C4B63_320g21

histone deacetylase 4
Trypanosoma cruzi Dm28c 2018 OG6: OG6_100220 OG7: OG7_0001154 72 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 72 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_81g46 ⚠
formin
— OG7
C4B63_16g132 ⚠
DNA polymerase theta (helicase domain only)
— OG7
C4B63_17g284 ⚠
ATP-dependent DNA DEAD/DEAH box helicase
— OG7
C4B63_186g23 ⚠
ATP-dependent DEAD/H RNA helicase(fragment)
— OG7
C4B63_81g52 ⚠
Gamma-tubulin complex component 3-like protei
— OG7
C4B63_2g63 ⚠
conserved hypothetical protein
— OG7
C4B63_2g83 ⚠
ubiquitin hydrolase
— OG7
C4B63_2g62 ⚠
conserved hypothetical protein
— OG7
C4B63_80g25 ⚠
ubiquitin hydrolase
— OG7
C4B63_39g349 ⚠
Tubulin-specific chaperone C
— OG7
C4B63_2g380 ⚠
phosphoribosylpyrophosphate synthetase
— OG7
C4B63_59g118 ⚠
phosphoribosylpyrophosphate synthetase
— OG7
C4B63_14g147 ⚠
phosphoribosylpyrophosphate synthetase
— OG7
C4B63_31g109 ⚠
ribose-phosphate pyrophosphokinase
— Both
C4B63_31g46 ⚠
structural maintenance of chromosome 3 protei
— Both
C4B63_85g41 ⚠
conserved hypothetical protein
— Both
C4B63_47g107 ⚠
ABC transporter
— Both
C4B63_206g11 ⚠
ABC transporter
— Both
C4B63_252g9 ⚠
ubiquitin carboxyl-terminal hydrolase
— OG7
C4B63_2g729 ⚠
structural maintenance of chromosome (SMC) fa
— OG7
C4B63_43g187 ⚠
structural maintenance of chromosome protein
— OG7
C4B63_14g249 ⚠
structural maintenance of chromosome 3
— OG7
C4B63_4g502 ⚠
ABC transporter
— OG7
C4B63_113g34 ⚠
ABC transporter
— OG7
C4B63_38g154 ⚠
Protein XRP2
— OG7
C4B63_259g8 ⚠
DNA polymerase theta (helicase domain only)
— OG7
C4B63_38g67 ⚠
adenylate kinase
— OG7
C4B63_16g21 ⚠
conserved hypothetical protein
— Both
C4B63_2g502 ⚠
ubiquitin carboxyl-terminal hydrolase
— OG7
C4B63_38g155 ⚠
conserved hypothetical protein
— OG7
C4B63_10g507 ⚠
DNA-directed RNA polymerases I and III subuni
— OG7
C4B63_48g169 ⚠
adenylate kinase 1
— OG7
C4B63_192g4 ⚠
adenylate kinase 1
— OG7
C4B63_2g60 ⚠
conserved hypothetical protein
— OG7
C4B63_81g51 ⚠
conserved hypothetical protein
— OG7
C4B63_2g61 ⚠
conserved hypothetical protein
— OG7
C4B63_263g3 ⚠
conserved hypothetical protein
— Both
C4B63_4g201 ⚠
Protein ILITYHIA
— Both
C4B63_60g174 ⚠
adenylate kinase
— Both
C4B63_127g51 ⚠
acetyl-CoA carboxylase
— Both
C4B63_94g56 ⚠
conserved hypothetical protein
— Both
C4B63_113g35 ⚠
mitogen activated protein kinase
— Both
C4B63_21g113 ⚠
conserved hypothetical protein
— Both
C4B63_19g131 ⚠
conserved hypothetical protein
— Both
C4B63_21g277 ⚠
conserved hypothetical protein
— Both
C4B63_8g209 ⚠
MORN repeat-containing protein 1
— OG6
C4B63_43g196 ⚠
adenylate kinase 1
— Both
C4B63_199g20 ⚠
conserved hypothetical protein
— Both
C4B63_4g478 ⚠
DNA-directed RNA polymerases I and III subuni
— Both
C4B63_42g107 ⚠
conserved hypothetical protein
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.