LAMA_000352300

Protein of unknown function (DUF2870), putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_104560 OG7: OG7_0009458 159 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 159 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000553600 ⚠
Aldo/keto reductase family, putative
— OG7
LAMA_000077700 ⚠
XRN 5'-3' exonuclease N-terminus/Xrn1 helical
— Both
LAMA_000324400 ⚠
XRN 5'-3' exonuclease N-terminus/Xrn1 helical
— Both
LAMA_000678800
hypothetical protein, conserved
— Both
LAMA_000374200
Metalloenzyme superfamily/BPG-independent PGA
— Both
LAMA_000249200
Transaldolase/Fructose-6-phosphate aldolase,
— Both
LAMA_000566800 ⚠
haloacid dehalogenase-like hydrolase/Sucrose-
— Both
LAMA_000611100
RNA recognition motif. (a.k.a. RRM, RBD, or R
— OG6
LAMA_000457300 ⚠
Aminotransferase class I and II, putative
— Both
LAMA_000775400 ⚠
Aminotransferase class I and II, putative
— Both
LAMA_000114700 ⚠
Choline/Carnitine o-acyltransferase, putative
— Both
LAMA_000663300
Alpha/beta hydrolase family/Serine aminopepti
— Both
LAMA_000552500 ⚠
50S ribosome-binding GTPase/Protein of unknow
— Both
LAMA_000665300
Importin-beta N-terminal domain/Exportin 1-li
— Both
LAMA_000761200
Phosphoglucomutase/phosphomannomutase, alpha/
— Both
LAMA_000566200
WD domain, G-beta repeat, putative
— Both
LAMA_000675300 ⚠
Cytidylyltransferase-like, putative
— Both
LAMA_000275700 ⚠
Dephospho-CoA kinase, putative
— Both
LAMA_000589700
Protein phosphatase 2C, putative
— OG6
LAMA_000453000
Alanine racemase, N-terminal domain containin
— Both
LAMA_000566500
Electron transfer flavoprotein domain/Electro
— Both
LAMA_000420700
SEP domain containing protein, putative
— Both
LAMA_000575600
Telomere recombination/Putative GTP-binding c
— Both
LAMA_000241800
Phytanoyl-CoA dioxygenase (PhyH)/2OG-Fe(II) o
— Both
LAMA_000368700
Sucrase/ferredoxin-like, putative
— Both
LAMA_000005900
Cyclophilin type peptidyl-prolyl cis-trans is
— OG6
LAMA_000624300
Ubiquitin family/Ubiquitin carboxyl-terminal
— Both
LAMA_000734700
Soluble NSF attachment protein, SNAP, putativ
— Both
LAMA_000555200
hypothetical protein, conserved
— Both
LAMA_000724400 ⚠
Transcription factor S-II (TFIIS), putative
— Both
LAMA_000084900
DeoC/LacD family aldolase, putative
— Both
LAMA_000172400 ⚠
Inorganic pyrophosphatase, putative
— Both
LAMA_000049500 ⚠
Inorganic pyrophosphatase, putative
— Both
LAMA_000194900 ⚠
Kinesin motor domain/Microtubule binding/TRAF
— OG7
LAMA_000209000 ⚠
Kinesin motor domain/Microtubule binding, put
— OG7
LAMA_000026100 ⚠
Kinesin motor domain/Microtubule binding, put
— OG7
LAMA_000626000 ⚠
Microtubule binding/Kinesin motor domain cont
— OG7
LAMA_000136400
hypothetical protein, conserved
— OG7
LAMA_000686600 ⚠
Serine hydrolase (FSH1)/50S ribosome-binding
— OG7
LAMA_000547000 ⚠
50S ribosome-binding GTPase/Ferrous iron tran
— OG7
LAMA_000079800 ⚠
U-box domain containing protein, putative
— OG7
LAMA_000574900 ⚠
Protein kinase domain/Protein tyrosine kinase
— OG7
LAMA_000801700 ⚠
FYVE zinc finger containing protein, putative
— OG7
LAMA_000298800 ⚠
FYVE zinc finger containing protein, putative
— OG7
LAMA_000590600 ⚠
Eukaryotic initiation factor 4E, putative
— OG7
LAMA_000416400 ⚠
hypothetical protein, conserved
— OG7
LAMA_000713100 ⚠
Protein tyrosine kinase/Protein kinase domain
— OG7
LAMA_000580200 ⚠
Eukaryotic initiation factor 4E, putative
— OG7
LAMA_000514200 ⚠
hypothetical protein, conserved
— OG7
LAMA_000809200 ⚠
FYVE zinc finger containing protein, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.