LAEL147_000711800

EF-1 guanine nucleotide exchange domain containing protein, putative

Leishmania aethiopica L147 OG6: OG6_101695 OG7: OG7_0003992 64 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 64 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LAEL147_000166200 ⚠ Glutathione S-transferase, N-terminal domain	—	OG7 Tb927.10.5840 ↔ Tb927.11.13090 OG7 Tb927.10.5840 ↔ Tb927.11.13190 OG7 LdBPK_091020.1 ↔ LdBPK_361490.1 OG7 LdBPK_091020.1 ↔ LdBPK_340870.1 +2 more	OG7
LAEL147_000711600 ⚠ elongation factor 1-beta	—	OG6 LdBPK_340870.1 ↔ LdBPK_361490.1 OG6 Tb927.10.5840 ↔ Tb927.4.3590 OG7 Tb927.10.5840 ↔ Tb927.4.3590 OG7 LdBPK_340870.1 ↔ LdBPK_361490.1	Both
LAEL147_000822800 ⚠ translation elongation factor 1-beta, putativ	—	OG6 LdBPK_340870.1 ↔ LdBPK_361490.1 OG6 Tb927.10.5840 ↔ Tb927.4.3590 OG7 Tb927.10.5840 ↔ Tb927.4.3590 OG7 LdBPK_340870.1 ↔ LdBPK_361490.1	Both
LAEL147_000711900 ⚠ elongation factor 1-beta	—	OG6 LdBPK_340870.1 ↔ LdBPK_361490.1 OG6 Tb927.10.5840 ↔ Tb927.4.3590 OG7 Tb927.10.5840 ↔ Tb927.4.3590 OG7 LdBPK_340870.1 ↔ LdBPK_361490.1	Both
LAEL147_000682500 ⚠ elongation factor 1-gamma, putative	—	OG7 Tb927.10.5840 ↔ Tb927.11.13090 OG7 Tb927.10.5840 ↔ Tb927.11.13190 OG7 LdBPK_091020.1 ↔ LdBPK_361490.1 OG7 LdBPK_091020.1 ↔ LdBPK_340870.1 +2 more	OG7
LAEL147_000406100 ⚠ RNA polymerase I second largest subunit, puta	—	OG6 Tb927.10.5840 ↔ Tb927.11.630 OG7 Tb927.10.5840 ↔ Tb927.11.630	Both
LAEL147_000371100 ⚠ Csl4p homologue, putative	—	OG6 Tb927.10.5840 ↔ Tb927.5.1200 OG7 Tb927.10.5840 ↔ Tb927.5.1200	Both
LAEL147_000438100 ⚠ heat-shock protein hsp70, putative	—	OG6 Tb927.10.5840 ↔ Tb927.7.710 OG7 Tb927.10.5840 ↔ Tb927.7.710	Both
LAEL147_000842000 ⚠ exosome complex exonuclease RRP41, putative	—	OG6 Tb927.10.5840 ↔ Tb927.10.7450 OG7 Tb927.10.5840 ↔ Tb927.10.7450	Both
LAEL147_000434600 ⚠ heat shock 70 protein-like protein	—	OG7 Tb927.10.5840 ↔ Tb927.7.710	OG7
LAEL147_000206800 ⚠ WD40 repeats, putative	—	OG6 LdBPK_141530.1 ↔ LdBPK_361490.1 OG6 LdBPK_141530.1 ↔ LdBPK_340870.1 OG7 LdBPK_141530.1 ↔ LdBPK_361490.1 OG7 LdBPK_141530.1 ↔ LdBPK_340870.1	Both
LAEL147_000511500 ⚠ Hsp70 protein, putative	—	OG6 Tb927.10.5840 ↔ Tb927.7.710 OG7 Tb927.10.5840 ↔ Tb927.7.710	Both
LAEL147_000416900 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_251670.1 ↔ LdBPK_361490.1 OG6 LdBPK_251670.1 ↔ LdBPK_340870.1 OG7 LdBPK_251670.1 ↔ LdBPK_361490.1 OG7 LdBPK_251670.1 ↔ LdBPK_340870.1	Both
LAEL147_000180200 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_130700.1 ↔ LdBPK_361490.1 OG6 LdBPK_130700.1 ↔ LdBPK_340870.1 OG7 LdBPK_130700.1 ↔ LdBPK_361490.1 OG7 LdBPK_130700.1 ↔ LdBPK_340870.1	Both
LAEL147_000450200 ⚠ Zn-finger in Ran binding protein and others/S	—	OG6 LdBPK_262390.1 ↔ LdBPK_361490.1 OG6 LdBPK_262390.1 ↔ LdBPK_340870.1 OG7 LdBPK_262390.1 ↔ LdBPK_361490.1 OG7 LdBPK_262390.1 ↔ LdBPK_340870.1	Both
