LPAL13_350066100

isoleucyl-tRNA synthetase, putative

Leishmania panamensis MHOM/COL/81/L13 OG6: OG6_100811 OG7: OG7_0003029 196 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 196 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LPAL13_300019400 ⚠ Peptidase family M20/M25/M40, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	Both
LPAL13_110010200 ⚠ aminopeptidase, putative	—	OG6 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
LPAL13_160015700 ⚠ tyrosyl or methionyl-tRNA synthetase-like pro	—	OG6 Tb927.10.9190 ↔ Tb927.8.5330 OG6 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010624 +1 more	Both
LPAL13_300019500 ⚠ hypothetical protein	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	Both
LPAL13_130014400 leucyl-tRNA synthetase, putative	—	OG6 Tb927.10.9190 ↔ Tb927.11.3730 OG6 TCSYLVIO_003028 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.11.3730 OG7 TCSYLVIO_003028 ↔ TCSYLVIO_004705	Both
LPAL13_300019600 ⚠ hypothetical protein	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	Both
LPAL13_220009500 ⚠ Putative tRNA binding domain containing prote	—	OG6 Tb927.10.9190 ↔ Tb927.8.5330 OG6 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010624 +1 more	Both
LPAL13_200025600 ⚠ asparaginyl-tRNA synthetase, putative	—	OG6 Tb927.10.9190 ↔ Tb927.4.2310 OG6 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 +1 more	Both
LPAL13_140019600 ⚠ tyrosyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010624 OG7 Tb927.10.9190 ↔ Tb927.8.5330	Both
LPAL13_200065900 ⚠ N-acyl-L-amino acid amidohydrolase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	Both
LPAL13_210014900 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.4.2310	Both
LPAL13_300010100 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004705 OG7 Tb927.10.9190 ↔ Tb927.4.2310	Both
LPAL13_310017200 ⚠ N-acyl-L-amino acid amidohydrolase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	Both
LPAL13_330034700 ⚠ aminopeptidase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005560 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
LPAL13_200065800 ⚠ hypothetical protein	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	Both
LPAL13_140019200 inositol-3-phosphate synthase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007453	Both
LPAL13_320028400 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_070810.1 ↔ LdBPK_365870.1	OG7
LPAL13_040008700 ⚠ mitochondrial exoribonuclease DSS-1, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_004705	OG7
LPAL13_280008700 ⚠ rrp44p homologue, putative	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_004705	OG7
LPAL13_120007700 ornithine decarboxylase, putative	—	OG6 LdBPK_120105.1 ↔ LdBPK_365870.1 OG7 LdBPK_120105.1 ↔ LdBPK_365870.1	Both
LPAL13_050010300 Translation initiation factor SUI1, putative	—	OG6 LdBPK_250420.1 ↔ LdBPK_365870.1 OG7 LdBPK_250420.1 ↔ LdBPK_365870.1	Both
LPAL13_030013300 ⚠ inorganic pyrophosphatase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004705	Both
LPAL13_190005800 ⚠ acidocalcisomal pyrophosphatase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004705	Both
LPAL13_300013000 ⚠ co-chaperone GrpE, putative	—	OG6 TCSYLVIO_003139 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_003139 ↔ TCSYLVIO_004705	Both
LPAL13_320048400 Gar1/Naf1 RNA binding region containing prote	—	OG6 TCSYLVIO_000836 ↔ TCSYLVIO_004705 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_004705	Both
LPAL13_290010000 ⚠ NF-X1 type zinc finger containing protein, pu	—	OG6 LdBPK_290620.1 ↔ LdBPK_365870.1 OG7 LdBPK_290620.1 ↔ LdBPK_365870.1	Both
LPAL13_340008900 hypothetical protein, conserved	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005084 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005084	Both
LPAL13_250027500 hypothetical protein, conserved	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_010323 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010323	Both
LPAL13_350049700 hypothetical protein, conserved	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008197 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008197	Both
LPAL13_140018600 ⚠ serine hydroxymethyltransferase (SHMT-L)	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_010621 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010621	Both
LPAL13_350006200 PUB domain containing protein, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_009932 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_009932	Both
LPAL13_250024300 hypothetical protein, conserved	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006404 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006404	Both
LPAL13_340031800 acyl-CoA dehydrogenase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005872 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005872	Both
LPAL13_340008700 Thioredoxin, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005083 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005083	Both
LPAL13_230006000 GDP-mannose pyrophosphorylase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007603	Both
LPAL13_290005600 ⚠ tryptophanyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_010724 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010724	Both
LPAL13_140009600 ⚠ N-terminal conserved domain of Nudc./CS domai	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_010327 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_010327	Both
LPAL13_200060000 Pre-mRNA-splicing factor 38, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007337 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007337	Both
LPAL13_270008900 protein kinase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005149	OG6
LPAL13_340008400 hypothetical protein, conserved	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005080 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005080	Both
LPAL13_340018900 peroxisome targeting signal 1 receptor, putat	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005361 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005361	Both
LPAL13_330032900 ⚠ heat shock protein, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005578 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005578	Both
LPAL13_000036300 ⚠ ABC transport system ATP-binding protein, put	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006012 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006012	Both
LPAL13_270020400 arginyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005509 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005509	Both
LPAL13_290027900 ⚠ NOL1/NOP2/sun family, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_004998 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_004998	Both
LPAL13_180006000 ⚠ alpha glucosidase II subunit, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006141	Both
LPAL13_210010400 la RNA binding protein, putative	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_006827 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_006827	Both
LPAL13_330016800 hypothetical protein, conserved	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_004910 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_004910	Both
LPAL13_250006900 ⚠ cleavage and polyadenylation specificity fact	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005414	Both
LPAL13_350031400 dipeptidyl-peptidase 8-like serine peptidase,	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007536 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007536	Both

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