TcCLB.504449.30

hypothetical protein, conserved

Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_143343 OG7: OG7_0028225 31 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 31 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcCLB.510855.40 proteasome regulatory non-ATPase subunit, put	—	OG6 TCSYLVIO_007057 ↔ TCSYLVIO_009688 OG7 TCSYLVIO_007057 ↔ TCSYLVIO_009688	Both
TcCLB.506223.80 ⚠ Metalloprotease M41 FtsH, putative	—	OG7 TCSYLVIO_004491 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_003002 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_004751 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_001254 ↔ TCSYLVIO_007057 +2 more	OG7
TcCLB.510105.210 ⚠ mitochondrial ATP-dependent zinc metallopepti	—	OG7 TCSYLVIO_004491 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_003002 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_004751 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_001254 ↔ TCSYLVIO_007057 +2 more	OG7
TcCLB.507739.20 ⚠ mitochondrial ATP-dependent zinc metallopepti	—	OG7 TCSYLVIO_004491 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_003002 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_004751 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_001254 ↔ TCSYLVIO_007057 +2 more	OG7
TcCLB.507213.10 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_004491 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_003002 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_004751 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_001254 ↔ TCSYLVIO_007057 +2 more	OG7
TcCLB.509769.70 ⚠ DNA polymerase theta (helicase domain only),	—	OG7 TCSYLVIO_007057 ↔ TCSYLVIO_008995	OG7
TcCLB.504051.20 ⚠ ATP-dependent DNA DEAD/DEAH box helicase, put	—	OG7 TCSYLVIO_007057 ↔ TCSYLVIO_008995	OG7
TcCLB.398751.10 ⚠ SPRY domain/HECT-domain (ubiquitin-transferas	—	OG6 TCSYLVIO_005364 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_005364 ↔ TCSYLVIO_007057	Both
TcCLB.511527.9 ⚠ SPRY domain/HECT-domain (ubiquitin-transferas	—	OG6 TCSYLVIO_005364 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_005364 ↔ TCSYLVIO_007057	Both
TcCLB.511365.10 hypothetical protein, conserved	—	OG6 TCSYLVIO_005994 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_005994 ↔ TCSYLVIO_007057	Both
TcCLB.504147.200 ⚠ 19S proteasome regulatory subunit, Regulatory	—	OG6 TCSYLVIO_004751 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_004491 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_003002 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_004751 ↔ TCSYLVIO_007057 +3 more	Both
TcCLB.510599.14 ⚠ acetyl-CoA carboxylase (fragment)	—	OG6 TCSYLVIO_002772 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_002772 ↔ TCSYLVIO_007057	Both
TcCLB.508369.50 ⚠ acetyl-CoA carboxylase (fragment)	—	OG6 TCSYLVIO_002772 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_002772 ↔ TCSYLVIO_007057	Both
TcCLB.510557.50 ⚠ mucin TcMUCII, putative	—	OG6 TCSYLVIO_002772 ↔ TCSYLVIO_007057	OG6
TcCLB.511047.50 ⚠ proteasome regulatory ATPase subunit 2, putat	—	OG6 TCSYLVIO_003002 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_004491 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_003002 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_004751 ↔ TCSYLVIO_007057 +3 more	Both
TcCLB.509625.10 ⚠ ATP-dependent RNA helicase, putative (fragmen	—	OG6 TCSYLVIO_007057 ↔ TCSYLVIO_008995 OG7 TCSYLVIO_007057 ↔ TCSYLVIO_008995	Both
TcCLB.507603.200 ⚠ proteasome regulatory ATPase subunit 3, putat	—	OG6 TCSYLVIO_006982 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_004491 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_003002 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_004751 ↔ TCSYLVIO_007057 +3 more	Both
TcCLB.503513.40 proteasome regulatory non-ATPase subunit 6, p	—	OG6 TCSYLVIO_000894 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_000894 ↔ TCSYLVIO_007057	Both
TcCLB.511315.9 ⚠ ATP-dependent RNA helicase, putative	—	OG6 TCSYLVIO_007057 ↔ TCSYLVIO_008995 OG7 TCSYLVIO_007057 ↔ TCSYLVIO_008995	Both
TcCLB.506179.59 ⚠ ATP-dependent RNA helicase, putative (fragmen	—	OG6 TCSYLVIO_007057 ↔ TCSYLVIO_008995 OG7 TCSYLVIO_007057 ↔ TCSYLVIO_008995	Both
TcCLB.511313.40 ⚠ ATP-dependent RNA helicase, putative	—	OG6 TCSYLVIO_007057 ↔ TCSYLVIO_008995 OG7 TCSYLVIO_007057 ↔ TCSYLVIO_008995	Both
TcCLB.506637.10 hypothetical protein, conserved	—	OG6 TCSYLVIO_007057 ↔ TCSYLVIO_010962 OG7 TCSYLVIO_007057 ↔ TCSYLVIO_010962	Both
TcCLB.510311.70 ⚠ 26S protease regulatory subunit, putative, se	—	OG6 TCSYLVIO_004491 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_004491 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_003002 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_004751 ↔ TCSYLVIO_007057 +3 more	Both
TcCLB.509073.119 proteasome regulatory non-ATP-ase subunit 7,	—	OG6 TCSYLVIO_005383 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_005383 ↔ TCSYLVIO_007057	Both
TcCLB.503697.9 proteasome regulatory non-ATPase subunit 11,	—	OG6 TCSYLVIO_004531 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_004531 ↔ TCSYLVIO_007057	Both
TcCLB.509489.29 proteasome regulatory non-ATP-ase subunit, pu	—	OG6 TCSYLVIO_004183 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_004183 ↔ TCSYLVIO_007057	Both
TcCLB.506859.20 ⚠ proteasome regulatory ATPase subunit 5, putat	—	OG6 TCSYLVIO_001259 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_004491 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_003002 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_004751 ↔ TCSYLVIO_007057 +3 more	Both
TcCLB.509649.30 19S proteasome non-atpase subunit 8	—	OG6 TCSYLVIO_006095 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_006095 ↔ TCSYLVIO_007057	Both
TcCLB.506857.90 ⚠ proteasome regulatory ATPase subunit 1, putat	—	OG6 TCSYLVIO_001254 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_004491 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_003002 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_004751 ↔ TCSYLVIO_007057 +3 more	Both
TcCLB.511577.10 U5Cwc21 small nuclear ribonucleoprotein	—	OG6 TCSYLVIO_003465 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_003465 ↔ TCSYLVIO_007057	Both
TcCLB.511365.70 proteasome regulatory non-ATP-ase subunit 9,	—	OG6 TCSYLVIO_005996 ↔ TCSYLVIO_007057 OG7 TCSYLVIO_005996 ↔ TCSYLVIO_007057	Both