LPAL13_230006000

GDP-mannose pyrophosphorylase

Leishmania panamensis MHOM/COL/81/L13 OG6: OG6_100460 OG7: OG7_0001668 186 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 186 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LPAL13_060009100 glutamine synthetase, putative	—	OG6 Tb927.7.4970 ↔ Tb927.8.2050 OG6 TCSYLVIO_001811 ↔ TCSYLVIO_007603 OG7 Tb927.7.4970 ↔ Tb927.8.2050 OG7 TCSYLVIO_001811 ↔ TCSYLVIO_007603	Both
LPAL13_140019200 inositol-3-phosphate synthase	—	OG6 TCSYLVIO_007453 ↔ TCSYLVIO_007603 OG6 Tb927.10.7110 ↔ Tb927.8.2050 OG7 Tb927.10.7110 ↔ Tb927.8.2050 OG7 TCSYLVIO_007453 ↔ TCSYLVIO_007603	Both
LPAL13_030013300 ⚠ inorganic pyrophosphatase, putative	—	OG6 Tb927.11.7080 ↔ Tb927.8.2050 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007603 OG7 Tb927.11.7080 ↔ Tb927.8.2050 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007603	Both
LPAL13_190005800 ⚠ acidocalcisomal pyrophosphatase	—	OG6 Tb927.11.7080 ↔ Tb927.8.2050 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007603 OG7 Tb927.11.7080 ↔ Tb927.8.2050 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007603	Both
LPAL13_200051800 ⚠ developmentally regulated phosphoprotein-like	—	OG6 TCSYLVIO_007262 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007603	Both
LPAL13_110013800 ⚠ adaptin-related protein-like protein	—	OG7 TCSYLVIO_004597 ↔ TCSYLVIO_007603	OG7
LPAL13_050012700 hypothetical protein, conserved	—	OG6 TCSYLVIO_001973 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_001973 ↔ TCSYLVIO_007603	Both
LPAL13_280009900 ⚠ DIS3-like exonuclease, putative	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_007603 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007603	Both
LPAL13_350066100 isoleucyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007603	Both
LPAL13_350074100 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007603	Both
LPAL13_230012400 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007603	Both
LPAL13_320048400 Gar1/Naf1 RNA binding region containing prote	—	OG6 TCSYLVIO_000836 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_007603	Both
LPAL13_260023300 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_003586 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_003586 ↔ TCSYLVIO_007603	Both
LPAL13_100018300 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_003586 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_003586 ↔ TCSYLVIO_007603	Both
LPAL13_290005200 transcription factor-like protein	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010728 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010728	Both
LPAL13_200065400 tRNA (Uracil-5-)-methyltransferase, putative	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_008409 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_008409	Both
LPAL13_280031500 ⚠ serine hydroxymethyltransferase (SHMT-L)	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010621 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010621	Both
LPAL13_170008400 ⚠ Dihydrouridine synthase (Dus), putative	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_009102	Both
LPAL13_080007000 ⚠ ubiquitin-activating enzyme-like protein	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010542 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010542	Both
LPAL13_200021900 Zeta toxin, putative	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010958 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010958	Both
LPAL13_090012900 ubiquitin ligase, putative	—	OG6 TCSYLVIO_006542 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_006542 ↔ TCSYLVIO_007603	Both
LPAL13_000050400 methionyl-tRNA synthetase	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_007991	Both
LPAL13_330008200 ⚠ heat shock protein 83-17	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_008621 OG6 TCSYLVIO_007603 ↔ TCSYLVIO_009400 OG6 TCSYLVIO_007603 ↔ TCSYLVIO_009151 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_008621 +2 more	Both
LPAL13_140009600 ⚠ N-terminal conserved domain of Nudc./CS domai	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010327 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010327	Both
LPAL13_290005600 ⚠ tryptophanyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010724 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010724	Both
LPAL13_050006800 dihydrolipoamide branched chain transacylase,	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_009880 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_009880	Both
LPAL13_140019600 ⚠ tyrosyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010624	Both
LPAL13_230008300 pteridine reductase 1	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_008848 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_008848	Both
LPAL13_100007900 Exonuclease, putative	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010944	Both
LPAL13_210024700 ATP synthase F1 subunit gamma protein, putati	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_009375 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_009375	Both
LPAL13_350039200 hypothetical protein, conserved	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_009198 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_009198	Both
LPAL13_290011700 ⚠ heat shock protein 90, putative	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_008621 OG6 TCSYLVIO_007603 ↔ TCSYLVIO_009400 OG6 TCSYLVIO_007603 ↔ TCSYLVIO_009151 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_008621 +2 more	Both
LPAL13_350006200 PUB domain containing protein, putative	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_009932 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_009932	Both
LPAL13_140018600 ⚠ serine hydroxymethyltransferase (SHMT-L)	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010621 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010621	Both
LPAL13_080009200 WD domain, G-beta repeat, putative	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010560	Both
LPAL13_000033900 ⚠ mitochondrial DNA polymerase beta	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010588 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010588	Both
LPAL13_250027500 hypothetical protein, conserved	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010323 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010323	Both
LPAL13_250026100 Leucine Rich repeats (2 copies), putative	—	OG6 TCSYLVIO_006421 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_006421 ↔ TCSYLVIO_007603	Both
LPAL13_340011800 vacuolar ATP synthase subunit d, putative	—	OG6 TCSYLVIO_005104 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_005104 ↔ TCSYLVIO_007603	Both
LPAL13_350051600 paraflagellar rod component, putative	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_007603	OG6
LPAL13_300011100 hypothetical protein, conserved	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_007603	Both
LPAL13_240027300 tubulin folding cofactor D, putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_007603	Both
LPAL13_310027900 hypothetical protein, conserved	—	OG6 TCSYLVIO_003958 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_003958 ↔ TCSYLVIO_007603	Both
LPAL13_000036300 ⚠ ABC transport system ATP-binding protein, put	—	OG6 TCSYLVIO_006012 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_006012 ↔ TCSYLVIO_007603	Both
LPAL13_280008700 ⚠ rrp44p homologue, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007603	OG7
LPAL13_040008700 ⚠ mitochondrial exoribonuclease DSS-1, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007603	OG7
LPAL13_330034700 ⚠ aminopeptidase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_007603	OG7
LPAL13_000049800 ⚠ hypothetical protein	—	OG7 TCSYLVIO_007387 ↔ TCSYLVIO_007603	OG7
LPAL13_200037300 ⚠ cleavage and polyadenylation specificity fact	—	OG7 TCSYLVIO_005414 ↔ TCSYLVIO_007603	OG7
LPAL13_200017000 ⚠ Dihydrouridine synthase (Dus), putative	—	OG7 TCSYLVIO_007603 ↔ TCSYLVIO_009102	OG7

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