TcCLB.507011.250

Putative death-receptor fusion protein (DUF2428), putative
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_146318 OG7: OG7_0006293 97 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 97 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.510755.147 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506223.40 ⚠
PSP1 C-terminal conserved region, putative
— OG7
TcCLB.511435.20 ⚠
Replication Factor C Subunit 1-related protei
— OG7
TcCLB.510737.110 ⚠
replication factor C, subunit 3, putative
— OG7
TcCLB.511589.160 ⚠
replication factor C, subunit 4, putative
— OG7
TcCLB.508647.40 ⚠
replication factor C, subunit 1, putative
— OG7
TcCLB.511741.30 ⚠
replication factor C, subunit 2, putative
— OG7
TcCLB.506517.100 ⚠
ATPase family associated with various cellula
— OG7
TcCLB.509153.40
hypothetical protein, conserved
— OG7
TcCLB.506633.80 ⚠
hypothetical protein, conserved
— OG7
TcCLB.511575.120 ⚠
JAB1/Mov34/MPN/PAD-1 ubiquitin protease, puta
— OG7
TcCLB.510757.9 ⚠
hypothetical protein, conserved (fragment)
— OG7
TcCLB.506513.150 ⚠
WD domain, G-beta repeat, putative
— OG7
TcCLB.506777.50 ⚠
cell cycle sequence binding phosphoprotein (R
— OG7
TcCLB.509965.40 ⚠
ubiquitin hydrolase, putative, cysteine pepti
— OG7
TcCLB.504125.30 ⚠
ubiquitin carboxyl-terminal hydrolase, putati
— OG7
TcCLB.510311.80
hypothetical protein, conserved
— OG7
TcCLB.509453.40 ⚠
DNA-directed RNA polymerase I subunit RPB10,
— Both
TcCLB.503821.10 ⚠
RNA-binding protein RBP10, putative, DNA-dire
— Both
TcCLB.506829.50
Ring finger domain/Zn-finger in ubiquitin-hyd
— Both
TcCLB.511531.40 ⚠
chaperonin alpha subunit, putative
— +4 more Both
TcCLB.510879.30
hypothetical protein, conserved
— Both
TcCLB.482369.10
protein phosphatase 2A regulatory subunit, pu
— Both
TcCLB.506747.30 ⚠
ubiquitin hydrolase, putative, cysteine pepti
— Both
TcCLB.506945.70 ⚠
protein mkt1, putative
— Both
TcCLB.506167.40 ⚠
proteasome subunit alpha type-1, putative
— OG7
TcCLB.504133.45 ⚠
Temperature dependent protein affecting M2 ds
— OG7
TcCLB.509007.40 ⚠
hypothetical protein, conserved
— OG7
TcCLB.507521.10
hypothetical protein, conserved
— OG7
TcCLB.508727.44
hypothetical protein, conserved
— OG7
TcCLB.503455.30
Protein of unknown function (DUF3648), putati
— OG7
TcCLB.509757.20 ⚠
leucine carboxyl methyltransferase, putative
— OG7
TcCLB.506755.190 ⚠
hypothetical protein, conserved
— OG7
TcCLB.506755.200 ⚠
hypothetical protein, conserved
— OG7
TcCLB.510761.70 ⚠
ubiquitin hydrolase, putative, cysteine pepti
— OG7
TcCLB.507395.14
hypothetical protein, conserved
— OG7
TcCLB.416883.18 ⚠
proteasome alpha 2 subunit, putative
— OG7
TcCLB.510181.90
hypothetical protein, conserved
— Both
TcCLB.509583.10 ⚠
chaperonin TCP20, putative
— +3 more OG7
TcCLB.504213.120 ⚠
proteasome alpha 3 subunit, putative
— OG7
TcCLB.511867.50 ⚠
proteasome alpha 7 subunit, putative
— OG7
TcCLB.506885.350 ⚠
proteasome alpha 1 subunit, putative
— OG7
TcCLB.503613.20 ⚠
proteasome alpha 7 subunit, putative
— OG7
TcCLB.510231.10 ⚠
eukaryotic translation initiation factor 2-al
— OG7
TcCLB.503905.50 ⚠
PSP1 C-terminal conserved region, putative
— OG7
TcCLB.508541.190 ⚠
cell cycle sequence binding phosphoprotein (R
— OG7
TcCLB.504103.90 ⚠
PSP1 C-terminal conserved region, putative
— OG7
TcCLB.506239.10 ⚠
hypothetical protein, conserved
— OG7
TcCLB.507611.270 ⚠
hypothetical protein, conserved
— OG7
TcCLB.504181.50 ⚠
T-complex protein 1, delta subunit, putative
— +4 more Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.