LPAL13_200042700

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative

Leishmania panamensis MHOM/COL/81/L13 OG6: OG6_146732 OG7: OG7_0002830 153 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 153 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LPAL13_000018300 ⚠ phenylalanyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_005548 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_240010.1	OG7
LPAL13_120007400 ⚠ cysteinyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_240010.1	OG7
LPAL13_240027300 ⚠ tubulin folding cofactor D, putative	—	OG7 LdBPK_240010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_007262	OG7
LPAL13_240005000 ⚠ pyruvate dehydrogenase (lipoamide) kinase, pu	—	OG7 Tb927.1.1000 ↔ Tb927.11.4780 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007262	OG7
LPAL13_200051800 ⚠ developmentally regulated phosphoprotein-like	—	OG7 Tb927.1.1000 ↔ Tb927.11.4780 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007262	OG7
LPAL13_350074100 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
LPAL13_340028000 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
LPAL13_230012400 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
LPAL13_290026000 ⚠ aspartyl aminopeptidase, putative	—	OG7 LdBPK_240010.1 ↔ LdBPK_292470.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004406	OG7
LPAL13_300010100 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
LPAL13_200025600 ⚠ asparaginyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
LPAL13_210014900 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
LPAL13_230008300 ⚠ pteridine reductase 1	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008848 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008848	OG7
LPAL13_340016100 ⚠ NADH-dependent fumarate reductase, putative	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
LPAL13_340013100 ⚠ NADH-dependent fumarate reductase, putative	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
LPAL13_070014100 ⚠ FAD binding domain containing protein, putati	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
LPAL13_340016000 ⚠ NADH-dependent fumarate reductase, putative	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
LPAL13_340016200 ⚠ NADH-dependent fumarate reductase, putative	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
LPAL13_060014000 ⚠ lipin, putative	—	OG7 TCSYLVIO_001856 ↔ TCSYLVIO_007262	OG7
LPAL13_290005200 ⚠ transcription factor-like protein	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010728 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010728	OG7
LPAL13_180016300 ⚠ heat shock protein 110, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005689	OG7
LPAL13_350062600 ⚠ adaptin, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004597 OG7 TCSYLVIO_004597 ↔ TCSYLVIO_007262	OG7
LPAL13_000023800 ⚠ arginine N-methyltransferase, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006901	OG7
LPAL13_000047000 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006116	OG7
LPAL13_190016300 ⚠ peptidyl-prolyl cis-trans isomerase, macropha	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005957	OG7
LPAL13_240014000 ⚠ inositol polyphosphate phosphatase, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007569	OG7
LPAL13_070008300 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006116	OG7
LPAL13_080007000 ⚠ ubiquitin-activating enzyme-like protein	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010542 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010542	OG7
LPAL13_200021900 ⚠ Zeta toxin, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010958 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010958	OG7
LPAL13_330008200 ⚠ heat shock protein 83-17	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009400 +2 more	OG7
LPAL13_230006000 ⚠ GDP-mannose pyrophosphorylase	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007603	OG7
LPAL13_150016700 ⚠ inositol/phosphatidylinositol phosphatase, pu	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007569	OG7
LPAL13_310030400 ⚠ uridine kinase-like protein	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003952	OG7
LPAL13_340053700 ⚠ Hsp70 protein, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005689	OG7
LPAL13_350017400 ⚠ endonuclease/exonuclease/phosphatase, putativ	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007569	OG7
LPAL13_280036000 ⚠ heat-shock protein hsp70, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005689	OG7
LPAL13_110013800 ⚠ adaptin-related protein-like protein	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004597 OG7 TCSYLVIO_004597 ↔ TCSYLVIO_007262	OG7
LPAL13_050006800 ⚠ dihydrolipoamide branched chain transacylase,	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009880 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009880	OG7
LPAL13_120014500 ⚠ arginine N-methyltransferase-like protein	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006901	OG7
LPAL13_290017000 ⚠ Hsp70 protein/TPR repeat, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005957	OG7
LPAL13_260017100 ⚠ heat-shock protein hsp70, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005689	OG7
LPAL13_350012900 ⚠ Protein C21orf2 homolog, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006116	OG7
LPAL13_260023300 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003586 OG7 TCSYLVIO_003586 ↔ TCSYLVIO_007262	OG7
LPAL13_190021400 ⚠ FK506-binding protein (FKBP)-type peptidyl-pr	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005957	OG7
LPAL13_100014600 ⚠ FKBP-type peptidyl-prolyl cis-trans isomerase	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005957	OG7
LPAL13_080009200 ⚠ WD domain, G-beta repeat, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010560	OG7
LPAL13_030006000 ⚠ Leucine Rich Repeat, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006116	OG7
LPAL13_280035900 ⚠ heat-shock protein hsp70, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005689	OG7
LPAL13_200015000 ⚠ uracil phosphoribosyltransferase, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003952	OG7
LPAL13_340018800 ⚠ threonyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007511 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007511	OG7

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