LPAL13_200042700

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative
Leishmania panamensis MHOM/COL/81/L13 OG6: OG6_146732 OG7: OG7_0002830 153 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 153 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LPAL13_000018300 ⚠
phenylalanyl-tRNA synthetase, putative
— OG7
LPAL13_120007400 ⚠
cysteinyl-tRNA synthetase, putative
— OG7
LPAL13_240027300 ⚠
tubulin folding cofactor D, putative
— OG7
LPAL13_240005000 ⚠
pyruvate dehydrogenase (lipoamide) kinase, pu
— OG7
LPAL13_200051800 ⚠
developmentally regulated phosphoprotein-like
— OG7
LPAL13_350074100 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
LPAL13_340028000 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
LPAL13_230012400 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
LPAL13_290026000 ⚠
aspartyl aminopeptidase, putative
— OG7
LPAL13_300010100 ⚠
aspartyl-tRNA synthetase, putative
— OG7
LPAL13_200025600 ⚠
asparaginyl-tRNA synthetase, putative
— OG7
LPAL13_210014900 ⚠
aspartyl-tRNA synthetase, putative
— OG7
LPAL13_230008300 ⚠
pteridine reductase 1
— OG7
LPAL13_340016100 ⚠
NADH-dependent fumarate reductase, putative
— OG7
LPAL13_340013100 ⚠
NADH-dependent fumarate reductase, putative
— OG7
LPAL13_070014100 ⚠
FAD binding domain containing protein, putati
— OG7
LPAL13_340016000 ⚠
NADH-dependent fumarate reductase, putative
— OG7
LPAL13_340016200 ⚠
NADH-dependent fumarate reductase, putative
— OG7
LPAL13_060014000 ⚠
lipin, putative
— OG7
LPAL13_290005200 ⚠
transcription factor-like protein
— OG7
LPAL13_180016300 ⚠
heat shock protein 110, putative
— OG7
LPAL13_350062600 ⚠
adaptin, putative
— OG7
LPAL13_000023800 ⚠
arginine N-methyltransferase, putative
— OG7
LPAL13_000047000 ⚠
hypothetical protein, conserved
— OG7
LPAL13_190016300 ⚠
peptidyl-prolyl cis-trans isomerase, macropha
— OG7
LPAL13_240014000 ⚠
inositol polyphosphate phosphatase, putative
— OG7
LPAL13_070008300 ⚠
hypothetical protein, conserved
— OG7
LPAL13_080007000 ⚠
ubiquitin-activating enzyme-like protein
— OG7
LPAL13_200021900 ⚠
Zeta toxin, putative
— OG7
LPAL13_330008200 ⚠
heat shock protein 83-17
— +2 more OG7
LPAL13_230006000 ⚠
GDP-mannose pyrophosphorylase
— OG7
LPAL13_150016700 ⚠
inositol/phosphatidylinositol phosphatase, pu
— OG7
LPAL13_310030400 ⚠
uridine kinase-like protein
— OG7
LPAL13_340053700 ⚠
Hsp70 protein, putative
— OG7
LPAL13_350017400 ⚠
endonuclease/exonuclease/phosphatase, putativ
— OG7
LPAL13_280036000 ⚠
heat-shock protein hsp70, putative
— OG7
LPAL13_110013800 ⚠
adaptin-related protein-like protein
— OG7
LPAL13_050006800 ⚠
dihydrolipoamide branched chain transacylase,
— OG7
LPAL13_120014500 ⚠
arginine N-methyltransferase-like protein
— OG7
LPAL13_290017000 ⚠
Hsp70 protein/TPR repeat, putative
— OG7
LPAL13_260017100 ⚠
heat-shock protein hsp70, putative
— OG7
LPAL13_350012900 ⚠
Protein C21orf2 homolog, putative
— OG7
LPAL13_260023300 ⚠
hypothetical protein, conserved
— OG7
LPAL13_190021400 ⚠
FK506-binding protein (FKBP)-type peptidyl-pr
— OG7
LPAL13_100014600 ⚠
FKBP-type peptidyl-prolyl cis-trans isomerase
— OG7
LPAL13_080009200 ⚠
WD domain, G-beta repeat, putative
— OG7
LPAL13_030006000 ⚠
Leucine Rich Repeat, putative
— OG7
LPAL13_280035900 ⚠
heat-shock protein hsp70, putative
— OG7
LPAL13_200015000 ⚠
uracil phosphoribosyltransferase, putative
— OG7
LPAL13_340018800 ⚠
threonyl-tRNA synthetase, putative
— OG7
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.