C4B63_4g250

Zinc finger, C3HC4 type (RING finger) containing protein
Trypanosoma cruzi Dm28c 2018 OG6: OG6_133034 OG7: OG7_0001851 61 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 61 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_2g88
ubiquitin-protein ligase
— OG6
C4B63_9g416 ⚠
ATP-dependent Clp protease subunit, heat shoc
— OG6
C4B63_48g28
protein prenyltransferase
— OG6
C4B63_11g18 ⚠
translation elongation factor EF-2
— OG6
C4B63_7g391 ⚠
ubiquitin hydrolase
— OG6
C4B63_7g229
Probable 18S rRNA (guanine-N(7))-methyltransf
— OG6
C4B63_294g17 ⚠
dihydrouridine synthase (Dus)
— OG6
C4B63_8g510
conserved hypothetical protein
— OG6
C4B63_4g1058c ⚠
sporangia induced deflagellation-inducible pr
— OG6
C4B63_6g389
D123
— OG6
C4B63_16g331 ⚠
ubiquitin-activating enzyme E1
— OG6
C4B63_11g17 ⚠
translation elongation factor EF-2
— OG6
C4B63_79g85 ⚠
nucleotide-binding protein
— OG6
C4B63_2g786 ⚠
ubiquitin-activating enzyme E1
— OG6
C4B63_7g392 ⚠
ubiquitin hydrolase
— OG6
C4B63_350g11 ⚠
dihydrouridine synthase (Dus)
— OG6
C4B63_9g471 ⚠
ATP-dependent protease binding subunit(fragme
— OG6
C4B63_313g3 ⚠
dihydrouridine synthase (Dus)(fragment)
— OG6
C4B63_160g33 ⚠
ubiquitin-activating enzyme E1
— OG6
C4B63_336g10 ⚠
dihydrouridine synthase (Dus)
— OG6
C4B63_227g70c ⚠
sjogren s syndrome nuclear autoantigen 1
— OG6
C4B63_49g131 ⚠
conserved hypothetical protein
— OG6
C4B63_330g2 ⚠
MRP protein
— OG6
C4B63_22g79
Tubulin/FtsZ family
— OG6
C4B63_42g192
N-alpha-acetyltransferase 25, NatB auxiliary
— OG6
C4B63_7g85
pre-mRNA splicing factor ATP-dependent RNA he
— OG6
C4B63_49g130 ⚠
Putative hydrolase C777.06c
— OG6
C4B63_127g35
peptidase
— OG6
C4B63_294g18 ⚠
dihydrouridine synthase (Dus)
— OG6
C4B63_34g313
casein kinase II, alpha chain
— OG6
C4B63_113g58
hydrogenase
— OG6
C4B63_9g299 ⚠
ATP-dependent Clp protease subunit, heat shoc
— OG6
C4B63_60g116 ⚠
aspartate carbamoyltransferase
— OG6
C4B63_35g155 ⚠
aspartate carbamoyltransferase
— OG6
C4B63_134g60 ⚠
aspartate carbamoyltransferase
— OG6
C4B63_128g63 ⚠
GTP-binding protein
— OG6
C4B63_128g62 ⚠
50S ribosome-binding GTPase
— OG6
C4B63_128g61 ⚠
50S ribosome-binding GTPase
— OG6
C4B63_56g83
conserved hypothetical protein
— OG6
C4B63_87g17 ⚠
pitrilysin-like metalloprotease
— OG6
C4B63_87g16 ⚠
pitrilysin-like metalloprotease
— OG6
C4B63_56g75 ⚠
Vacuolar protein sorting-associated protein V
— OG6
C4B63_243g12 ⚠
Vacuolar protein sorting-associated protein V
— OG6
C4B63_30g290
mercaptopyruvate sulfurtransferase
— OG6
C4B63_6g411
Replication factor A 51 kDa subunit
— OG6
C4B63_34g114 ⚠
ATP-dependent Clp protease subunit, heat shoc
— OG6
C4B63_31g264 ⚠
aspartate carbamoyltransferase
— OG6
C4B63_63g68 ⚠
ATP-dependent protease binding subunit(fragme
— OG6
C4B63_16g122 ⚠
Beta-lactamase superfamily domain containing
— OG6
C4B63_2g761
Peroxin 19
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.