LmjF.26.2370

SPRY domain/HECT-domain (ubiquitin-transferase), putative
Leishmania major strain Friedlin OG6: OG6_146743 OG7: OG7_0043053 197 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 197 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmjF.32.1130
hypothetical protein, conserved
— Both
LmjF.35.1860 ⚠
CMGC/DYRK protein kinase, putative
— OG7
LmjF.07.0050 ⚠
alpha-adaptin-like protein
— OG7
LmjF.34.3970 ⚠
AP-1 adapter complex gamma subunit, putative
— OG7
LmjF.31.2880 ⚠
aldehyde reductase, putative
— OG7
LmjF.27.2410 ⚠
aldo-keto reductase-like protein
— OG7
LmjF.08.0870
hypothetical protein, unknown function
— OG7
LmjF.13.0130 ⚠
Kinesin-13 2
— OG7
LmjF.01.0030 ⚠
Kinesin-13 1, putative
— OG7
LmjF.13.1610 ⚠
Kinesin-13 5, putative
— OG7
LmjF.31.0290 ⚠
Kinesin-13 4, putative
— OG7
LmjF.04.0740
hypothetical protein, conserved
— Both
LmjF.11.0210 ⚠
acidocalcisomal pyrophosphatase
— Both
LmjF.03.0910 ⚠
inorganic pyrophosphatase, putative
— Both
LmjF.33.1580
hypothetical protein, conserved
— Both
LmjF.33.2250
hypothetical protein, conserved
— Both
LmjF.34.1000 ⚠
myosin IB heavy chain, putative
— Both
LmjF.30.3060
kinesin, putative
— OG6
LmjF.36.1430 ⚠
translation elongation factor 1-beta, putativ
— Both
LmjF.30.3040
eukaryotic translation initiation factor 3 su
— Both
LmjF.34.0870
hypothetical protein, conserved
— Both
LmjF.36.6960
elks delta-like protein
— Both
LmjF.28.2620
Coatomer subunit gamma
— Both
LmjF.34.3460
hypothetical protein, conserved
— Both
LmjF.29.1110
hypothetical protein, conserved
— Both
LmjF.35.0610
hypothetical protein, conserved
— Both
LmjF.22.0320
SEP domain containing protein, putative
— Both
LmjF.21.1150
hypothetical protein, conserved
— Both
LmjF.24.1060
AKAP7 2'5' RNA ligase-like domain containing
— Both
LmjF.14.1430
hypothetical protein, conserved
— Both
LmjF.34.3780
phosphomannomutase-like protein
— Both
LmjF.15.0700
hypothetical protein, conserved
— Both
LmjF.31.0140
ubiquitin carboxyl-terminal hydrolase, putati
— Both
LmjF.28.2070
tRNA threonylcarbamoyl adenosine modification
— Both
LmjF.33.0960
nicotinate phosphoribosyltransferase, putativ
— Both
LmjF.33.2810 ⚠
transcription elongation factor-like protein
— Both
LmjF.01.0220
cyclophilin 12, putative
— OG6
LmjF.25.1610
Eukaryotic translation initiation factor 3 su
— Both
LmjF.27.2430
hypothetical protein, conserved
— Both
LmjF.32.2850
CS domain/TPR repeat/Tetratricopeptide repeat
— Both
LmjF.34.2450 ⚠
Sec7 domain containing protein, putative
— Both
LmjF.34.0820 ⚠
elongation factor 1-beta
— Both
LmjF.36.6980
eukaryotic translation initiation factor 3 su
— Both
LmjF.34.0840 ⚠
translation elongation factor 1-beta, putativ
— Both
LmjF.34.4310
coatomer alpha subunit, putative
— Both
LmjF.31.1000
hypothetical protein, conserved
— Both
LmjF.33.2630 ⚠
dynein intermediate chain, putative
— Both
LmjF.36.0540 ⚠
ubiquitin-like protein, putative
— OG7
LmjF.35.2380
hypothetical protein, unknown function
— Both
LmjF.36.4820
WD domain, G-beta repeat, putative
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.