TcIL3000_4_420

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative

Trypanosoma congolense IL3000 OG6: OG6_146732 OG7: OG7_0002830 156 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 156 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcIL3000.11.2160 ⚠ phenylalanyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_005548 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_240010.1	OG7
TcIL3000_0_50370 ⚠ tubulin folding cofactor D, putative (fragmen	—	OG7 LdBPK_240010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_007262	OG7
TcIL3000_0_28240 ⚠ cysteinyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_240010.1	OG7
TcIL3000_8_6040 ⚠ tubulin folding cofactor D, putative	—	OG7 LdBPK_240010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_007262	OG7
TcIL3000_1_420 ⚠ developmentally regulated phosphoprotein, put	—	OG7 Tb927.1.1000 ↔ Tb927.11.4780 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007262	OG7
TcIL3000_0_14610 ⚠ pyruvate dehydrogenase (lipoamide) kinase, pu	—	OG7 Tb927.1.1000 ↔ Tb927.11.4780 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007262	OG7
TcIL3000_9_5730 ⚠ ribonuclease, putative	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
TcIL3000_0_41370 ⚠ Poly(A)-specific ribonuclease PARN-1	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
TcIL3000_10_7200 ⚠ ribonuclease, putative	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
TcIL3000_6_1480 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
TcIL3000_0_42510 ⚠ aspartyl aminopeptidase, putative	—	OG7 LdBPK_240010.1 ↔ LdBPK_292470.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004406	OG7
TcIL3000_4_2130 ⚠ asparaginyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
TcIL3000_10_1050 ⚠ OB-fold nucleic acid binding domain/tRNA synt	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
TcIL3000_8_4490 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003586 OG7 TCSYLVIO_003586 ↔ TCSYLVIO_007262	OG7
TcIL3000_0_44250 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001673 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_001673	OG7
TcIL3000.11.7210 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001673 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_001673	OG7
TcIL3000_9_1440 ⚠ DNA-damage inducible protein DDI1-like protei	—	OG7 TCSYLVIO_003428 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003428	OG7
TcIL3000_0_22370 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
TcIL3000_10_2980 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
TcIL3000_5_630 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
TcIL3000_5_620 ⚠ NADH-dependent fumarate reductase (fragment)	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
TcIL3000_0_22360 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
TcIL3000_5_640 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
TcIL3000_10_1880 ⚠ vacuolar protein sorting-associated protein 3	—	OG7 LdBPK_210530.1 ↔ LdBPK_240010.1	OG7
TcIL3000_8_360 ⚠ Domain of unknown function (DUF3437), putativ	—	OG7 LdBPK_071090.1 ↔ LdBPK_240010.1	OG7
TcIL3000.11.1710 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_005512 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005512	OG7
TcIL3000_0_26160 ⚠ Adaptor protein complex AP-3 subunit beta-3	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004597 OG7 TCSYLVIO_004597 ↔ TCSYLVIO_007262	OG7
TcIL3000.11.5770 ⚠ synaptojanin (N-terminal domain), putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007569	OG7
TcIL3000_8_3680 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008446 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008446	OG7
TcIL3000_10_50 ⚠ ATP synthase F1 subunit gamma protein, putati	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009375 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009375	OG7
TcIL3000_7_4530 ⚠ protein arginine n-methyltransferase 7 (fragm	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006901	OG7
TcIL3000_5_4500 ⚠ arginine N-methyltransferase, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006901	OG7
TcIL3000_10_6910 ⚠ beta adaptin, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004597 OG7 TCSYLVIO_004597 ↔ TCSYLVIO_007262	OG7
TcIL3000.11.6700 ⚠ protein transport protein SEC31, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_001623	OG7
TcIL3000_9_770 ⚠ hypothetical protein (fragment)	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003586 OG7 TCSYLVIO_003586 ↔ TCSYLVIO_007262	OG7
TcIL3000_0_30110 ⚠ WD domain, G-beta repeat, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010560	OG7
TcIL3000_5_3890 ⚠ ubiquitin-activating enzyme E1, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010542 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010542	OG7
TcIL3000_9_4170 ⚠ synaptojanin (N-terminal domain), putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007569	OG7
TcIL3000_9_1520 ⚠ ubiquitin-activating enzyme E1, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010542 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010542	OG7
TcIL3000_5_860 ⚠ threonyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007511 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007511	OG7
TcIL3000.11.9810 ⚠ hypothetical protein	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009198 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009198	OG7
TcIL3000_4_260 ⚠ GRIP domain containing protein, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003707 OG7 TCSYLVIO_003707 ↔ TCSYLVIO_007262	OG7
TcIL3000.11.8260 ⚠ oxidoreductase-like protein	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_002566	OG7
TcIL3000_9_5050 ⚠ leucine-rich repeat protein (LRRP), putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006116	OG7
TcIL3000_0_48690 ⚠ heat shock protein 90, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009400 +2 more	OG7
TcIL3000_0_14040 ⚠ leucine-rich repeat protein (LRRP), putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006116	OG7
TcIL3000_0_21000 ⚠ hypothetical protein, conserved (fragment)	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010560	OG7
TcIL3000_0_26120 ⚠ Hsp90 protein, putative (fragment)	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009400 +2 more	OG7
TcIL3000_9_760 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003586 OG7 TCSYLVIO_003586 ↔ TCSYLVIO_007262	OG7
TcIL3000.11.2400 ⚠ heat shock protein, mitochondrial precursor,	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009400 +2 more	OG7

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