LbrM.34.2970

ubiquitin-activating enzyme E1, putative
Leishmania braziliensis MHOM/BR/75/M2904 OG6: OG6_100444 OG7: OG7_0003530 180 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 180 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LbrM.34.1640 ⚠
ubiquitin hydrolase, putative, cysteine pepti
— OG7
LbrM.20.3690 ⚠
cysteine peptidase, Clan CA, family C19, puta
— Both
LbrM.15.1240 ⚠
cysteine peptidase, Clan CA, family C19, puta
— OG7
LbrM.35.0260 ⚠
elongation factor 2
— OG7
LbrM.30.2700 ⚠
small glutamine-rich tetratricopeptide repeat
— OG6
LbrM.23.0660 ⚠
Galactose oxidase, central domain containing
— Both
LbrM.03.0180 ⚠
hypothetical protein
— Both
LbrM.30.0180 ⚠
2-hydroxy-3-oxopropionate reductase, putative
— Both
LbrM.14.0880 ⚠
glutathione synthetase, putative
— Both
LbrM.20.4970 ⚠
tubulin-tyrosine ligase, putative
— Both
LbrM.34.2280 ⚠
Importin 1
— Both
LbrM.03.0670 ⚠
Ubiquitin-like domain containing protein, put
— Both
LbrM.34.2250 ⚠
hypothetical protein, conserved
— Both
LbrM.21.0720 ⚠
nucleotide-binding protein, putative
— Both
LbrM.28.2670 ⚠
MRP protein-like protein
— OG6
LbrM.26.0450 ⚠
nucleotide binding protein-like protein
— Both
LbrM.20.3840 ⚠
hypothetical protein, conserved
— Both
LbrM.20.4740 ⚠
hypothetical protein, conserved
— Both
LbrM.16.0320 ⚠
Met-10+ like-protein, putative
— Both
LbrM.02.0390 ⚠
casein kinase II, alpha chain, putative
— OG6
LbrM.33.0320 ⚠
ATP-binding cassette sub-family F member 1, p
— Both
LbrM.13.0600 ⚠
protein kinase, putative
— Both
LbrM.21.1180 ⚠
Programmed cell death protein 2, C-terminal p
— Both
LbrM.22.1020 ⚠
Beta-lactamase superfamily domain containing
— Both
LbrM.22.1030 ⚠
Beta-lactamase superfamily domain containing
— Both
LbrM.02.0040 ⚠
aminopeptidase P1, putative, metallo-peptidas
— Both
LbrM.25.2020 ⚠
Xaa-Pro aminopeptidase, putative
— Both
LbrM.34.0740 ⚠
proteasome activator protein pa26, putative
— Both
LbrM.03.0650 ⚠
TatD related DNase, putative
— Both
LbrM.05.0220 ⚠
hydrogenase, putative
— Both
LbrM.07.0800 ⚠
hypothetical protein, conserved
— OG7
LbrM.10.0700 ⚠
zinc-binding dehydrogenase-like protein
— OG7
LbrM.30.2220 ⚠
hypothetical protein, conserved
— OG7
LbrM.26.0760 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LbrM.22.1360 ⚠
Mitochondrial glycoprotein, putative
— OG7
LbrM.32.1190 ⚠
HECT-domain (ubiquitin-transferase), putative
— OG7
LbrM.23.0340 ⚠
hypothetical protein, conserved
— OG7
LbrM.17.0330 ⚠
dihydrouridine synthase (Dus), putative
— OG7
LbrM.35.2810 ⚠
cyclin-e binding protein 1-like protein
— OG7
LbrM.20.1170 ⚠
dihydrouridine synthase (Dus), putative
— OG7
LbrM.32.2420 ⚠
U5 small nuclear ribonucleoprotein component,
— OG7
LbrM.17.0220 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LbrM.03.0590 ⚠
DEAD/DEAH box helicase, putative
— OG7
LbrM.26.2000 ⚠
hypothetical protein, conserved
— OG7
LbrM.31.3070 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LbrM.05.0770 ⚠
Mitochondrial glycoprotein, putative
— OG7
LbrM.22.0420 ⚠
Putative tRNA binding domain containing prote
— OG7
LbrM.35.0650 ⚠
ubiquitin-like protein, putative
— OG7
LbrM.25.0910 ⚠
dehydrogenase-like protein
— OG7
LbrM.27.0800 ⚠
UBA/TS-N domain containing protein, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.