LAEL147_000349200 ⚠ exosome complex exonuclease RRP45 homolog, pu	—	OG6 Tb927.10.5840 ↔ Tb927.6.670 OG6 Tb927.10.5840 ↔ Tb927.11.16600 OG7 Tb927.10.5840 ↔ Tb927.6.670 OG7 Tb927.10.5840 ↔ Tb927.11.16600	Both
LAEL147_000659300 ⚠ exosome-associated protein 2, putative	—	OG6 Tb927.10.5840 ↔ Tb927.6.670 OG6 Tb927.10.5840 ↔ Tb927.11.16600 OG7 Tb927.10.5840 ↔ Tb927.6.670 OG7 Tb927.10.5840 ↔ Tb927.11.16600	Both
LAEL147_000053900 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_040740.1 ↔ LdBPK_361490.1 OG6 LdBPK_040740.1 ↔ LdBPK_340870.1 OG7 LdBPK_040740.1 ↔ LdBPK_361490.1 OG7 LdBPK_040740.1 ↔ LdBPK_340870.1	Both
LAEL147_000512000 ⚠ heat-shock protein hsp70, putative	—	OG6 Tb927.10.5840 ↔ Tb927.7.710	OG6
LAEL147_000292700 ⚠ DNA-directed RNA polymerase polypeptide, puta	—	OG7 Tb927.10.5840 ↔ Tb927.11.630	OG7
LAEL147_000189700 ⚠ exosome complex exonuclease, putative	—	OG6 Tb927.10.5840 ↔ Tb927.7.4670 OG7 Tb927.10.5840 ↔ Tb927.7.4670	Both
LAEL147_000031100 ⚠ ribosomal RNA processing protein, putative	—	OG7 Tb927.10.5840 ↔ Tb927.10.7450	OG7
LAEL147_000551200 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 Tb927.10.5840 ↔ Tb927.4.2310 OG7 Tb927.4.2310 ↔ Tb927.4.3590	OG7
LAEL147_000322800 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 Tb927.10.5840 ↔ Tb927.4.2310 OG7 Tb927.4.2310 ↔ Tb927.4.3590	OG7
LAEL147_000587800 ⚠ DNA-directed RNA polymerase polypeptide, puta	—	OG7 Tb927.10.5840 ↔ Tb927.11.630	OG7
LAEL147_000430400 ⚠ Conserved hypothetical ATP binding protein, p	—	OG7 Tb927.10.5840 ↔ Tb927.3.1150	OG7
LAEL147_000862700 ⚠ exosome-associated protein 4, putative	—	OG7 Tb927.10.5840 ↔ Tb927.10.7450	OG7
LAEL147_000271700 ⚠ heat shock protein 110, putative	—	OG7 Tb927.10.5840 ↔ Tb927.7.710	OG7
LAEL147_000025300 ⚠ HSP70-like protein	—	OG7 Tb927.10.5840 ↔ Tb927.7.710	OG7
LAEL147_000799400 ⚠ Hsp70 protein, putative	—	OG7 Tb927.10.5840 ↔ Tb927.7.710	OG7
LAEL147_000727700 ⚠ Guanine nucleotide exchange factor in Golgi t	—	OG7 LdBPK_342220.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_342220.1	OG7
LAEL147_000088000 ⚠ Sec7 domain containing protein, putative	—	OG7 LdBPK_342220.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_342220.1	OG7
LAEL147_000016300 ⚠ glutaminyl-tRNA synthetase, putative	—	OG7 LdBPK_303290.1 ↔ LdBPK_361490.1 OG7 LdBPK_303290.1 ↔ LdBPK_340870.1	OG7
LAEL147_000222700 ⚠ glutaminyl-tRNA synthetase, putative	—	OG7 LdBPK_303290.1 ↔ LdBPK_361490.1 OG7 LdBPK_303290.1 ↔ LdBPK_340870.1	OG7
LAEL147_000862000 ⚠ WD domain, G-beta repeat, putative	—	OG6 LdBPK_340870.1 ↔ LdBPK_365050.1 OG6 LdBPK_361490.1 ↔ LdBPK_365050.1 OG7 LdBPK_340870.1 ↔ LdBPK_365050.1 OG7 LdBPK_361490.1 ↔ LdBPK_365050.1	Both
LAEL147_000581100 ⚠ glutamyl-tRNA synthetase, putative	—	OG6 LdBPK_303290.1 ↔ LdBPK_361490.1 OG6 LdBPK_303290.1 ↔ LdBPK_340870.1 OG7 LdBPK_303290.1 ↔ LdBPK_361490.1 OG7 LdBPK_303290.1 ↔ LdBPK_340870.1	Both
