28.2580 ⚠
DNA replication licensing factor MCM6, putati
— OG7
LbrM.32.1520 ⚠
RNA capping enzyme, cytoplasmic
— OG7
LbrM.18.0390 ⚠
tubulin tyrosine ligase protein, putative
— OG7
LbrM.05.0410 ⚠
structural maintenance of chromosome (SMC), p
— OG7
LbrM.08.0900 ⚠
phosphoribosylpyrophosphate synthetase
— OG7
LbrM.32.1560 ⚠
ATP-dependent DNA DEAD/DEAH box helicase, put
— OG7
LbrM.35.6620 ⚠
Phosphatidylinositol 3-kinase tor1
— OG7
LbrM.06.0510 ⚠
SpoU rRNA Methylase family, putative
— OG7
LbrM.24.2370 ⚠
cullin-like protein-like protein
— OG7
LbrM.16.1260 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LbrM.32.3180 ⚠
tubulin-tyrosine ligase-like protein
— OG7
LbrM.02.0130 ⚠
phosphatidylinositol kinase related protein,
— OG7
LbrM.11.0790 ⚠
adaptin-related protein-like protein
— OG7
LbrM.19.1260 ⚠
FYVE zinc finger, putative
— OG7
LbrM.21.1570 ⚠
RecF/RecN/SMC N terminal domain/SMC proteins
— OG7
LbrM.31.2290 ⚠
ubiquitin-fusion protein
— OG7
LbrM.31.2110 ⚠
ubiquitin-fusion protein
— OG7
LbrM.30.2230 ⚠
tubulin-tyrosine ligase-like protein
— OG7
LbrM.18.0660 ⚠
Zn-finger in Ran binding protein and others/F
— OG7
LbrM.04.0960 ⚠
adenylate kinase, putative
— OG7
LbrM.04.0550 ⚠
Nucleotidyltransferase domain containing prot
— OG7
LbrM.30.3470 ⚠
protein mkt1, putative
— OG7
LbrM.20.5280 ⚠
phosphatidylinositol 3-kinase, putative
— OG7
LbrM.23.1810 ⚠
neutral sphingomyelinase activation associate
— OG7
LbrM.14.1440 ⚠
ubiquitin/ribosomal protein S27a, putative
— OG7
LbrM.11.0080 ⚠
tubulin-tyrsoine ligase-like protein
— OG7
LbrM.26.0510 ⚠
DNA polymerase sigma-like protein
— OG7
LbrM.35.3280 ⚠
cullin-like protein
— OG7
LbrM.33.3060 ⚠
Concanavalin A-like lectin/glucanases superfa
— OG7
LbrM.31.2990 ⚠
acetoin dehydrogenase e3 component-like prote
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.