LmjF.02.0710

ATP-dependent Clp protease subunit, heat shock protein 78 (HSP78), putative
Leishmania major strain Friedlin OG6: OG6_100223 OG7: OG7_0002479 179 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 179 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.25.2080 ⚠
elongation factor 2-like protein
— Both
LmjF.30.2470 ⚠
heat shock 70-related protein 1, mitochondria
— Both
LmjF.30.2460 ⚠
heat shock 70-related protein 1, mitochondria
— Both
LmjF.36.0190 ⚠
elongation factor 2
— OG7
LmjF.36.0180 ⚠
elongation factor 2
— OG7
LmjF.30.2490 ⚠
heat shock 70-related protein 1, mitochondria
— Both
LmjF.28.2150 ⚠
hypothetical protein, conserved
— OG7
LmjF.30.2550 ⚠
heat shock 70-related protein 1, mitochondria
— Both
LmjF.36.1470 ⚠
kelch motif containing protein, putative
— OG7
LmjF.32.2200 ⚠
U5 small nuclear ribonucleoprotein component,
— Both
LmjF.24.0480 ⚠
Kelch motif/Galactose oxidase, central domain
— OG7
LmjF.20.0210 ⚠
kelch domain-containing protein
— OG7
LmjF.36.6170 ⚠
hypothetical protein, conserved
— OG7
LmjF.22.1030 ⚠
hypothetical protein, conserved
— Both
LmjF.24.2090 ⚠
Kelch motif/Galactose oxidase, central domain
— OG7
LmjF.30.2480 ⚠
heat shock 70-related protein 1, mitochondria
— Both
LmjF.28.1590 ⚠
Galactose oxidase, central domain containing
— OG7
LmjF.16.0080 ⚠
Galactose oxidase, central domain/Domain of u
— OG7
LmjF.33.0200 ⚠
metallo-peptidase, Clan MC, Family M14, putat
— OG7
LmjF.35.1740 ⚠
ubiquitin hydrolase, putative
— OG7
LmjF.36.0470 ⚠
dihydrouridine synthase domain protein-like p
— OG7
LmjF.17.0240 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LmjF.26.0740 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LmjF.34.3960 ⚠
HECT-domain (ubiquitin-transferase), putative
— OG7
LmjF.11.0620 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
LmjF.19.0800 ⚠
ABC transport system ATP-binding protein, put
— OG7
LmjF.01.0160 ⚠
LSM domain containing protein, putative
— OG7
LmjF.32.1070 ⚠
small nuclear ribonucleoprotein, putative
— OG7
LmjF.11.0630 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
LmjF.34.1140 ⚠
dihydrouridine synthase (Dus), putative
— OG7
LmjF.05.0230 ⚠
hydrogenase, putative
— Both
LmjF.24.0140 ⚠
ankyrin/TPR repeat protein
— OG6
LmjF.14.1360 ⚠
inositol-3-phosphate synthase
— Both
LmjF.23.1010 ⚠
hypothetical protein, conserved
— Both
LmjF.27.0940 ⚠
XRN 5'-3' exonuclease N-terminus, putative
— Both
LmjF.26.0430 ⚠
nucleotide binding protein-like protein
— Both
LmjF.28.2470 ⚠
MRP protein-like protein
— OG6
LmjF.21.0660 ⚠
nucleotide-binding protein, putative
— Both
LmjF.05.0260 ⚠
hypothetical protein, conserved
— Both
LmjF.02.0360 ⚠
casein kinase II, alpha chain, putative
— OG6
LmjF.28.1820 ⚠
Replication factor A protein 1
— Both
LmjF.22.1120 ⚠
Beta-lactamase superfamily domain containing
— Both
LmjF.22.1130 ⚠
Beta-lactamase superfamily domain containing
— Both
LmjF.36.4060 ⚠
regulator of chromosome condensation 1-like p
— OG7
LmjF.03.0160 ⚠
ATP-binding cassette protein subfamily F, mem
— OG7
LmjF.32.1090 ⚠
HECT-domain (ubiquitin-transferase), putative
— OG7
LmjF.05.0790 ⚠
Mitochondrial glycoprotein, putative
— OG7
LmjF.26.0750 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LmjF.36.2600 ⚠
cyclin-e binding protein 1-like protein
— OG7
LmjF.25.1705 ⚠
LSM domain containing protein, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.