LAEL147_000480100 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_272380.1 ↔ LdBPK_361490.1 OG6 LdBPK_272380.1 ↔ LdBPK_340870.1 OG7 LdBPK_272380.1 ↔ LdBPK_361490.1 OG7 LdBPK_272380.1 ↔ LdBPK_340870.1	Both
LAEL147_000774100 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_352430.1 ↔ LdBPK_361490.1 OG6 LdBPK_340870.1 ↔ LdBPK_352430.1 OG7 LdBPK_352430.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_352430.1	Both
LAEL147_000747800 ⚠ coatomer alpha subunit, putative	—	OG6 LdBPK_344140.1 ↔ LdBPK_361490.1 OG6 LdBPK_340870.1 ↔ LdBPK_344140.1 OG7 LdBPK_344140.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_344140.1	Both
LAEL147_000307600 ⚠ coatomer beta subunit, putative	—	OG6 LdBPK_201390.1 ↔ LdBPK_361490.1 OG6 LdBPK_201390.1 ↔ LdBPK_340870.1 OG7 LdBPK_201390.1 ↔ LdBPK_361490.1 OG7 LdBPK_201390.1 ↔ LdBPK_340870.1	Both
LAEL147_000510000 ⚠ coatomer gamma subunit, putative	—	OG6 LdBPK_282820.1 ↔ LdBPK_361490.1 OG6 LdBPK_282820.1 ↔ LdBPK_340870.1 OG7 LdBPK_282820.1 ↔ LdBPK_361490.1 OG7 LdBPK_282820.1 ↔ LdBPK_340870.1	Both
LAEL147_000416500 ⚠ ER-Golgi trafficking TRAPP I complex 85 kDa s	—	OG6 LdBPK_251630.1 ↔ LdBPK_361490.1 OG6 LdBPK_251630.1 ↔ LdBPK_340870.1 OG7 LdBPK_251630.1 ↔ LdBPK_361490.1 OG7 LdBPK_251630.1 ↔ LdBPK_340870.1	Both
LAEL147_000578900 ⚠ eukaryotic translation initiation factor 3 su	—	OG6 LdBPK_303080.1 ↔ LdBPK_361490.1 OG6 LdBPK_303080.1 ↔ LdBPK_340870.1 OG7 LdBPK_303080.1 ↔ LdBPK_361490.1 OG7 LdBPK_303080.1 ↔ LdBPK_340870.1	Both
LAEL147_000307700 ⚠ RNasePH-like protein	—	OG6 Tb927.1.2580 ↔ Tb927.10.5840 OG7 Tb927.1.2580 ↔ Tb927.10.5840	Both
LAEL147_000303000 ⚠ transmembrane protein, conserved	—	OG6 LdBPK_200940.1 ↔ LdBPK_361490.1 OG6 LdBPK_200940.1 ↔ LdBPK_340870.1 OG7 LdBPK_200940.1 ↔ LdBPK_361490.1 OG7 LdBPK_200940.1 ↔ LdBPK_340870.1	Both
LAEL147_000726600 ⚠ Sec7 domain containing protein, putative	—	OG6 LdBPK_342220.1 ↔ LdBPK_361490.1 OG6 LdBPK_340870.1 ↔ LdBPK_342220.1 OG7 LdBPK_342220.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_342220.1	Both
LAEL147_000883200 ⚠ methyltransferase, putative	—	OG6 Tb927.10.7940 ↔ Tb927.4.3590 OG6 Tb927.10.5840 ↔ Tb927.10.7940 OG7 Tb927.10.5840 ↔ Tb927.10.7940 OG7 Tb927.10.7940 ↔ Tb927.4.3590	Both
LAEL147_000690700 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_332380.1 ↔ LdBPK_361490.1 OG6 LdBPK_332380.1 ↔ LdBPK_340870.1 OG7 LdBPK_332380.1 ↔ LdBPK_361490.1 OG7 LdBPK_332380.1 ↔ LdBPK_340870.1	Both
LAEL147_000755400 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_340870.1 ↔ LdBPK_350610.1 OG6 LdBPK_350610.1 ↔ LdBPK_361490.1 OG7 LdBPK_350610.1 ↔ LdBPK_361490.1 OG7 LdBPK_340870.1 ↔ LdBPK_350610.1	Both
LAEL147_000190100 ⚠ exosome complex exonuclease, putative	—	OG6 Tb927.10.5840 ↔ Tb927.7.4670 OG7 Tb927.10.5840 ↔ Tb927.7.4670	Both

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