TcIL3000_8_6040

tubulin folding cofactor D, putative

Trypanosoma congolense IL3000 OG6: OG6_102599 OG7: OG7_0006853 239 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 239 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcIL3000_10_7200 ⚠ ribonuclease, putative	—	OG6 LdBPK_230660.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 LdBPK_230660.1 ↔ LdBPK_242100.1	Both
TcIL3000_0_41370 ⚠ Poly(A)-specific ribonuclease PARN-1	—	OG6 LdBPK_230660.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 LdBPK_230660.1 ↔ LdBPK_242100.1	Both
TcIL3000_6_1480 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003107 OG7 LdBPK_242100.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003867 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003107	Both
TcIL3000_0_28240 ⚠ cysteinyl-tRNA synthetase, putative	—	OG6 LdBPK_120255.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_006977	Both
TcIL3000_10_1050 ⚠ OB-fold nucleic acid binding domain/tRNA synt	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003107 OG7 LdBPK_242100.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003867 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003107	Both
TcIL3000_0_13010 ⚠ WD domain, G-beta repeat, putative	—	OG6 LdBPK_080420.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_010560	Both
TcIL3000_0_21000 ⚠ hypothetical protein, conserved (fragment)	—	OG6 LdBPK_080420.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_010560	Both
TcIL3000_0_30110 ⚠ WD domain, G-beta repeat, putative	—	OG6 LdBPK_080420.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_010560	Both
TcIL3000_9_5730 ⚠ ribonuclease, putative	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 LdBPK_230660.1 ↔ LdBPK_242100.1	OG7
TcIL3000_4_2130 ⚠ asparaginyl-tRNA synthetase, putative	—	OG6 LdBPK_242100.1 ↔ LdBPK_342110.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003867 OG7 LdBPK_242100.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003867 +1 more	Both
TcIL3000.11.2160 ⚠ phenylalanyl-tRNA synthetase, putative	—	OG6 LdBPK_191010.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_005548	Both
TcIL3000_0_14610 ⚠ pyruvate dehydrogenase (lipoamide) kinase, pu	—	OG6 LdBPK_240010.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_001571 OG7 LdBPK_240010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001571 +1 more	Both
TcIL3000_6_1570 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_242100.1 ↔ LdBPK_300580.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003118 OG7 LdBPK_242100.1 ↔ LdBPK_300580.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003118	Both
TcIL3000_10_10990 ⚠ bifunctional aminoacyl-tRNA synthetase, putat	—	OG6 LdBPK_181220.1 ↔ LdBPK_242100.1 OG6 LdBPK_181230.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_242100.1 +2 more	Both
TcIL3000_4_420 ⚠ Histidine kinase-, DNA gyrase B-, and HSP90-l	—	OG7 LdBPK_240010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_007262	OG7
TcIL3000_1_420 ⚠ developmentally regulated phosphoprotein, put	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_007262	Both
TcIL3000_6_2060 ⚠ hypothetical protein, conserved (fragment)	—	OG7 LdBPK_161180.1 ↔ LdBPK_242100.1	OG7
TcIL3000_10_8740 ⚠ paraflagellar rod component, putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_004736 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_004736	Both
TcIL3000_8_1450 ⚠ ubiquitin-protein ligase, putative	—	OG7 LdBPK_161180.1 ↔ LdBPK_242100.1	OG7
TcIL3000_0_25450 ⚠ SPRY domain containing protein, putative (fra	—	OG7 LdBPK_161180.1 ↔ LdBPK_242100.1	OG7
TcIL3000_0_11960 ⚠ HECT-domain (ubiquitin-transferase), putative	—	OG7 LdBPK_161180.1 ↔ LdBPK_242100.1	OG7
TcIL3000_0_55120 ⚠ hypothetical protein	—	OG7 LdBPK_161180.1 ↔ LdBPK_242100.1	OG7
TcIL3000_6_1870 ⚠ ubiquitin-protein ligase, putative	—	OG7 LdBPK_161180.1 ↔ LdBPK_242100.1	OG7
TcIL3000_10_7240 ⚠ Concanavalin A-like lectin/glucanases superfa	—	OG7 LdBPK_161180.1 ↔ LdBPK_242100.1	OG7
TcIL3000_0_38710 ⚠ ubiquitin-protein ligase, putative	—	OG7 LdBPK_161180.1 ↔ LdBPK_242100.1	OG7
TcIL3000_10_7230 ⚠ Concanavalin A-like lectin/glucanases superfa	—	OG7 LdBPK_161180.1 ↔ LdBPK_242100.1	OG7
TcIL3000_9_5080 ⚠ replication factor C, subunit 3, putative (fr	—	OG7 LdBPK_241010.1 ↔ LdBPK_242100.1	OG7
TcIL3000_6_3350 ⚠ replication factor C, subunit 2, putative	—	OG7 LdBPK_241010.1 ↔ LdBPK_242100.1	OG7
TcIL3000_0_50610 ⚠ Replication Factor C Subunit 1-related protei	—	OG7 LdBPK_241010.1 ↔ LdBPK_242100.1	OG7
TcIL3000_10_6860 ⚠ replication factor C subunit 3, putative	—	OG7 LdBPK_241010.1 ↔ LdBPK_242100.1	OG7
TcIL3000_0_25410 ⚠ ATPase family associated with various cellula	—	OG7 LdBPK_241010.1 ↔ LdBPK_242100.1	OG7
TcIL3000_0_39040 ⚠ hypothetical protein (fragment)	—	OG7 LdBPK_241010.1 ↔ LdBPK_242100.1	OG7
TcIL3000.11.10020 ⚠ replication factor C, subunit 4, putative	—	OG7 LdBPK_241010.1 ↔ LdBPK_242100.1	OG7
TcIL3000.11.14420 ⚠ phenylalanyl-tRNA synthetase alpha chain, put	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_004213 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_004213	Both
TcIL3000_0_59390 ⚠ Ankyrin repeats (3 copies), putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_001559	OG6
TcIL3000_9_4940 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005810 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_005810	Both
TcIL3000_0_40200 ⚠ heat shock 70 kDa protein, putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_002696	OG6
TcIL3000_0_40210 ⚠ heat shock 70 kDa protein, putative (fragment	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_002696	OG6
TcIL3000_9_5290 ⚠ Leucine carboxyl methyltransferase/Cupin-like	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005852 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_005852	Both
TcIL3000_10_2480 ⚠ hypothetical protein (fragment)	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_001559	OG6
TcIL3000_9_2560 ⚠ cysteine peptidase, Clan CA, family C2, putat	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_007342	OG6
TcIL3000_0_22360 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_005116 +2 more	Both
TcIL3000.11.7210 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_001673 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001673	Both
TcIL3000_0_35850 ⚠ ubiquitin ligase, putative (fragment)	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_006542 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_006542	Both
TcIL3000_0_35010 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_001670 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001670	Both
TcIL3000_5_620 ⚠ NADH-dependent fumarate reductase (fragment)	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_005116 +2 more	Both
TcIL3000.11.9820 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_009198 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_009198	Both
TcIL3000.11.9840 ⚠ ATP synthase, putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_009199 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_009199	Both
TcIL3000_0_35600 ⚠ SPRY domain containing protein, putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_002919 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_002919	Both
TcIL3000_0_26120 ⚠ Hsp90 protein, putative (fragment)	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_008621 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_009400 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_009151 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_008621 +2 more	Both

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