LmxM.29.3500

S-adenosylmethionine synthetase
Leishmania mexicana MHOM/GT/2001/U1103 OG6: OG6_100388 OG7: OG7_0003674 40 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Network view all shared interactors, plus up to 150 more
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Interactions 40 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LmxM.12.0530
glucose-6-phosphate isomerase
— Both
LmxM.01.0500 ⚠
fatty acyl CoA synthetase 2, putative
— Both
LmxM.01.0520 ⚠
long-chain-fatty-acid-CoA ligase, putative
— Both
LmxM.17.0350 ⚠
dihydrouridine synthase (Dus), putative
— Both
LmxM.24.2060
transketolase, putative
— Both
LmxM.14.0130 ⚠
nucleoside hydrolase-like protein
— Both
LmxM.34.4750 ⚠
glyceraldehyde-3-phosphate dehydrogenase-like
— +1 more Both
LmxM.01.0490 ⚠
long-chain-fatty-acid-CoA ligase, putative
— Both
LmxM.24.0320 ⚠
fumarate hydratase, putative
— Both
LmxM.08_29.1960 ⚠
fumarate hydratase, putative
— Both
LmxM.15.1440 ⚠
glutaminyl-tRNA synthetase, putative
— Both
LmxM.34.0030 ⚠
pyruvate kinase, putative
— Both
LmxM.34.0020 ⚠
pyruvate kinase
— Both
LmxM.36.0470 ⚠
dihydrouridine synthase domain protein-like p
— OG7
LmxM.29.3240 ⚠
glutamyl-tRNA synthetase, putative
— OG7
LmxM.01.0530 ⚠
long-chain-fatty-acid-CoA ligase, putative
— OG7
LmxM.30.1930 ⚠
dihydrouridine synthase (Dus), putative
— OG7
LmxM.33.1140 ⚠
dihydrouridine synthase (Dus), putative
— OG7
LmxM.29.1800 ⚠
queuine tRNA-ribosyltransferase, putative
— OG7
LmxM.36.5180 ⚠
aldehyde dehydrogenase, putative
— OG7
LmxM.27.0930
isovaleryl-coA dehydrogenase, putative
— Both
LmxM.29.2900 ⚠
aldehyde dehydrogenase, putative
— Both
LmxM.36.2350 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— Both
LmxM.29.2980 ⚠
glyceraldehyde 3-phosphate dehydrogenase, gly
— Both
LmxM.28.1200 ⚠
luminal binding protein 1 (BiP), putative
— OG6
LmxM.28.2820 ⚠
heat shock protein 70, putative
— Both
LmxM.28.2770 ⚠
heat-shock protein hsp70, putative
— OG6
LmxM.26.1240 ⚠
heat shock protein 70-related protein
— OG6
LmxM.28.2780 ⚠
heat-shock protein hsp70, putative
— OG6
LmxM.27.0030 ⚠
queuine tRNA-ribosyltransferase, putative
— Both
LmxM.13.1190
adenylosuccinate synthetase, putative
— Both
LmxM.11.0130
NGG1 interacting factor 3-like protein
— Both
LmxM.05.0350
trypanothione reductase
— Both
LmxM.29.3130
valyl-tRNA synthetase, putative
— Both
LmxM.08_29.0867
guanine deaminase, putative
— Both
LmxM.12.0630
alanine aminotransferase, putative
— Both
LmxM.03.0230 ⚠
long chain fatty Acyl CoA synthetase, putativ
— Both
LmxM.01.0470 ⚠
fatty acyl CoA syntetase 1, putative
— Both
LmxM.18.1580 ⚠
nonspecific nucleoside hydrolase
— Both
LmxM.15.1450
proliferative cell nuclear antigen (PCNA), pu
— Both
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.