LbrM.20.3990

Phosphatidylinositol 3-kinase tor2
Leishmania braziliensis MHOM/BR/75/M2904 OG6: OG6_100794 OG7: OG7_0001934 341 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 341 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LbrM.32.3090 ⚠
CS domain/TPR repeat/Tetratricopeptide repeat
— OG7
LbrM.31.2980 ⚠
2-oxoglutarate dehydrogenase, e3 component, l
— OG7
LbrM.31.0230 ⚠
dihydrolipoamide dehydrogenase
— OG7
LbrM.31.2990 ⚠
acetoin dehydrogenase e3 component-like prote
— OG7
LbrM.35.5490 ⚠
glycosyl hydrolase, putative
— OG7
LbrM.33.1750 ⚠
hypothetical protein, conserved
— Both
LbrM.19.0060 ⚠
hypothetical protein, conserved
— OG7
LbrM.04.0830 ⚠
hypothetical protein, conserved
— OG7
LbrM.18.0920 ⚠
Periodic tryptophan protein 2 homolog, putati
— OG7
LbrM.32.1520 ⚠
RNA capping enzyme, cytoplasmic
— OG7
LbrM.04.0680 ⚠
hypothetical protein, conserved (fragment)
— OG7
LbrM.11.0060 ⚠
hypothetical protein, conserved
— OG7
LbrM.16.0650 ⚠
hypothetical protein, conserved
— OG7
LbrM.28.1620 ⚠
Cell division control protein 48, putative
— OG7
LbrM.17.1340 ⚠
hypothetical protein, conserved
— OG7
LbrM.24.2180 ⚠
hypothetical protein, conserved
— OG7
LbrM.23.1500 ⚠
DNA polymerase theta (helicase domain only),
— OG7
LbrM.02.0170 ⚠
RNA helicase, putative (fragment)
— OG7
LbrM.17.0940 ⚠
ATP-dependent RNA helicase, putative
— OG7
LbrM.13.0320 ⚠
ATP-dependent RNA helicase, putative
— OG7
LbrM.32.1560 ⚠
ATP-dependent DNA DEAD/DEAH box helicase, put
— OG7
LbrM.07.0770 ⚠
topoisomerase-related function protein-like p
— OG7
LbrM.26.0510 ⚠
DNA polymerase sigma-like protein
— OG7
LbrM.04.0550 ⚠
Nucleotidyltransferase domain containing prot
— OG7
LbrM.20.0330 ⚠
DNA-directed RNA polymerase III subunit C1, p
— OG7
LbrM.35.1910 ⚠
hypothetical protein, conserved
— OG7
LbrM.16.1400 ⚠
DNA-directed rna polymerase I largest subunit
— OG7
LbrM.23.0130 ⚠
Concanavalin A-like lectin/glucanases superfa
— OG7
LbrM.31.2950 ⚠
RNA polymerase ii largest subunit
— OG7
LbrM.33.3060 ⚠
Concanavalin A-like lectin/glucanases superfa
— OG7
LbrM.05.1110 ⚠
DNA-directed RNA polymerase I largest subunit
— OG7
LbrM.23.1810 ⚠
neutral sphingomyelinase activation associate
— OG7
LbrM.08.0480 ⚠
hypothetical protein, conserved
— OG7
LbrM.15.0760 ⚠
hypothetical protein, unknown function
— OG7
LbrM.25.1260 ⚠
PRP38 family, putative
— OG7
LbrM.32.3460 ⚠
NADH dehydrogenase subunit NI8M, putative
— OG7
LbrM.18.0520 ⚠
tubulin-specific chaperone, putative
— OG7
LbrM.17.0410 ⚠
hypothetical protein, conserved
— OG7
LbrM.22.1540 ⚠
ccr4-not transcription complex subunit
— OG7
LbrM.12.0350 ⚠
Myotubularin-related protein, putative
— OG7
LbrM.20.5730 ⚠
Myotubularin-related protein, putative
— OG7
LbrM.28.2310 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LbrM.25.1240 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LbrM.35.2620 ⚠
Cullin protein neddylation domain containing
— OG7
LbrM.35.3280 ⚠
cullin-like protein
— OG7
LbrM.16.1260 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LbrM.05.0420 ⚠
TPR repeat, putative
— OG7
LbrM.27.0890 ⚠
parallel beta-helix repeat, putative
— OG7
LbrM.28.2580 ⚠
DNA replication licensing factor MCM6, putati
— OG7
LbrM.22.1500 ⚠
hypothetical protein, conserved
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.