LmxM.04.0570

DENN (AEX-3) domain containing protein, putative
Leishmania mexicana MHOM/GT/2001/U1103 OG6: OG6_157986 OG7: OG7_0052278 106 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 106 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmxM.26.1260 ⚠
hypothetical protein, unknown function
— OG7
LmxM.34.1730
casein kinase II, putative
— OG6
LmxM.36.2850
hypothetical protein, conserved
— Both
LmxM.33.0300 ⚠
hypothetical protein, conserved
— Both
LmxM.19.1040
phenylalanyl-tRNA synthetase, putative
— Both
LmxM.21.0180
CHAT domain containing protein, putative
— Both
LmxM.15.0560
hypothetical protein, conserved
— Both
LmxM.08.0110
hypothetical protein, unknown function
— Both
LmxM.14.0460 ⚠
cystathionine beta-lyase-like protein
— Both
LmxM.17.0400
Ring finger domain containing protein, putati
— Both
LmxM.09.1180 ⚠
hypothetical protein, conserved
— Both
LmxM.08.0910
Beta-lactamase superfamily domain containing
— Both
LmxM.16.1150
hypothetical protein, conserved
— Both
LmxM.10.0690
hypothetical protein, conserved
— Both
LmxM.04.0030
cAMP-specific phosphodiesterase, putative
— Both
LmxM.04.0350
hypothetical protein
— Both
LmxM.01.0430 ⚠
Ring finger domain/Zn-finger in ubiquitin-hyd
— Both
LmxM.33.3280 ⚠
Zn-finger in ubiquitin-hydrolases and other p
— OG7
LmxM.10.0195 ⚠
hypothetical protein, conserved
— OG7
LmxM.34.2340 ⚠
ribonuclease, putative
— OG7
LmxM.33.3900 ⚠
Histidine kinase-, DNA gyrase B-, and HSP90-l
— OG7
LmxM.34.5390 ⚠
HECT E3 ligase, putative
— OG7
LmxM.36.4560 ⚠
PSP1 C-terminal conserved region, putative
— OG7
LmxM.31.1550 ⚠
PSP1 C-terminal conserved region, putative
— OG7
LmxM.31.1330 ⚠
PPPDE putative peptidase domain containing pr
— OG7
LmxM.10.0120 ⚠
PSP1 C-terminal conserved region, putative
— OG7
LmxM.07.0280 ⚠
HECT E3 ligase, putative
— OG7
LmxM.20.0280 ⚠
developmentally regulated phosphoprotein-like
— OG7
LmxM.33.4060 ⚠
ubiquitin hydrolase, putative
— OG7
LmxM.34.5000 ⚠
PSP1 C-terminal conserved region, putative
— OG7
LmxM.18.0600 ⚠
Zn-finger in Ran binding protein and others/F
— OG7
LmxM.21.0400 ⚠
Peptidase C19, ubiquitin carboxyl-terminal hy
— OG7
LmxM.11.0140 ⚠
hypothetical protein, conserved
— OG7
LmxM.29.1200 ⚠
ubiquitin hydrolase, putative
— OG7
LmxM.17.0170 ⚠
WD domain, G-beta repeat, putative
— OG7
LmxM.31.0760 ⚠
cyclin 9, putative
— OG7
LmxM.36.7000 ⚠
PSP1 C-terminal conserved region, putative
— OG7
LmxM.08_29.1120 ⚠
PSP1 C-terminal conserved region, putative
— OG7
LmxM.34.4260 ⚠
hypothetical protein, conserved
— OG7
LmxM.09.1170 ⚠
hypothetical protein, conserved
— OG7
LmxM.29.0910 ⚠
HECT E3 ligase, putative
— OG7
LmxM.19.0980 ⚠
FYVE zinc finger, putative
— OG7
LmxM.29.0460 ⚠
aspartyl-tRNA synthetase, putative
— OG7
LmxM.34.0950 ⚠
cell cycle sequence binding phosphoprotein (R
— OG7
LmxM.29.1090 ⚠
WW domain containing protein, putative
— OG7
LmxM.14.1170 ⚠
hypothetical protein, conserved
— OG7
LmxM.21.0820 ⚠
Temperature dependent protein affecting M2 ds
— OG7
LmxM.24.0620 ⚠
ubiquitin carboxyl-terminal hydrolase, putati
— OG7
LmxM.09.1310 ⚠
PPPDE putative peptidase domain containing pr
— OG7
LmxM.34.1740 ⚠
ubiquitin hydrolase, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.