TcYC6_0074210

isovaleryl-coA dehydrogenase, putative
Trypanosoma cruzi Y C6 OG6: OG6_102105 OG7: OG7_0001034 45 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 45 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0079620 ⚠
endonuclease/exonuclease/phosphatase, putativ
— OG7
TcYC6_0028100 ⚠
tryparedoxin peroxidase, putative
— Both
TcYC6_0084380 ⚠
fatty acyl CoA synthetase 2, putative
— Both
TcYC6_0043280 ⚠
pyruvate phosphate dikinase, putative
— Both
TcYC6_0125930
aldehyde dehydrogenase
— Both
TcYC6_0024530 ⚠
inositol 5-phosphatase 1
— Both
TcYC6_0028050
hypothetical protein
— Both
TcYC6_0000770
glucose-6-phosphate 1-dehydrogenase
— Both
TcYC6_0115110
pyruvate kinase 2, putative
— Both
TcYC6_0060470
glucose-6-phosphate isomerase, glycosomal, pu
— Both
TcYC6_0088260 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0070640 ⚠
synaptojanin (N-terminal domain), putative
— OG7
TcYC6_0128180 ⚠
glutamine synthetase, putative
— Both
TcYC6_0081730 ⚠
putative synaptojanin
— OG7
TcYC6_0028200 ⚠
putative inositol/phosphatidylinositol phosph
— OG7
TcYC6_0126720 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG7
TcYC6_0098240 ⚠
glyceraldehyde 3-phosphate dehydrogenase, put
— OG7
TcYC6_0127290 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG7
TcYC6_0098230 ⚠
glyceraldehyde 3-phosphate dehydrogenase, put
— OG7
TcYC6_0047150 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG7
TcYC6_0029360 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— OG7
TcYC6_0098250 ⚠
glyceraldehyde 3-phosphate dehydrogenase, put
— OG7
TcYC6_0098600 ⚠
glutamyl-tRNA synthetase, putative
— OG7
TcYC6_0028450 ⚠
glutaminyl-tRNA synthetase, putative
— Both
TcYC6_0083700
transketolase, putative
— Both
TcYC6_0028110 ⚠
tryparedoxin peroxidase, putative
— Both
TcYC6_0084390 ⚠
fatty acyl CoA synthetase 2, putative
— Both
TcYC6_0028130 ⚠
tryparedoxin peroxidase, putative
— Both
TcYC6_0102650
adenylosuccinate synthetase, putative
— Both
TcYC6_0072570
succinyl-coA:3-ketoacid-coenzyme A transferas
— Both
TcYC6_0032470 ⚠
peroxidoxin
— Both
TcYC6_0098890
S-adenosylmethionine synthetase, putative
— Both
TcYC6_0032520
GDP-mannose pyrophosphorylase
— Both
TcYC6_0071270 ⚠
glyceraldehyde-3-phosphate dehydrogenase, put
— Both
TcYC6_0089910
hypothetical protein, conserved
— Both
TcYC6_0028120 ⚠
tryparedoxin peroxidase, putative
— Both
TcYC6_0090540
aldose 1-epimerase, putative
— Both
TcYC6_0050150
glucosamine-6-phosphate isomerase, putative
— Both
TcYC6_0046330 ⚠
glutamine synthetase, putative
— Both
TcYC6_0084400 ⚠
fatty acyl CoA synthetase 2, putative
— Both
TcYC6_0019220
nucleoside hydrolase
— Both
TcYC6_0084410 ⚠
fatty acyl CoA syntetase 1
— Both
TcYC6_0004020 ⚠
fatty acyl CoA synthetase, putative
— Both
TcYC6_0109070
guanine deaminase, putative
— Both
TcYC6_0043290 ⚠
pyruvate phosphate dikinase, putative
— Both
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.